Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration

doi:10.12998/wjcc.v10.i13.3989

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World Journal of Clinical Cases

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Clinical and Translational Research

World J Clin Cases. May 6, 2022; 10(13): 3989-4019
Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.3989

Table 1 Clinical information description of hepatocellular carcinoma patients in The Cancer Genome Atlas

Description	Samples, n = 371	Percentage
Sex
Male	249	67.11
Female	121	32.61
Others	1	0.27
Race
White	184	49.60
Asian	158	42.59
Black or African American	16	4.31
Others	13	3.50
Vital status
Alive	240	64.69
Dead	130	35.14
Others	1	0.27
Age at diagnosis
≥ 60-years-old	197	53.10
< 60-years-old	169	45.55
Others	5	1.35
AJCC pathologic T
T1	180	48.52
T2	92	24.80
T2a	1	0.27
T2b	1	0.27
T3	45	12.13
T3a	29	7.82
T3b	6	1.62
T4	13	3.50
TX	1	0.27
Others	1	0.27
AJCC system for tumor staging
N0	239	64.42
N1	4	1.08
Nx	91	24.53
Others	2	0.54
AJCC system for metastasis staging
M0	265	71.43
M1	4	1.08
Mx	101	27.22
Others	1	0.27
AJCC system for stage
Stage I	170	45.82
Stage II	86	23.18
Stage III	3	0.81
Stage IIIA	65	17.52
Stage IIIB	8	2.16
Stage IIIC	9	2.43
Stage IV	2	0.54
Stage IVA	1	0.27
Stage IVB	2	0.54
Others	25	6.74
Prior malignancy
Yes	35	9.43
No	335	90.30
Others	1	0.27
Treatment or therapy
Yes	38	10.24
No	309	83.28
Others	24	6.47

AJCC: American Joint Committee on Cancer.

Table 2 Correlation of solute carrier family 2 member 1 and solute carrier family 2 expression and clinical prognosis in hepatocellular carcinoma with different clinicopathological factors in Kaplan-Meier plotter

Clinicopathological characteristics	Solute carrier family 2 member 1						Solute carrier family 2 member 2
	Overall survival			Relapse-free survival			Overall survival			Relapse-free survival
	n	Hazard ratio	P value	n	Hazard ratio	P value	n	Hazard ratio	P value	n	Hazard ratio	P value
Sex
Male	246	2.71 (1.73-4.24)	5.40E-06	210	1.36 (0.89-2.08)	0.149	246	0.3 (0.0.19-0.48)	5.80E-08	210	0.5 (0.34-0.75)	0.00068
Female	118	1.89 (1.06-3.38)	0.0287	106	1.61 (0.89-2.9)	0.1109	118	1.48 (0.75-2.93)	0.26	106	0.47 (0.26-0.85)	0.0108
Race
Asian	155	3.14 (1.71-5.77)	1.00E-04	143	1.54 (0.93-2.56)	0.092	155	0.2 (0.11-0.38)	3.80E-08	143	0.41 (0.23-0.73)	0.0017
White	181	1.98 (1.24-3.16)	0.0034	147	1.41 (0.88-2.27)	0.1527	181	0.61 (0.35-1.05)	0.072	147	0.53 (0.33-0.84)	0.0065
Black or African American	17	NA	NA	13	NA	NA	17	NA	NA	13	NA	NA
Sorafenib treatment
Yes	29	2.19 (0.61-7.89)	0.219	22	1.43 (0.59-3.47)	0.4312	29	0.23 (0.06-0.88)	0.0205	22	0.61 (0.24-1.53)	0.2867
None	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Risk factors
Alcohol consumption
Yes	115	1.94 (1-3.78)	0.0464	99	1.61 (0.86-3.03)	0.1365	115	0.42 (0.22-0.8)	0.0063	99	0.37 (0.2-0.67)	0.00061
None	202	2.34 (1.46-3.73)	0.00025	183	1.42 (0.9-2.23)	0.1284	202	0.41 (0.26-0.65)	9.70E-05	183	0.57 (0.34-0.96)	0.0337
Hepatitis virus
Yes	150	2.99 (1.5-5.95)	0.0011	139	1.45 (0.87-2.39)	0.149	150	0.32 (0.16-0.62)	0.0004	139	0.63 (0.37-1.05)	0.0749
None	167	2.39 (1.45-3.96)	0.00046	143	1.92 (1.12-3.32)	0.0168	167	0.47 (0.27-0.83)	0.0083	143	0.41 (0.25-0.68)	0.00038
Pathology
Stage
1	170	2.49 (1.33-4.64)	0.0031	153	1.67 (0.97-2.89)	0.0617	170	0.42 (0.22-0.77)	0.0044	153	0.41 (0.22-0.76)	0.0035
1+2	253	2.09 (1.27-3.44)	0.003	228	1.22 (0.8-1.86)	0.35	253	0.54 (0.33-0.87)	0.0107	228	0.4 (0.23-0.7)	0.00091
2	83	2.12 (0.79-5.64)	0.1258	75	0.5 (0.25-0.99)	0.0424	83	0.34 (0.1-1.14)	0.0665	75	0.56 (0.27-1.14)	0.1046
2+3	166	2.27 (1.39-3.7)	0.00072	145	1.44 (0.89-2.35)	0.1389	166	0.47 (0.26-0.83)	0.0077	145	0.65 (0.41-1.03)	0.064
3	83	2.78 (1.52-5.06)	0.00052	70	2.29 (1.21-4.3)	0.0086	83	0.31 (0.16-0.57)	0.00011	70	0.54 (0.29-0.99)	0.0428
3+4	87	2.67 (1.49-4.78)	6.00E-01	70	2.29 (1.21-4.3)	0.0086	87	0.34 (0.19-0.62)	0.0003	70	0.54 (0.29-0.99)	0.0428
4	5	NA	NA	0	NA	NA	4	NA	NA	0	NA	NA
Grade
1	55	0.67 (0.26-1.7)	0.3967	45	3.65 (0.83-16.1)	0.067	55	0.42 (0.14-1.27)	0.1114	45	0.45 (0.17-1.17)	0.0919
2	174	2.16 (1.29-3.61)	0.0025	149	1.49 (0.89-2.5)	0.1246	174	0.48 (0.28-0.81)	0.0051	149	0.48 (0.29-0.78)	0.0029
3	118	3.11 (1.69-5.7)	0.00012	107	2.16 (1.2-3.86)	0.0082	118	0.3 (0.14-0.66)	0.0014	107	0.62 (0.34-1,.14)	0.1221
4	12	NA	NA	11	NA	NA	12	NA	NA	11	NA	NA
American Joint Committee on Cancer system for tumor staging
1	180	2.31 (1.27-4.21)	0.0047	160	1.51 (0.89-2.58	0.1245	180	0.39 (0.22-0.71)	0.0014	160	0.41 (0.22-0.75)	0.0027
2	90	2.07 (0.79-5.44)	0.1303	80	0.48 (0.25-0.92)	0.023	90	0.45 (0.16-1.29)	0.1272	80	2.02 (0.9-4.56)	0.0836
3	78	3.04 (1.64-5.64)	0.00022	67	2.23 (1.11-4.48)	0.0209	78	0.29 (0.15-0.57)	0.00011	67	0.43 (0.22-0.83)	0.01
4	13	NA	NA	6	NA	NA	13	NA	NA	6	NA	NA
Vascular invasion
None	203	2.18 (91.26-3.78)	0.0043	175	1.32 (0.77-2.28)	0.3144	203	0.39 (0.23-0.66)	0.00027	175	0.45 (0.25-0.83)	0.0089
Micro	90	2.16 (1.01-4.62)	0.042	82	0.46 (0.24-0.88)	0.0163	90	0.32 (0.1-1.08)	0.0531	82	0.73 (0.37-1.44)	0.3593
Macro	16	NA	NA	14	NA	NA	16	NA	NA	14	NA	NA

NA: Not applicable.

Table 3 Correlation analysis between solute carrier family 2 member 1 and solute carrier family 2 and genes markers of immune cells in tumor immune estimation resource

Description	Gene markers	Solute carrier family 2 member 1				Solute carrier family 2 member 2
		None		Purity		None		Purity
		cor	P value	cor	P value	cor	P value	cor	P value
CD8+ T cell
	CD8A	0.216	2.88E-05	0.173	1.27E-03	-0.103	4.85E-02	-0.027	6.15E-01
	CD8B	0.229	8.60E-06	0.195	2.72E-04	-0.199	1.14E-04	-0.138	1.04E-02
T cell (general)
	CD3D	0.241	2.75E-06	0.22	3.73E-05	-0.327	1.33E-10	-0.276	1.88E-07
	CD3E	0.201	1.01E-04	0.162	2.59E-03	-0.165	1.44E-03	-0.087	1.08E-01
	CD2	0.178	5.64E-04	0.138	1.04E-02	-0.194	1.75E-04	-0.121	2.48E-02
B cell
	CD19	0.208	5.50E-05	0.176	1.04E-03	-0.137	8.06E-03	-0.089	9.95E-02
	CD79A	0.099	5.72E-02	0.045	4.01E-01	-0.138	7.84-03	-0.07	1.92E-01
Monocyte
	CD86	0.413	0.00E+00	0.415	8.08E-16	-0.196	1.50E-04	-0.15	5.21E-03
	CD115 (CSF1R)	0.41	0.00E+00	0.408	3.06E-15	-0.175	7.02E-04	-0.126	1.96E-02
Tumor-associated macrophage
	CCL2	0.206	6.86E-05	0.162	2.53E-03	-0.117	2.47E-02	-0.042	4.32E-01
	CD68	0.38	4.24E-14	0.381	2.40E-13	-0.235	5.28E-06	-0.192	3.26E-04
	IL10	0.326	1.26E-10	0.309	4.43E-09	-0.131	1.15E-02	-0.078	1.48E-01
M1 macrophage
	INOS (NOS2)	0.068	1.91E-01	0.052	3.39E-01	0.175	7.12E-04	0.18	7.95E-04
	IRF5	0.142	6.33E-03	0.138	1.05E-02	0.011	8.39E-01	0.003	9.63E-01
	COX2 (PTGS2)	0.32	2.91E-10	0.313	2.80E-09	-0.06	2.45E-01	-0.007	9.03E-01
M2 macrophage
	CD163	0.28	3.94E-08	0.253	1.91E-06	0.046	3.72E-01	0.125	2.00E-02
	VSIG4	0.353	3.65E-12	0.336	1.56E-10	-0.06	2.46E-01	-0.007	8.96E-01
	MS4A4A	0.337	3.49E-11	0.33	3.15E-10	-0.057	2.69E-01	0.01	9.85E-01
	CD66b (CEACAM8)	0.086	9.68E-02	0.084	1.20E-01	-0.036	4.89E-01	-0.027	6.12E-01
	CD11b (ITGAM)	0.428	0.00E+00	0.405	4.71E-15	-0.18	5.06E-04	-0.156	3.75E-03
	CCR7	0.088	8.89E-02	0.016	7.70E-01	-0.032	5.35E-01	-0.045	4.00E-01
	KIR2DL1	0.083	1.09E-01	0.063	2.46E-01	-0.003	9.51E-01	0.019	7.23E-01
	KIR2DL3	0.179	5.16E-04	0.167	1.82E-03	-0.006	9.15E-01	-0.038	4.79E-01
	KIR2DL4	0.234	5.38E-06	0.212	7.12E-05	-0.133	1.06E-02	-0.107	4.78E-02
	KIR3DL1	0.146	4.97E-03	0.12	2.64E-02	0.079	1.30E-01	0.116	3.15E-02
	KIR3DL2	0.098	6.04E-02	0.08	1.38E-01	-0.027	6.02E-01	0.003	9.60E-01
	KIR3DL3	0.06	2.53E-01	0.046	3.91E-01	-0.021	6.91E-01	-0.015	7.87E-01
	KIR2DS4	0.117	2.39E-02	0.13	1.57E-02	0.04	4.37E-01	0.052	3.37E-01
	HLA-DPB1	0.319	4.21E-10	0.296	2.07E-08	-0.191	2.25E-04	-0.138	1.03E-02
	HLA-DQB1	0.221	1.77E-05	0.192	3.35E-04	-0.219	2.09E-05	-0.171	1.43E-03
	HLA-DRA	0.35	5.25E-12	0.326	5.24E-10	-0.117	2.37E-02	-0.055	3.09E-01
	HLA-DPA1	0.338	3.01E-11	0.316	1.92E-09	-0.114	2.88E-02	-0.052	3.34E-01
	BDCA-1 (CD1C)	0.061	2.45E-01	0.024	6.52E-01	0.004	9.40E-01	0.073	1.77E-01
	BDCA-4 (NRP1)	0.357	1.99E-12	0.352	1.70E-11	0.043	4.13E-01	0.087	1.08E-01
	CD11c (ITGAX)	0.382	2.93E-14	0.38	2.50E-13	-0.154	2.93E-03	-0.118	2.86E-02
Th1
	T-bet (TBX21)	0.095	6.88E-02	0.042	4.32E-01	0.025	6.38E-01	0.116	3.07E-02
	STAT4	0.082	1.13E-01	0.045	4.04E-01	-0.106	4.22E-02	-0.058	2.84E-01
	STAT1	0.314	7.29E-10	0.29	4.18E-08	0.023	6.52E-01	0.058	2.84E-01
	IFN-γ (IFNG)	0.237	3.81E-06	0.212	7.39E-05	-0.169	1.09E-03	-0.122	2.31E-02
	TNF-α (TNF)	0.277	6.15E-08	0.257	1.34E-06	-0.147	4.67E-03	-0.092	8.91E-02
Th2
	GATA3	0.248	1.34E-06	0.235	1.03E-05	-0.176	6.76E-04	-0.108	4.52E-02
	STAT6	0.27	1.35E-07	0.255	1.63E-06	0.178	5.68E-04	0.19	3.82E-04
	STAT5A	0.37	1.83E-13	0.338	1.18E-10	-0.097	6.27E-02	-0.055	3.12E-01
	IL13	-0.081	1.19E-01	-0.113	3.56E-02	0.077	1.38E-01	0.09	9.40E-02
Tfh
	BCL6	0.267	2.04E-07	0.281	1.16E-07	0.227	1.08E-05	0.228	1.94E-05
	IL21	0.124	1.65E-02	0.13	1.55E-02	-0.065	2.15E-01	-0.06	2.68E-01
Th17
	IL17A	-0.047	3.68E-01	-0.033	5.46E-01	0.04	4.47E-01	-0.051	3.41E-01
T cell regulatory
	FOXP3	0.068	1.89E-01	-0.039	4.68E-01	0.169	1.07E-03	0.189	4.24E-04
	CCR8	0.286	1.95E-08	0.264	6.44E-07	-0.056	2.79E-01	-0.008	8.86E-01
	STAT5B	0.156	2.63E-03	0.173	1.29E-03	0.402	0.00E+00	0.397	1.83E-14
	TGFβ (TGFB1)	0.314	7.92E-10	0.303	8.83E-09	-0.281	4.30E-08	-0.242	5.53E-06
T cell exhaustion
	PD-1 (PDCD1)	0.256	5.91E-07	0.232	1.31E-05	-0.281	3.50E-08	-0.238	7.71E-06
	CTLA4	0.284	2.57E-08	0.266	5.31E-07	-0.327	1.15E-10	-0.283	8.93E-08
	LAG3	0.156	2.67E-02	0.127	1.83E-02	-0.195	1.66E-04	-0.165	2.15E-03
	TIM-3 (HAVCR2)	0.434	0.00E+00	0.437	1.52E-17	-0.255	6.91E-07	-0.228	1.89E-05
	GZMB	0.176	6.91E-04	0.131	1.51E-02	-0.124	1.70E-02	-0.068	2.10E-01

cor: Correlation coefficient; L10: Interleukin 10; INOS: Nitric oxide synthase 2; IRF5: Interferon regulatory factor 5; COX2: Cytochrome c oxidase subunit II; VSIG4: V-set and immunoglobulin domain containing 4; MS4A4A: Membrane spanning 4-domains A4A; CCR7: C-C motif chemokine receptor 7; KIR2DL1: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; KIR2DL3: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3; KIR2DL4: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4; KIR3DL1: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1; KIR3DL2: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2; KIR3DL3: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3; KIR2DS4: Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4; HLA-DPB1: Major histocompatibility complex, class II, DP beta 1; HLA-DQB1: Major histocompatibility complex, class II, DQ beta 1; HLA-DRA: Major histocompatibility complex, class II, DR alpha; HLA-DPA1: Major histocompatibility complex, class II, DP alpha 1; BDCA-4: Neuropilin 1; T-bet: T-box transcription factor 21; STAT4: Signal transducer and activator of transcription 4; STAT1: Signal transducer and activator of transcription 1; IFN-γ: Interferon gamma; TNF-α: Tumor necrosis factor; GATA3: GATA binding protein 3; STAT6: Signal transducer and activator of transcription 6; STAT5A: Signal transducer and activator of transcription 5A; IL13: Interleukin 13; BCL6: BCL6 transcription repressor; IL21: Interleukin 21; IL17A: Interleukin 17A; FOXP3: Forkhead box P3; CCR8: C-C motif chemokine receptor 8; STAT5B: Signal transducer and activator of transcription 5B; TGFβ: Transforming growth factor-beta; PD-1: Programmed cell death 1; CTLA4: Cytotoxic T-lymphocyte associated protein 4; LAG3: Lymphocyte activating 3; TIM-3: Hepatitis A virus cellular receptor 2; GZMB: Granzyme B; Tfh: Follicular helper T.

Table 4 Correlation analysis between solute carrier family 2 member 1 and solute carrier family 2 and genes markers of immune cells in gene expression profiling interactive analysis

Description	Gene markers	Solute carrier family 2 member 1		Solute carrier family 2 member 2
Description	Gene markers	cor	P value	cor	P value
CD8+ T cell
	CD8A	0.24	3.10E-06	-0.084	1.10E-01
	CD8B	0.26	3.20E-07	-0.13	1.40E-02
T cell (general)
	CD3D	0.18	5.10E-04	-0.23	1.10E-05
	CD3E	0.15	4.00E-03	-0.11	3.90E-02
	CD2	0.17	1.50E-03	-0.12	2.60E-02
B cell
	CD19	0.22	1.60E-05	-0.073	1.60E-01
	CD79A	0.036	4.90E-01	-0.59	2.60E-01
Monocyte
	CD86	0.39	1.50E-14	-0.16	1.70E-03
	CD115 (CSF1R)	0.36	1.40E-12	-0.14	5.40E-03
Tumor-associated macrophage
	CCL2	0.16	2.30E-03	-0.13	1.50E-02
	CD68	0.27	9.20E-08	-0.14	6.50E-03
	IL10	0.32	2.50E-10	-0.095	6.70E-02
M1 macrophage
	INOS (NOS2)	-0.031	5.50E-01	0.2	1.20E-04
	IRF5	0.14	7.40E-03	0.044	4.00E-01
	COX2 (PTGS2)	0.16	1.50E-03	-0.028	5.90E-01
M2 macrophage
	CD163	0.31	7.00E-10	-0.13	1.40E-02
	VSIG4	0.36	1.10E-12	-0.12	1.80E-02
	MS4A4A	0.29	1.50E-08	-0.11	2.80E-02
	CD66b (CEACAM8)	0.074	1.60E-01	-0.018	7.30E-01
Neutrophil
	CD11b (ITGAM)	0.28	5.80E-08	-0.074	1.60E-01
	CCR7	0.039	4.60E-01	-0.028	5.90E-01
Natural killer cell
	KIR2DL1	0.087	9.40E-02	-0.059	2.60E-01
	KIR2DL3	0.13	1.40E-02	-0.05	3.40E-01
	KIR2DL4	0.18	7.10E-04	-0.12	2.00E-02
	KIR3DL1	0.086	9.70E-02	-0.058	2.70E-01
	KIR3DL2	0.069	1.90E-01	-0.0081	8.80E-01
	KIR3DL3	0.08	1.30E-01	-0.068	1.90E-01
	KIR2DS4	0.044	4.00E-01	0.02	7.10E-01
Dendritic cell
	HLA-DPB1	0.25	1.40E-06	-0.16	2.20E-03
	HLA-DQB1	0.14	8.10E-03	-0.19	2.60E-04
	HLA-DRA	0.26	6.00E-07	-0.15	5.00E-03
	HLA-DPA1	0.2	8.00E-05	-0.12	2.30E-02
	BDCA-1 (CD1C)	0.12	2.40E-02	-0.044	4.00E-01
	BDCA-4 (NRP1)	0.23	6.80E-06	-0.037	4.80E-01
	CD11c (ITGAX)	0.24	2.00E-06	-0.13	1.40E-02
Th1
	T-bet (TBX21)	0.088	9.00E-02	-0.058	2.70E-01
	STAT4	0.0027	9.60E-01	-0.041	4.40E-01
	STAT1	0.13	1.10E-02	0.017	7.50E-01
	IFN-γ (IFNG)	0.19	3.30E-04	-0.1	4.70E-02
	TNF-α (TNF)	0.12	2.00E-02	-0.1	5.40E-02
Th2
	GATA3	0.31	2.10E-09	-0.13	1.20E-02
	STAT6	0.15	4.80E-03	0.19	2.40E-04
	STAT5A	0.2	8.20E-05	-0.07	1.80E-01
	IL13	-0.025	6.30E-01	-0.01	8.40E-01
Tfh
	BCL6	0.1	4.70E-02	0.24	2.70E-06
	IL21	0.072	1.70E-01	-0.044	3.90E-01
Th17
	IL17A	-0.022	6.70E-01	0.071	1.80E-01
T cell regulatory
	FOXP3	-0.036	4.90E-01	0.17	1.40E-03
	CCR8	0.16	1.90E-03	-0.082	1.20E-01
	STAT5B	0.073	1.60E-01	0.43	0.00E+00
	TGFβ (TGFB1)	0.24	2.10E-06	-0.25	1.40E-06
T cell exhaustion
	PD-1 (PDCD1)	0.08	1.20E-01	-0.12	2.00E-02
	CTLA4	0.17	1.10E-03	-0.18	7.20E-04
	LAG3	0.23	7.60E-06	-0.19	3.30E-04
	TIM-3 (HAVCR2)	0.22	1.30E-05	-0.17	1.30E-03
	GZMB	0.17	8.10E-04	-0.16	2.20E-03

cor: Correlation coefficient; L10: Interleukin 10; INOS: Nitric oxide synthase 2; IRF5: Interferon regulatory factor 5; COX2: Cytochrome c oxidase subunit II; VSIG4: V-set and immunoglobulin domain containing 4; MS4A4A: Membrane spanning 4-domains A4A; CCR7: C-C motif chemokine receptor 7; KIR2DL1: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; KIR2DL3: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3; KIR2DL4: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4; KIR3DL1: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1; KIR3DL2: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2; KIR3DL3: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3; KIR2DS4: Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4; HLA-DPB1: Major histocompatibility complex, class II, DP beta 1; HLA-DQB1: Major histocompatibility complex, class II, DQ beta 1; HLA-DRA: Major histocompatibility complex, class II, DR alpha; HLA-DPA1: Major histocompatibility complex, class II, DP alpha 1; BDCA-4: Neuropilin 1; T-bet: T-box transcription factor 21; STAT4: Signal transducer and activator of transcription 4; STAT1: Signal transducer and activator of transcription 1; IFN-γ: Interferon gamma; TNF-α: Tumor necrosis factor; GATA3: GATA Binding protein 3; STAT6: Signal transducer and activator of transcription 6; STAT5A: Signal transducer and activator of transcription 5A; IL13: Interleukin 13; BCL6: BCL6 transcription repressor; IL21: Interleukin 21; IL17A: Interleukin 17A; FOXP3: Forkhead box P3; CCR8: C-C motif chemokine receptor 8; STAT5B: Signal transducer and activator of transcription 5B; TGFβ: Transforming growth factor-beta; PD-1: Programmed cell death 1; CTLA4: Cytotoxic T-lymphocyte associated protein 4; LAG3: Lymphocyte activating 3; TIM-3: Hepatitis A virus cellular receptor 2; GZMB: Granzyme B; Th: T helper; Tfh: Follicular helper T.

Citation: Peng Q, Hao LY, Guo YL, Zhang ZQ, Ji JM, Xue Y, Liu YW, Lu JL, Li CG, Shi XL. Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration. World J Clin Cases 2022; 10(13): 3989-4019
URL: https://www.wjgnet.com/2307-8960/full/v10/i13/3989.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i13.3989