Prostate sclerosing adenopathy: A clinicopathological and immunohistochemical study of twelve patients

Table 1 Clinical characteristics of patients with prostate sclerosing adenopathy

Case	Age of onset (yr)	Clinical symptoms	Difficulty urinating	PSA check value (ng/mL)	Imaging diagnosis	Surgical findings	Surgical approach	Follow up
1	76	Difficulty urinating	Without	2.43	Benign prostatic hyperplasia	The lobes on both sides of the prostate protrude and protrude into the bladder, and the urethral cavity is narrowed	Transurethral plasma resection of the prostate	Survival and good, normal rectal examination, 73 mo
2	62	Hematuria	Bladder papilloma	5.21	Bladder cancer, invasion of the prostate	Irregular hyperplasia of the right side of the bladder, invading the adjacent prostate	Total cystectomy and double-layer ureterostomy	Died from bladder cancer, 27 mo
3	63	Frequent urination, difficulty urinating	Cholecystectomy; history of hypertension	1.73	Prostate cancer	The lobes on both sides of the prostate proliferate and protrude into the bladder	Transurethral plasma resection of the prostate	Survival and good, normal rectal examination, 69 mo
4	68	Gross hematuria	History of gastrectomy	3.36	Bladder Cancer	Prostatic hyperplasia, multiple neoplastic new organisms are seen in the bladder triangle and right wall	Total cystectomy and intestinal replacement for new bladder	Alive, 46 mo
5	67	Frequent urination, urgency	Without	1.34	Benign prostatic hyperplasia	Irregular hyperplasia of the lobes on both sides of the prostate	Transurethral plasma resection of the prostate	Survival and good, normal rectal examination, 24 mo
6	83	Frequent urination, difficulty urinating	History of hypertension, diabetes	3.81	Benign prostatic hyperplasia	Irregular hyperplasia of the lobes on both sides of the prostate	Transurethral plasma resection of the prostate	Survival and good, normal rectal examination, 21 mo
7	67	High blood pressure	History of prostatitis, appendix surgery	2,76	Prostatic hyperplasia with calcification	Enlargement of the right side wall of the prostate	Transurethral plasma resection of the prostate	Survival and good, normal rectal examination, 2 mo
8	83	Hematuria with frequent urination and urgency	Right inguinal hernia repair	4.91	Prostatic hyperplasia with calcification	Significant enlargement of the bilateral and middle lobes of the prostate	Transurethral resection of the prostate	Survival and good, 3 mo
9	72	Frequent urination, urgency	History of hypertension, diabetes	2.21	Prostatic hyperplasia with calcification	The lobes on both sides of the prostate proliferate and protrude into the bladder	Transurethral resection of the prostate	Survival and good, normal rectal examination, 6 mo
10	68	Difficulty urinating	Without	2.39	Benign prostatic hyperplasia	Irregular hyperplasia of the lobes on both sides of the prostate	Transurethral resection of the prostate	Survival and good, normal rectal examination, 13 mo
11	81	Frequent urination, urgency	Bladder papilloma	3.31	Benign prostatic hyperplasia	Irregular hyperplasia of the lobes on both sides of the prostate	Transurethral resection of the prostate	Survival and good, normal rectal examination, 19 mo
12	71	Difficulty urinating	Without	3.07	Prostatic hyperplasia with calcification	Irregular hyperplasia of the lobes on both sides of the prostate	Transurethral resection of the prostate	Survival and good, normal rectal examination, 24 mo

PSA refers to the detection of total prostate-specific antigen, the reference range is 0.00-4.00 ng/mL.

Table 2 Ultrasound appearance of patients with prostate sclerosing adenopathy

Case	prostate size	Ultrasound image performance
1	5.8 cm × 5.0 cm × 5.8 cm	Full shape, regular margins, normal ratio of internal and external glands, uneven echo, and sonographic image of benign prostatic hyperplasia
2	3.5 cm × 4.1 cm × 3.2 cm	The shape is normal, the edges are regular, the ratio of internal and external glands is normal, and there is a strong echogenic spot in the parenchyma, with a long diameter of about 0.2 cm
3	4.7 cm × 4.5 cm × 3.6 cm	The volume increases, the shape is plump, the internal glands are enlarged, the external glands are compressed and thinned, the parenchyma echoes uniformly, and multiple hyperechoic spots are detected in the parenchyma
4	4.3 cm × 4.3 cm × 4.4 cm	The volume increases, the shape is plump, the internal glands are enlarged, the external glands are compressed and thinned, the parenchymal echo is uneven, and a strong echogenic spot is detected in the parenchyma, with a long diameter of about 0.5 cm
5	5.5 cm × 4.0 cm × 3.7 cm	Enlarged volume, plump shape, enlarged internal glands, thin external glands under compression, uniform parenchymal echo, and sonographic image of benign prostatic hyperplasia
6	5.1 cm × 3.7 cm × 3.2 cm	Enlarged volume, plump shape, enlarged internal glands, thin external glands under compression, uniform parenchymal echo, and sonographic image of benign prostatic hyperplasia
7	4.1 cm × 5.5 cm × 4.7 cm	Full-bodied, enlarged internal glands, thin external glands under pressure, uneven parenchymal echo, and multiple hyperechoic spots within the parenchyma
8	5.7 cm × 5.4 cm × 4.6 cm	The volume increased, the shape was plump, the edges were still regular, the internal glands were enlarged, the external glands were compressed and thinned, and a strong echogenic spot was detected in the parenchyma, with a long diameter of about 0.1cm
9	5.3 cm × 5.1 cm × 3.2 cm	The volume increased, the shape was plump, the edges were still regular, the internal glands were enlarged, the external glands were compressed and thinned, and a strong echogenic spot was detected in the parenchyma, with a long diameter of about 0.6 cm
10	4.9 cm × 4.3 cm × 3.2 cm	Enlarged volume, plump shape, enlarged internal glands, thin external glands under compression, uniform parenchymal echo, and sonographic image of benign prostatic hyperplasia
11	5.5 cm × 4.0 cm × 3.7 cm	Enlarged volume, plump shape, enlarged internal glands, thin external glands under compression, uniform parenchymal echo, and sonographic image of benign prostatic hyperplasia
12	5.5 cm × 4.6 cm × 4.1 cm	The volume increased, the shape was plump, the edges were still regular, the internal glands were enlarged, the external glands were compressed and thinned, and a strong echogenic spot was detected in the parenchyma, with a long diameter of about 0.4 cm

Table 3 Immunohistochemical expression of sclerosing adenopathy

Case	AR	CK5/6	P63	CKH	S100	SMA	Calponin	P504S
1	+	+	++	+++	+	+	-	+
2	+++	+++	+	+	++	++	+	-
3	++	+	+	+	++	+	++	+
4	-	++	++	+++	+	+	++	-
5	-	++	+	++	-	++	+	-
6	+	+	++	+	+	+	+	-
7	++	++	+	+	++	++	+	+
8	+	++	++	+++	+	+	-	-
9	++	++	+	-	+	+	-	++
10	++	+	+	+	+	++	-	++
11	+	++	++	+	+	+	-	+
12	++	+	+	++	+	++	-	++

The interpretation adopted a semi-quantitative counting method, randomly selects 10 representative fields under high magnification (400 x field of view), and calculates the positive rate of cells (the number of positive tumor cells divided by the total number of tumor cells) × 100%, the positive rate of cells Less than 10% is negative, and more than 10% was positive. For positive cells, the percentage of stained cells in the cell count was negative (-), 25%-50% was weakly positive (+), 50%-75% Was medium positive (++), > 75% was strong positive (+++).