Metabolic dysfunction is associated with steatosis but no other histologic features in nonalcoholic fatty liver disease

Table 1 Clinical characteristics of study participants

	MAFLD (n = 61, male 39a)		Non-MAFLD (n = 22, male 15a)		P value
	mean	SD	mean	SD
Age	42.23	12.62	41.23	12.08	0.743
Height (m)	1.66	0.08	1.65	0.08	0.640
Weight (kg)	73.65	13.10	60.31	7.48	< 0.001
BMI	26.43	3.38	21.93	1.09	< 0.001
WC (cm)	89.87	8. 53	80.91	3.93	< 0.001
SBP (mmHg)	126.11	14.50	118.36	10.12	0.009
DBP (mmHg)	77.30	8.68	71.82	8.72	0.016
HR (per min)	77.51	9.10	76.05	8.25	0.492
WBC (× 109/L)	6.22	1.29	5.76	1.25	0.153
Neu%	58.75	8.33	57.42	9.77	0.573
HGB (g/L)	146.20	16.66	149.23	15.57	0.447
PLT (× 109/L)	213.95	70.66	201.18	59.33	0.416
hs-CRP (mg/L)	2.39	2.78	1.92	1.08	0.284
ALB (g/L)	45.14	4.42	43.41	4.32	0.117
GLB (g/L)	28.62	4.37	29.06	3.76	0.656
UA (μmol/L)	372.82	103.65	341.05	73.45	0.128
TG (mmol/L)	2.54	1.63	1.32	0.53	<0.001
TC (mmol/L)	4.89	1.26	4.68	0.91	0.441
LDLC (mmol/L)	2.84	0.93	2.67	0.57	0.334
HDLC (mmol/L)	1.03	0.23	1.15	0.17	0.018
ALT (U/L)	85.43	60.31	65.36	38.65	0.081
AST (U/L)	53.28	31.67	46.32	26.15	0.318
GGT (U/L)	84.36	52.04	60.45	50.48	0.067
ALP (U/L)	100.34	29.11	94.95	25.03	0.412
ChE (U/L)	9756.44	1990.84	8791.95	1987.90	0.059
GLU (mmol/L)	5.56	1.01	4.99	0.63	0.003

^aP value for gender = 0.720.

MAFLD: Metabolic associated fatty liver disease; SD: Standard deviation; BMI: Body mass index; WC: Waist circumference; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; HR: Heart rate; WBC: White blood cell count; Neu: Neutrophil cell; HGB: Hemoglobin; PLT: Platelet; hs-CRP: High-sensitivity C-reactive protein; ALB: Albumin; GLB: Globulin; UA: Uric acid; TG: Triglycerides; TC: Total cholesterol; LDLC: Low-density lipoprotein cholesterol; HDLC: High-density lipoprotein cholesterol; ALT: Alanine aminotransferase; AST: Aspartate transferase; GGT: Gamma-glutamyltransferase; ALP: Alkaline phosphatase; ChE: Cholinesterase; GLU: Fasting glucose.

Table 2 Correlations between degree of steatosis and severity of other hepatic histologic features

Histologic feature	Correlation (r)	P value
Lobular inflammation	0.122	0.272
Portal inflammation	0.005	0.968
Balloon degeneration	0.338	0.002
Liver fibrosis	0.060	0.588
Significant liver fibrosis	0.151	0.172
NASH	0.466	< 0.001

NASH: Nonalcoholic steatohepatitis.