Acquired coagulation dysfunction resulting from vitamin K-dependent coagulation factor deficiency associated with rheumatoid arthritis: A case report

Table 1 Blood coagulation function test results

Hospitalization days	PT	INR	FBG	APTT	TT	D-D	FDPs	AT	PTA
2	38.6	3.97	4.85	109.8	16.9	0.89	-	-	19
4	18.4	1.53	5.09	53.9	16.4	0.94	< 4.0	80	54
8	16.9	1.37	4.21	55.7	17.3	0.81	< 4.0	67	62
11	16.4	1.31	4.82	55.5	16.7	1.28	4.2	75	65

Normal reference range: Prothrombin time: 11.5-14.5 s; international normalized ratio: 0.5-1.2; fibrinogen: 2.0-4.0 g/L; activated partial thromboplastin time: 29-42 s; thrombin time: 14-19 s; D-D: < 0.5 μg/mL FEU; FDPs: < 0.5 μg/mL; AT: 80%-120%; PTA: 75%-125%. Hospitalization day 1 was November 27, 2019; day 2: November 28, 2019; day 4: November 30, 2019; day 8: December 4, 2019; day 11: December 7, 2019. PT: Prothrombin time; INR: International normalized ratio; FBG: Fibrinogen; APTT: Activated partial thromboplastin time; TT: Thrombin time; D-D: D-dimer; FDPs: Fibrin degradation products; AT: Antithrombin; PTA: Prothrombin activity.

Table 2 Blood coagulation factor activity test results

Hospitalization days	II	V	VII	VIII	IX	X	XI	XII
2	7	122	-	-	-	6	-	-
9	36	96	95	168	71	25	86	40

Normal reference range: II: 70%-120%; V: 70-%120%; VII: 55%-170%; VIII: 60%-150%; IX: 60%-150%; X: 70%-120%; XI: 60%-150%; XII: 50%-150%. Hospitalization day 1: November 27, 2019; day 2: November 28, 2019; day 9: December 5, 2019.

Table 3 Routine urine test results

Hospitalization days	RBCs	WBCs	Urinary protein	Nitrite	Specific gravity	Ketonuria	Urinary bilirubin	Urine glucose
3	3+	3+	3+	Positive	> 1.030	2+	3+	±
9	3+	1+	1+	Negative	< 1.009	Negative	Negative	Negative

Normal reference range: Red blood cells: Negative; white blood cells: Negative; urinary protein: Negative; nitrite: Negative; specific gravity: 1.015-1.025; ketonuria: Negative; urinary bilirubin: Negative; urine glucose: Negative. Hospitalization day 1: November 27, 2019; day 2: November 29, 2019; day 9: December 5, 2019. RBCs: Red blood cells; WBCs: White blood cells.