Recurrence of infectious mononucleosis in adults after remission for 3 years: A case report

Table 1 Case reports related to adult infectious mononucleosis

Ref.	Description of cases
Miyamoto et al[16], 1998	This case report described an adult patient with chronic and active EBV infection. Hepatitis was prolonged after EBV infection
Cunha et al[17], 2017	This case report described a 20-yr-old female patient diagnosed with IM and exhibiting the classic symptoms of infectious mononucleosis. However, she developed unexplained dyspnea and hypoxia. Further laboratory tests confirmed that she was coinfected with Mycoplasma pneumoniae. The report did not explain the reason for her hypoxia. She slowly recovered after respiratory quinolone therapy
Busch et al[18], 2014	An 18-yr-old man was reported to have severe IM complicated with fulminant hepatic failure, splenic rupture, and esophageal necrosis
Kang et al[19], 2009	Two cases were reported. The first case was a 20-yr-old man with acute hepatitis secondary to IM. The second case was a 24-yr-old woman with acute hepatitis secondary to IM concomitantly infected with hepatitis A
Higuchi et al[9], 2007	A 54-yr-old man presented with fever, swelling of the oral mucosa and tongue, dispersed pulmonary infiltrations, systemic lymphadenopathy, and splenomegaly. He had a history of recurrent IM-like symptoms for at least 1 yr. Mantle cell lymphoma was diagnosed by biopsy of the cervical lymph node. Anti-EBV antibody titers indicated a reactivation of chronic infection with this virus
Goltzman et al[20], 2000	This case report included two adult patients. Neither of them had the classic IM symptoms such as fever, pharyngitis, and lymphadenopathy, but both experienced complications of EBV infection
Akashi et al[21], 1993	This report described the case of a 43-yr-old man with severe IM and HHV-6 coinfection, with a 7-d history of fever and 5-d history of progressive, generalized skin eruption. Liver dysfunction was present, with an increase in the levels of aspartate aminotransferase
Lawee et al[10], 2007	A 22-yr-old female patient with mild EBV infection associated with mixed liver disease

EBV: Epstein–Barr virus; HHV: Human herpesvirus; IM: Infectious mononucleosis.