Robot-assisted retroperitoneal laparoscopic excision of perirenal vascular tumor: A case report

Abstract

BACKGROUND

A vascular tumor is a benign tumor with unique clinical and pathological features. Perirenal vascular tumor is extremely rare and has not yet been reported. Clinically, it manifests as soreness and swelling. Color ultrasound and renal angiography illustrated the perirenal mass, which was closely connected with the kidney and the surrounding tissues and organs. Histology showed extensive embedded perirenal fat, and thin-walled vascular tissue displayed a pink stain due to red blood cells.

CASE SUMMARY

Herein, a case of robot-assisted retroperitoneal laparoscopic excision of a perirenal vascular tumor is reported. Analysis of the clinical, biological, and histological features of the perirenal vascular tumor can provide an in-depth understanding of the disease, which provides a theoretical and practical basis for better diagnosis and treatment.

CONCLUSION

This study contributes to a practical basis for the diagnosis and treatment of perirenal hemangiom.

Key Words: Kidney, Vascular tumor, Treatment, Robot-assisted surgery

Core tip: Perirenal vascular tumor is an extremely rare disease. We summarized the clinical manifestations, imaging features, and pathological characteristics of a perirenal vascular tumor in a clinical case, and successfully removed the tumor using robotic surgery without complications. This provides a practical model for the diagnosis and treatment of this disease.

INTRODUCTION

Vascular tumors are rare benign cystic tumors that commonly occur in the mouth and face. Originating from the mesenchymal tissue, vascular tumors are mostly microvascular lymphatic malformations caused by dysplasia in the embryonic stage or residual tissue, resulting in the obstruction of fluid reflux, expansion, and protrusion, and are classified as hemangiomas and lymphangiomas. These tumors are mostly benign, and no malignant or invasive characteristics have been observed[1]. The majority of vascular tumors have a slow growth rate, and the size of the tumor increases with age. Typically, they do not regress spontaneously. The most common complications include spontaneous or traumatic hemorrhage, rupture, and infection[2]. According to trauma or surgical history, they are classified into primary and secondary vascular tumors[3]. Primary vascular tumors constitute the most commonly reported type in the clinic. Vascular tumors are common in children and adolescents with a reported hemolymphangioma incidence of 1.2%-2.8% in newborns. The incidence before the age of 2 years was > 90%, while 60% of newborns showed symptoms at birth[4,5]. Lesions can be single, multiple, or diffused, occurring in any part of the body, especially in the loose connective tissue.

Herein, we report the case of a primary perirenal vascular tumor, which is a rare occurrence in the clinic. Only 2 cases of retroperitoneal angiocarcinoma were reported previously[6,7]. Such cases are often subjected to surgical excision in the clinic[8,9]. Currently, experience in the diagnosis and treatment of perirenal vascular tumors is lacking. Herein, we report a case of perirenal vascular tumor from clinical, imaging, and pathological aspects, which could provide elaborate information regarding the study and treatment of vascular tumors.

CASE PRESENTATION

Chief complaints

A 38-year-old female was admitted to the Urological Department of the First Affiliated Hospital of Nanchang University after 37 d of soreness and swelling in the left waist.

History of present illness

The patient initially showed symptoms on November 13, 2018, which were not relieved with the change in body posture. The patient experienced radiating pain, nausea, vomiting, frequent urination, urgent urination, and gross hematuria. She underwent an abdominal color ultrasound at the Jiangxi Provincial Breast Hospital (ultrasound No. 9000022433). The compression type change of the cystic mass in the left middle upper abdominal region and the left side of the abdominal aorta seemed to be connected with the left kidney. On November 27, double renal computed tomography (CT) angiography was performed and routine blood and biochemical examinations were conducted on December 20 at the First Affiliated Hospital of Nanchang University. Subsequently, robot-assisted retroperitoneal laparoscopic excision was performed to excise the perirenal vascular mass on December 25 under general anesthesia.

History of past illness

She was healthy without any previous history of surgery, hypertension, or diabetes.

Physical examination

Physical examination indicated no pressing or percussion pain in both kidneys.

Laboratory examinations

Routine blood and biochemical examinations to assess tumor markers showed no obvious abnormalities (Table 1).

Table 1 Preoperative laboratory test results.

Laboratory examination
Hemoglobin	134 g/L	Globulin	24.7 g/L
Red blood cells	4.64 × 1012/L	Alanine aminotransferase	11.0 U/L
White blood cells	5.21 × 109/L	Aspartate aminotransferase	18.0 U/L
Neutrophilic granulocytes	2.56 × 109/L	Alpha fetoprotein	1.36 ng/mL
Lymphocytes	2.28 × 109/L	Carcinoembryonic antigen	0.60 ng/mL
Blood platelets	316 × 109/L	Carbohydrate antigen 12-5	41.63 U/mL
Urea	3.9 mmol/L	Carbohydrate antigen 15-3	12.30 U/mL
Cr	52.4 μmol/L	Carbohydrate antigen 19-9	10.54 U/mL
Na	138.0 mmol/L	Carbohydrate antigen 724	7.19 U/mL
K	4.0 mmol/L	Prothrombin time	9.9 s
Albumin	45.3 g/L	Thrombin time	17.7 s

Imaging examinations

Imaging illustrated a low-density cystic shadow in the left kidney hilus with a lacy edge and a maximum size of approximately 7.7 cm × 10.1 cm (Figure 1A). The density was uniform, the surroundings were compressed, the adjacent left upper ureter was compressed, and left hydronephrosis showed dilation (Figure 1B); this was considered to be a lymphangioma.

Figure 1 Preoperative angiography of the double renal artery. A: Cystic low-density shadow in the left renal hilus with a lacy edge; B: Mass adjacent to the abdominal aorta, wrapping the left side, compressing the surrounding tissue, the upper segment of the left ureter, and dilated hydronephrosis in the left kidney.

FINAL DIAGNOSIS

Preoperative diagnosis was a left perirenal mass. Pathological diagnosis was a perirenal vascular tumor.

TREATMENT

As the patient’s left perirenal mass was huge and closely related to the left kidney, the upper segment of the left ureter, and the left abdominal aorta, the Da Vinci robotic surgical system was selected as it is characterized by a wide operating range, high operating accuracy, and a flexible manipulator operation. Intraoperatively, the mass showed irregular cystic growth close to the surrounding organs and tissues, and was approximately 10 cm × 8 cm in size (Figure 1). Using the flexible mechanical arm of the Da Vinci surgical robotic system, caution was taken to avoid damage to the left kidney, left ureter, abdominal aorta, and peritoneum. The tumor was cystic in the field of view, a small cut was made, the clear cystic fluid was aspirated, and the tumor was completely removed. The wound was repeatedly rinsed with distilled water, and sufficient hemostasis was achieved. After the specimen was excised, a drainage tube was placed beside the left kidney, and the incision was sutured to complete the operation. Intraoperative blood loss was 30 mL, and postoperative routine blood and biochemical results were normal. The drainage tube in the left kidney was removed after 3 d, and the patient was discharged 6 d after surgery. Postoperative pathology showed a perirenal vascular tumor (Figure 2).

Figure 2 Perirenal vascular tumor specimen and microscopic image. A: Grayish yellow irregular fat tissue 9 cm × 7 cm × 1.2 cm in size was visualized; B: Cystic cavity tissue of different sizes, containing eosin or red blood cells, vascular hyperplasia, partial dilatation, and deformity were observed under the microscope (HE, × 100).

OUTCOME AND FOLLOW-UP

Reexamination was performed at 7 mo postoperatively. Color Doppler ultrasound was performed at the Nanchang Kangqiao Health Physical Examination Center on July 30, 2019, which illustrated a crystal in the left kidney (Figure 3).

Figure 3 Re-examination results of color ultrasound six months postoperatively. Both kidneys were of normal size and shape and had a clear outline. The bright spot in the left kidney did not show a posterior acoustic shadow. No dilatation was observed in the double ureters.

DISCUSSION

In the early stage, vascular tumors are usually asymptomatic; however, most are detected due to their enlarged size leading to compression in the affected site. Diagnosis revealed clearly defined hypoechoic cystic masses by B-ultrasound in a honeycomb or septum formation. CT scan showed a relatively low-density uniform lesion. In the vascular tumor mainly with lymph, CT showed a clear boundary without obvious enhancement. In the vascular tumor mainly with vessels, CT displayed an unclear boundary, and an enhancement in the arterial stage of different degrees was observed. With regard to treatment, surgery is the first option for almost all vascular tumors to prevent or relieve the symptoms of tumor compression.

Our patient with a perirenal vascular tumor is extremely rare. Due to enlargement of the tumor and compression on adjacent organs, the corresponding symptoms were an abdominal mass, soreness, and swelling at the waist. The putative mechanisms are as follows: (1) Congenital malformation of the vascular system; (2) Mutation or deletion of gene expression in the body; and (3) Related to the pathogenesis of previous renal diseases, but the specific mechanism requires further investigation. As the disease is rare, preoperative diagnosis is difficult. Currently, ultrasound and CT are mainly used to determine the range of the mass and its correlation with adjacent organs[10]. If the mass is rich in blood supply, further identification by magnetic resonance imaging is required. In this case, color ultrasound and abdominal CT were the first options for the diagnosis and localization of the perirenal vascular tumor. During imaging, perirenal vascular tumors have pathological features of benign tumors. Therefore, only a few cases have been reported, and different manifestations are essential to further clarify the imaging features of the disease.

Perirenal vascular tumors are benign lesions which develop slowly. If the tumor is small, and the patient does not present obvious clinical symptoms, conservative treatment, such as anti-infective agents can be administered, and when renal function is normal, this is followed by regular observation. If the tumor volume is large, and the renal parenchyma is compressed, hydronephrosis, renal hypertension, and other complications are actively treated by surgery[11]. Surgical excision is the most effective treatment for perirenal vascular tumors. The principle of surgery is to completely excise the lesion and to maximally retain normal renal tissue. Nonetheless, regular reexamination and follow-up are recommended despite the benign nature of vascular tumors.

Since the first Da Vinci robotic surgery in 1988, robotic surgery has been rapidly promoted and applied[12]. It is a favored method in urology due to the small incision, accuracy, and flexible and a stable intraoperative procedure[13]. A recent study reported that the Da Vinci robot could effectively reduce the incidence of perioperative complications in urology and improve the safety and feasibility of surgery[14,15]. When the tumor is large and the base is wide, the Da Vinci robot can expose a wider visual field than traditional surgery, overcoming the disadvantages of traditional deep surgery where the tumor and anatomical space cannot be observed from multiple angles. The lesion can be removed more precisely and steadily, avoiding the difference between the handwork and feel in traditional surgery. This technique greatly reduces surgical trauma and hastens postoperative recovery[16]. The Da Vinci robot results in excellent 3D vision with a flexible and super artificial manual operating system and a novel surgical mode, cooperating with increasingly updated artificial intelligence to continuously promote the development of surgery.

CONCLUSION

A perirenal vascular tumor is a rare disease. We summarized the clinical manifestations, ultrasound, CT imaging, and pathological features of a perirenal vascular tumor, and recommended surgical excision. The present study provides a theoretical and practical basis for the recognition and diagnosis of perirenal vascular tumors.