Gupta P, Das GC, Bansal A, Samanta J, Mandavdhare HS, Sharma V, Naseem S, Gupta V, Yadav TD, Dutta U, Varma N, Sandhu MS, Kochhar R. Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis. World J Clin Cases 2022; 10(1): 91-103 [PMID: 35071509 DOI: 10.12998/wjcc.v10.i1.91]
Corresponding Author of This Article
Pankaj Gupta, MD, Associate Professor, Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. pankajgupta959@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 7, 2022; 10(1): 91-103 Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.91
Table 1 Baseline demographic details and outcome parameters
Characteristic
Overall cohort
Age, yr (mean ± SD)
40 ± 13.6
Sex (%)
Males
64.5
Females
35.5
Etiology, n (%)
Alcohol
79 (51)
Gallstones
63 (40.6)
ERCP
6 (3.9)
Idiopathic
5 (3.2)
Hyperparathyroidism
2 (1.3)
Co-morbidities, n (%)
32
Diabetes mellitus
19 (59.4)
Hypertension
21 (65.6)
Coronary artery disease
8 (25)
Chronic obstructive airway disease
14 (43.7)
Obesity, n (%)
18 (11.6%)
Severity, n (%)
Moderately severe
72 (46.4)
Severe
83 (53.5)
Pain to PCD interval, d (median)
24
Site of collection, n (%)
Lesser sac
94 (62.6)
Paracolic gutter
28 (18.7)
Lesser sac and paracolic gutter
16 (10.7)
Perisplenic
4 (2.7)
Perihepatic
3 (2)
Pelvic
5 (3.3)
Infected necrosis, n (%)
75 (36.7)
Organ failure, n (%)
100 (64.5)
Length of hospital stay, d (mean ± SD)
22 ± 19.3
Length of ICU stay, d (mean ± SD)
6.1 ± 10.1
Surgery, n (%)
24 (15.4)
Endoscopic drainage, n (%)
7 (4.5)
Mortality, n (%)
32 (20.6)
Table 2 Group statistics
Parameters
Overall cohort (n = 155)
Characteristics
Compared variable
Group I
Group II
P value
Number
109
46
Pain to PCD interval
Mean
39.8
54.1
0.249
Site of collection (%)
Lesser sac
64.2
52.2
0.464
Paracolic
16.5
21.7
Lesser sac + paracolic
11
8.7
Procalcitonin
Mean
3.2
5.4
0.331
Collection size
Mean
11.4
11.5
0.974
Catheter size
< 12F
23
8
0.598
> 12F
86
38
RAC severity
Moderately severe
62
11
< 0.001
Severe
47
35
Infected necrosis
No
71
27
0.447
Yes
38
19
Organ failure
No
43
11
0.076
Yes
66
34
Table 3 Serial white blood cell count and neutrophil-lymphocyte ratio
Day
n
Median
IQR (25%-75%)
WBC
0
155
14.9
9.9-20.7
1
110
12.3
8.9-17.4
2
151
11.6
8.3-17.6
3
102
12.4
8.9-16.2
NLR
0
140
8.2
5.2-14.1
1
88
7.2
4.4-12
2
136
6.4
4.1-11.9
3
89
6.6
3.8-12.1
Table 4 Area under the curve for serial white blood cell count and neutrophil-lymphocyte ratio for differentiating responders from non-responders to percutaneous catheter drainage
Time point
WBC
NLR
Baseline (0)
0.508
0.401
24 h (1)
0.602
0.682
48 h (2)
0.468
0.407
72 h (3)
0.416
0.427
Citation: Gupta P, Das GC, Bansal A, Samanta J, Mandavdhare HS, Sharma V, Naseem S, Gupta V, Yadav TD, Dutta U, Varma N, Sandhu MS, Kochhar R. Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis. World J Clin Cases 2022; 10(1): 91-103