Systematic Reviews Open Access
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2024; 12(1): 119-129
Published online Jan 6, 2024. doi: 10.12998/wjcc.v12.i1.119
Nasogastric tube syndrome: A Meta-summary of case reports
Deven Juneja, Department of Critical Care Medicine, Max Super Speciality Hospital, New Delhi 110017, India
Prashant Nasa, Department of Critical Care Medicine, NMC Specialty Hospital, Dubai 7832, United Arab Emirates
Gunjan Chanchalani, Department of Critical Care Medicine, Karamshibhai Jethabhai Somaiya Hospital and Research Centre, Mumbai 400022, India
Ravi Jain, Department of Critical Care Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur 302022, Rajasthan, India
ORCID number: Deven Juneja (0000-0002-8841-5678); Prashant Nasa (0000-0003-1948-4060); Gunjan Chanchalani (0000-0001-8429-8526); Ravi Jain (0000-0001-9260-479X).
Author contributions: Juneja D and Nasa P conceptualized and designed the article; Juneja D, Nasa P, Chanchalani G, and Jain R performed acquisition of data, analysis and interpretation of data, and drafted the article; Chanchalani G and Jain R revised the article; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deven Juneja, DNB, MBBS, Director, Department of Critical Care Medicine, Max Super Speciality Hospital, 1 Press Enclave Road, Saket, New Delhi 110017, India. devenjuneja@gmail.com
Received: October 28, 2023
Peer-review started: October 28, 2023
First decision: December 5, 2023
Revised: December 7, 2023
Accepted: December 18, 2023
Article in press: December 18, 2023
Published online: January 6, 2024
Processing time: 66 Days and 3.7 Hours

Abstract
BACKGROUND

Since its description in 1790 by Hunter, the nasogastric tube (NGT) is commonly used in any healthcare setting for alleviating gastrointestinal symptoms or enteral feeding. However, the risks associated with its placement are often underestimated. Upper airway obstruction with a NGT is an uncommon but potentially life-threatening complication. NGT syndrome is characterized by the presence of an NGT, throat pain and vocal cord (VC) paralysis, usually bilateral. It is potentially life–threatening, and early diagnosis is the key to the prevention of fatal upper airway obstruction. However, fewer cases may have been reported than might have occurred, primarily due to the clinicians' unawareness. The lack of specific signs and symptoms and the inability to prove temporal relation with NGT insertion has made diagnosing the syndrome quite challenging.

AIM

To review and collate the data from the published case reports and case series to understand the possible risk factors, early warning signs and symptoms for timely detection to prevent the manifestation of the complete syndrome with life-threatening airway obstruction.

METHODS

We conducted a systematic search for this meta-summary from the database of PubMed, EMBASE, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and Google scholar, from all the past studies till August 2023. The search terms included major MESH terms "Nasogastric tube", "Intubation, Gastrointestinal", "Vocal Cord Paralysis", and “Syndrome”. All the case reports and case series were evaluated, and the data were extracted for patient demographics, clinical symptomatology, diagnostic and therapeutic interventions, clinical course and outcomes. A datasheet for evaluation was further prepared.

RESULTS

Twenty-seven cases, from five case series and 13 case reports, of NGT syndrome were retrieved from our search. There was male predominance (17, 62.96%), and age at presentation ranged from 28 to 86 years. Ten patients had diabetes mellitus (37.04%), and nine were hypertensive (33.33%). Only three (11.11%) patients were reported to be immunocompromised. The median time for developing symptoms after NGT insertion was 14.5 d (interquartile range 6.25-33.75 d). The most commonly reported reason for NGT insertion was acute stroke (10, 37.01%) and the most commonly reported symptoms were stridor or wheezing 17 (62.96%). In 77.78% of cases, bilateral VC were affected. The only treatment instituted in most patients (77.78%) was removing the NG tube. Most patients (62.96%) required tracheostomy for airway protection. But 8 of the 23 survivors recovered within five weeks and could be decannulated. Three patients were reported to have died.

CONCLUSION

NGT syndrome is an uncommon clinical complication of a very common clinical procedure. However, an under-reporting is possible because of misdiagnosis or lack of awareness among clinicians. Patients in early stages and with mild symptoms may be missed. Further, high variability in the presentation timing after NGT insertion makes diagnosis challenging. Early diagnosis and prompt removal of NGT may suffice in most patients, but a significant proportion of patients presenting with respiratory compromise may require tracheostomy for airway protection.

Key Words: Nasogastric tube; Nasogastric tube syndrome; Ryle’s tube; Sofferman syndrome; Vocal cord paralysis

Core Tip: Nasogastric tube (NGT) insertion is a commonly employed procedure in hospitalised patients. Although it is considered a minor and safe procedure, complications may occur due to its invasive nature. Immediate complications while NGT insertion may be easily recognised, but long-term complications may be missed and are rarely reported. Most of the complications are minor and can be rapidly detected, but rarely, life-threatening complications like NGT syndrome have also been reported. NGT syndrome has been described decades ago, but till now, very few adult cases have been reported in the literature. Timely recognition and a simple intervention of NGT removal may be life-saving, and most patients may show complete recovery. However, a significant proportion of these patients may require tracheostomy for airway protection until the vocal cord palsy recovers.



INTRODUCTION

Nasogastric tube (NGT) insertion is a common procedure for hospitalised patients. Although NGT insertion is considered a simple procedure, it may lead to complications because of its invasive nature. Elderly, critically ill and those with underlying comorbidities may be prone to develop these complications, but these are the patients who may also benefit the most from NGT insertion. The commonly reported complications of NGT include malposition, knotting or coiling of the tube, and local trauma or bleeding[1,2]. Most of these complications occur during NGT insertion and are generally mild and easily recognised. Severe complications like oesophageal rupture have also been reported. In patients with long-standing NGT tubes, ulceration or necrosis of nasal alar, epistaxis, congestion, rhinosinusitis, and acute otitis media have also been reported[2-4]. Other complications associated with NGT include impaired lower oesophageal sphincter function, leading to increased gastroesophageal reflux (GER) and aspiration pneumonitis[2]. However, certain long-term complications associated with NGT, like the NGT syndrome, may be challenging to recognise and rarely reported (Tables 1 and 2)[5-22].

Table 1 Base-line parameters of patients developing “nasogastric tube syndrome”.
Case number
Author
Year of publication
Country of origin
Number of cases
Age
Sex
Comorbidities
Immunocompromised
Indication for NGT insertion
1Sofferman and Hubbell[5]1981United States460FemaleCecal cancerNonePerioperative
2Sofferman and Hubbell[5]1981United States474MaleNoneNoneCVA
3Sofferman and Hubbell[5]1981United States434MaleNoneNoneSevere TBI
4Sofferman and Hubbell[5]1981United States475FemaleOsler-Weber-Rendu disease, AnemiaNonePost-operative
5Sofferman et al[6]1990United States428MaleDM, HTN, CKDYes (post-renal transplantation)Perioperative period
6Sofferman et al[6]1990United States442MaleDM, HTN, CKD, CADYes (post-renal transplantation)Perioperative period
7Sofferman et al[6]1990United States436MaleDM, CKDNoAMS
8Sofferman et al[6]1990United States445FemaleDM, CKDYes (post-renal transplantation)Acute pancreatitis
9Apostolakis et al[7]2001United States277MaleNoneNoToxic megacolon
10Apostolakis et al[7]2001United States273MaleDM, HTN, COPDNoGI bleed
11To et al[8]2001Hong Kong163MaleNANAPerioperative period
12Nehru et al[9]2003Kuwait160MaleDM, HTNNoAcute stroke
13Sanaka et al[10]2004Japan185MaleHTNNoGastrointestinal obstruction
14Isozaki et al[11]2005Japan273MaleNANADementia
15Isozaki et al[11]2005Japan277MaleNANAAcute stroke
16Marcus et al[12]2006Israel172MaleNoneNoTraumatic brain injury
17Vielva del Campo et al[13]2010Spain170FemaleDM, ParkinsonismNoAcute stroke
18Kim et al[14]2015Korea186FemaleDM, HTN, ParkinsonismNASevere pneumonia with septic shock
19Sano et al[15]2016Japan176MaleNoNoGI obstruction
20Perera[16]2018Sri Lanka176FemaleNANAAcute stroke
21Kanbayashi et al[17]2021Japan177MaleHTN, AFNoAcute stroke
22Yildiz et al[18]2021Türkiye173MaleNANAPerioperative
23Taira et al[19]2022Japan178MaleNoNAAMS
24Cui et al[20]2023China165FemaleHTN, ParkinsonismNoCervical cord injury
25Nihira et al[21]2023Japan186FemaleNoneNoAcute stroke
26Paul et al[22]2023Qatar278FemaleDM, HTNNoPerioperative
27Paul et al[22]2023Qatar279FemaleDM, CADNoAMS
Table 2 Clinical course of patients with nasogastric syndrome.
Case numberPresenting symptomsType of feed NGTDays after which symptoms developedSide of vocal cords involvedLaryngoscopyBiopsyCultureTherapeutic interventionsTracheostomyOutcomeSequalae
1Voice change, throat painNG3B/LVocal cord edema, post cricoid abcessNoneNoneNG removal, steroids, antibioticsYesAliveRecovered in 7 d and discharged
2Sore throat, stridorNG8B/LVocal cod edema, arytenoid edema, post cricoid ulcerationNoneNoneNG removalYesAliveRecovery in 14 d
3Throat discomfort, aspiration,NG30B/LVocal cord edema and paralysis, postcricoid edema1NoneNG removal, gastrostomy placementYesAliveGastrostomy support required even after 12 wk follow up
4Stridor, troat painNG9B/LVocal cord paralyis and arytenoid edemaNoneNoneRemoval of tubeYesAliveRecovered completely 15 d after tube removal
5Stridor, throat painNG18B/LVocal cord edema and post cricoid ulcerNACoagulase positive staph aureusNGT removalYesAliveOne month after trach – VC mobile, but residual arytenoid edema
6Throat pain, feverNG5Vocal cord edema and post cricoid ulcerNAStreptococcusNGT removalNoAlive
7StridorNA16Vocal cord edema and post cricoid ulcerNANoneYesDied
8Stridor, feverNGNAB/LB/L vocal cord edemaNACandida albicansNGT removalYesAlive54 d after – both VC recovered sufficient abductor mobility and decannulation done
9StridorNG2B/LImpaired vocal cord abduction bilaterally. With edema. Postcricoid necrotic ulcer was noted, 1.5 cm in widthNoMixed bacterial growthNGT removalYesAliveNo recovery till 1 month
10SOBNG2B/LIsolated and complete abductor dysfunction of his vocal cords. With edema. Postcricoid ulcerationNoMixed bacterial growthNGT removal, steroidsYesAliveDecannulated after 5 wk
11Cough, sore throatNG9Left VC paralysisLeft arytenoid fold swollenNoNoneNGT removalNoAliveNone
12IncidentalNG140LtLeft- inhibited abductor movementYesNoneNG removalYesAlivePersistent VC palsy
13Stridor, SOBLong intestinal tube4B/LMild arytenoid edemaNoNoneRemoval of tubeYesAliveDecannulated after 3 wk
14StridorNG730B/LB/L VC edemaNoNoneNANoDied
15StridorNG75B/LB/L VC edemaNoNoneFrequent NG changesNoDied
16Stridor, tachypnea, SOBNG30B/LRight VC paralysis, impaired left VC mobility, B/L edemaNoNoneNGT removal, steroidsNoAliveNone
17Stridor, SOBNG35B/LBilateral arytenoid edemaNoNoneNGT removalYesYesDecannualted after 20 d
18Stridor, desaturation, AMSNG15B/LImpaired abduction of the Vocal cordsNoNoneNGT removal, steroidsNoAliveNone
19Stridor, throat pain, desaturationLong intestinal tube6B/LB/L arytenoid edemaNoNoneNGT removalYesAliveDecannulated after 4 wk
20Stridor, throat pain, Respiratory distressNG14B/LBilateral vocal cord palsy with severely compromised airway.NoNoneNGT removal, steroidsYesAliveImproved after 4 wk
21StridorNG14B/LB/L VC palsyNoNoneNGT removalNoAliveNone
22Stridor, slurring of speech, sore throat, difficulty in swallowing, desaturationNG7B/LB/L vocal cord edemaNoNoneNGT removal, steroidsYesAliveA month to complete recovery
23Wheezing, hoarsenessNasointestinal ileus tube3B/LLeft arytenoid edema and erythemaNoNoneTube removal, steroidsNoAliveNone
24IncidentalNG15B/LSevere edemaNoNoneInhaled steroidsYesAliveDecannulated after 5 wk
25StridorNG105B/LBL laryngeal edemaNoNoneNGT removalYesAliveNone
26DesaturationNG180RtRt VC palsyNoNoneNeb steroidsNAAliveNone
27StridorNG760RtRt VC palsyNoNoneNeb steroidsNAAliveNone

The NGT syndrome is a serious and potentially life-threatening complication of NGT insertion. Even though the first description of this syndrome was in a case series of 12 patients published by Iglauer and Molt[23] in 1939, the term NGT syndrome was coined by Sofferman et al[6] in 1990. They described NGT syndrome as the development of throat pain and abductor dysfunction of vocal cords (VC) secondary to the presence of the NGT. It is suspected to result from ulceration and necrosis of the posterior cricoid region, leading to VC abduction paralysis[6].

The exact cause of NGT syndrome remains unknown. However, multiple mechanisms have been postulated, a combination of which may lead to the development of NGT syndrome. The first reason could be the dynamic and delicate larynx being constantly irritated by the semi-rigid NGT when the patient swallows or coughs. Secondly, the tonic contractile cricopharyngeus muscle continually presses the NGT against the posterior cricoid cartilage lamina, forming pressure ulcers. Thirdly, gravity pulls the larynx posteriorly in a supine patient, causing the NGT to be stuck between the rigid cricoid cartilage and the anterior cervical spine[5]. Finally, another proposed mechanism is the ischemia secondary to the compression of blood vessels supplying the posterior cricoarytenoid muscle by the NGT[11]. All these may lead to NGT causing persistent pressure, trauma and irritation on the posterior cricoid lamina, leading to ischemic necrosis, ulceration, and infection. This infection and necrosis of the posterior cricoid cartilage affect the function of the posterior cricoarytenoid muscles, which in turn affects the capacity of the larynx to abduct the VC, leading to respiratory compromise[5,11].

Diagnosis of NGT syndrome may be missed because of lack of awareness, non-specific symptomatology and delayed presentation after NGT insertion. Hence, only a few cases have been reported in the literature. Through this meta-summary, we intend to review and collate the available case reports and series data to understand the possible risk factors, signs and symptoms, and the clinical course of patients with NGT syndrome.

MATERIALS AND METHODS

We conducted a systematic search for this meta-summary from the databases of PubMed, EMBASE, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and Google scholar, from all the past studies till August 2023. The search terms included major MESH terms "Nasogastric tube", "Intubation, Gastrointestinal", "Vocal Cord Paralysis", and Syndrome. Further, it was filtered for the case reports published in the English language and on adult (> 18 years) humans. We manually screened all the search results and included the relevant literature for NGT syndrome. Duplicate articles from different search databases were excluded manually (Figure 1).

Figure 1
Figure 1 The preferred reporting items for systematic reviews and meta-analyses flow diagram of the selected literature.

All the case reports and case series were evaluated, and the data were extracted for patient demographics, clinical symptomatology, diagnostic and therapeutic interventions, clinical course and outcomes. A datasheet for evaluation was further prepared.

Data Analysis

We prepared and evaluated the datasheet with the help of Excel and Microsoft Office 2019. Categorical variables were presented as frequency and percentage. Mean (SD) or median [interquartile range (IQR)] was used for continuous variables as appropriate. We applied a non-parametric correlational statistical test to test the non-parametric statistical hypothesis, as found appropriate. A P value of < 0.05 was deemed significant. Unless otherwise indicated, all the statistical analyses were done using SPSS (version 25.0, IBM SPSS Inc., Chicago, IL, United States). Tabulation and final documentation were done using MS Office software (MS Office 2019, Microsoft Corp, WA, United States).

RESULTS

Twenty-seven cases, from five case series and 13 case reports, of NGT syndrome were retrieved from our search, and published in literature till August 2023[6-22]. There was male predominance (17, 62.96%), and maximum number of cases were reported from the United States (10, 37.04%) and Japan (7, 25.93%). The age at presentation ranged from 28 to 86 years, with 22 (81.48%) aged 60 years or above. The median reported age was 73 years (IQR 61.5-77.0). Ten patients had diabetes mellitus (37.04%), and nine were hypertensive (33.33%). Other commonly reported comorbidities included chronic kidney disease (2, 7.4%), parkinsonism (2, 7.4%) and coronary artery disease (1, 3.7%). Only three (11.11%) patients were reported to be immunocompromised. The median time for developing symptoms after NGT insertion was 14.5 d (IQR 6.25-33.75 d).

The most commonly reported reason for NGT insertion was acute stroke (10, 37.01%), followed by peri-operative insertion (7, 25.93%) and altered mental status (3, 11.11%). The most commonly reported symptoms were stridor or wheezing 17 (62.96%), throat pain (7, 25.9%) and breathlessness (4, 14.8%). In 21, 77.78% of cases, bilateral VC were affected but in 3 patients (11.1%), only unilateral involvement was reported.

The only treatment instituted in most patients (21, 77.78%) was removing the NGT. However, few patients were also treated with systemic (7, 25.9%) or inhaled (4, 14.8%) steroids. Most patients (17, 62.96%) required tracheostomy for airway protection. But 8 of the 23 survivors recovered within five weeks and could be decannulated. Three patients (11.11%) were reported to have died (Table 3).

Table 3 Clinical course of patients with nasogastric syndrome.
Indication for NGT
Number of patients, n (%)
Acute stroke10 (37.04)
Peri-operative period7 (25.93)
Altered mental status4 (14.81)
Gastrointestinal obstruction2 (7.41)
Traumatic brain or spinal cord injury2 (7.41)
GI bleed1 (3.7)
Acute pancreatitis1 (3.7)
Severe pneumonia with septic shock1 (3.7)
Toxic megacolon1 (3.7)
Presenting symptoms
        Stridor17 (62.96)
        Sore throat/throat pain7 (25.93)
        Shortness of breath4 (14.8)
        Desaturation3 (11.11)
        Speech disturbance4 (14.8)
        Swallowing difficulty3 (11.11)
        Cough1 (3.7)
        Altered sensorium1 (3.7)
        Incidental2 (7.41)
Type of feed NGT
        Nasogastric23 (85.19)
        Long intestinal tube1 (3.7)
        Naso-intestinal ileus tube2 (7.41)
        NA1 (3.7)
Vocal cord involved
        Bilateral21 (77.78)
        Left2 (7.41)
        Right2 (7.41)
Therapeutic interventions
        Tube removal21 (77.78)
        Systemic steroids7 (25.93)
        Inhalational steroids4 (14.81)
        Frequent change of nasogastric tube1 (3.7)
Tracheostomy procedure
        Yes17 (62.96)
        No8 (29.63)
        NA2 (7.41)
Final outcome
        Alive23 (85.19)
        Dead3 (11.11)
        NA1 (3.7)
Reported sequelae of NGT syndrome
        Improved after 3 wk4 (14.81)
        Improved after 4 wk2 (7.41)
        Partial improvement after 4 wk1 (3.7)
        Improved after 5 wk2 (7.41)
        Improved after 8 wk2 (7.41)
        No recovery till 4 wk1 (3.7)
        Persistent vocal cord palsy2 (7.41)
        None reported8 (29.63)
DISCUSSION

The present review included data from 27 reported cases with a diagnosis of NGT syndrome, published in last five decades. More than 80% of patients were aged 60 years and above and 37.04% were reported to be diabetics. There was a considerable heterogeneity in the timing of onset of symptoms from NGT insertion (ranging 2 d to 2 years). In most of the patients, the only intervention required was NGT removal. Even though 62.96% required tracheostomy for airway protection, most of them showed complete recovery, with 8 of 23 survivors getting tracheostomy decannulation within five weeks.

NGT syndrome is a rare but potentially life-threatening complication of NGT insertion. It may be stipulated that the incidence of NGT syndrome may be much higher than reported and the diagnosis is largely missed, as many patients may have minor symptoms or are misdiagnosed. Further, many patients requiring NGT are too sick to report any symptoms and hence, the diagnosis largely depends on the suspicion of treating physicians. Wolff and Kessler[24], evaluated larynges of 149 patients by performing a post-mortem, who have had NGT in situ for more than 48 h and reported that 35% had post-cricoid ulcers present[24]. This may suggest, in critically ill patients requiring NGT for more than 48 h, the incidence may be much higher, warranting a high index of suspicion in such patients.

The non-specific symptoms related to NGT syndrome are frequently missed or attributed to other common diseases like asthma or infection. Throat pain has been described as an important and early presenting complaint and is a component of the classical triad defined by Sofferman et al[6] However, critically ill patients or those with altered mental status may not be able to complain of pain and hence the diagnosis may be missed or delayed. In our review, throat pain was reported in only 7, 25.93% of patients, and stridor was the most commonly reported symptom, present in almost 17, 62.96% of patients. As most of these patients had neurological dysfunction or were critically ill, throat pain might not have been reported. Hence, the presence of stridor or wheeze in a patient with NGT should alert the treating physician towards the possibility of NGT syndrome. Symptoms like breathlessness, desaturation or respiratory distress develop late and are suggestive of advanced disease requiring prompt medical intervention. If early signs are missed, patients with NGT syndrome may present with life-threatening respiratory distress, which may require emergency tracheostomy to maintain the airway.

The presence of comorbidities may also affect the incidence of NGT syndrome. Diabetes Mellitus has been reported to increase the risk of developing NGT syndrome, which was also reported to be present in 10, 37.04% of cases in our review[6]. The other reported risk factors include the presence of GER leading to an acidic environment in the post-cricoid region and the presence of NGT at the level of the lower oesophageal sphincter which may reduce its function[25].

Classically NGT syndrome has been described to affect both the VC[6]. However, as the awareness regarding this syndrome increased over the years, multiple unilateral varieties of NGT syndrome have been described[8,9,22]. Three patients (11.11%) in our review had only unilateral VC involvement.

Symptoms of NGT syndrome have been shown to develop even two days after NGT insertion[2] but may be delayed up to two years[11]. This heterogeneity in presentation and lack of predictability makes the diagnosis more challenging.

Diagnosis of NGT syndrome requires direct visualisation of the VC and the post-cricoid area. Culture or biopsy may not be required for the diagnosis but may be helpful in ruling out any secondary infection and instituting appropriate antibiotics. As the diagnosis requires an invasive procedure, patients with minor symptoms like sore throat and hoarseness of voice may not warrant such a procedure and hence may be missed.

The only treatment instituted in most of the patients (73.9%) was the removal of the NGT. Oral ingestion of food should be avoided as it may lead to aspiration due to VC palsy. Re-insertion of a softer NGT of a smaller size has also been shown to prevent the development of NGT syndrome[17]. Although NGT syndrome has been reported even with smaller size tubes, the effect of size remains unknown because most of the case reports on NGT syndrome did not mention the size of NGT used[22]. Although it seems prudent that the use of a smaller and softer NGT, if the patient’s condition allows, may prevent the development of NGT syndrome.

Even though inhaled or intravenous steroids were used in some patients, its role remains debatable. However, it may be instrumental in reducing inflammation and may provide early symptomatic relief in patients with severe symptoms. But, the risk of secondary infections must be kept in mind while prescribing corticosteroids in critically ill patients. Hence, corticosteroids if used, should be for short duration and considering risk-benefit in patients with severe airway obstruction.

Complications of NGT syndrome include acute respiratory failure and the formation of retro-cricoid abscesses. Airway compromise secondary to VC palsy may necessitate tracheostomy for maintaining the airway. The presence of an endotracheal tube may prevent VC healing. Hence, tracheostomy may be preferred in such patients. The tracheostomy tube should be removed only after the resolution of VC palsy, which, in most of these cases, occur between few weeks to months. In our review, even though most of the patients required tracheostomy, they could be successfully decannulated over the next few weeks.

There are several strengths to our analysis. We have included all the published cases on NGT syndrome till date. As we selected only adult cases, the data collected is more homogenous and applicable to adult healthcare. This being a meta-summary of case series and case reports, it has some inherent limitations. The data was collected from case series and case reports, and thus, there was no control arm, studies were heterogeneous, and prone to high risk of bias and missing data. This may affect the generalisability of the results. The present study is a meta-summary of published case reports and series, and there are significant deficits of data in these papers, and data regarding any dysphagia assessment, probe usage, or assistance provided by rehabilitation teams was not present and scarcely reported. Hence, this could not be commented on in our study. However, as these are very important aspects of understanding the natural history and course of NGT syndrome, we also recommend including these data in future research or report papers.

CONCLUSION

NGT syndrome is an uncommon clinical complication of a very common clinical procedure. However, an underreporting is possible because of misdiagnosis, or lack of awareness among clinicians. Patients in early stages and with mild symptoms may be missed. Further, high variability in the timing of presentation after NGT insertion makes diagnosis challenging. Hence, a high index of suspicion is warranted to make a diagnosis. Early diagnosis and prompt removal of NGT may suffice in most patients, but a significant proportion of patients presenting with respiratory compromise may require tracheostomy for airway protection. The long-term outcomes remain favourable with complete resolution of symptoms in most of the cases.

ARTICLE HIGHLIGHTS
Research background

The risks associated with nasogastric tube (NGT) placement are often underestimated. Upper airway obstruction with a NGT is an uncommon but potentially life-threatening complication.

Research motivation

NGT syndrome is potentially life–threatening, and early diagnosis is the key to prevention of fatal upper airway obstruction. Lack of specific signs and symptoms and inability to prove temporal relation with NGT insertion, has made diagnosing the syndrome quite challenging.

Research objectives

To review and collate the data from the published case reports and case series, to understand the possible risk factors, early warning signs and symptoms for timely detection to prevent the manifestation of the complete syndrome with life-threatening airway obstruction.

Research methods

We conducted a systematic search, from the database of PubMed from all the past studies till August 2023. The search terms included major MESH terms "Nasogastric tube", "Intubation, Gastrointestinal", "Vocal Cord Paralysis", and “Syndrome”. Further, it was filtered for the case reports published in the English language and on adult (> 18 years) humans.

Research results

Twenty-seven cases, from five case series and 13 case reports, of NGT syndrome were retrieved. There was male predominance (62.96%), and the age at presentation ranged from 28 to 86 years. The median time taken for developing symptoms after NGT insertion was 14.5 d (interquartile range 6.25-33.75 d). The most commonly reported reason for NGT insertion was acute stroke (37.01%), and the most commonly reported symptoms were stridor or wheezing (62.96%). The only treatment instituted in most of patients (77.78%) was removing the NGT. The majority (62.96%) of patients required tracheostomy for airway protection, but only three deaths were reported.

Research conclusions

NGT syndrome is an uncommon clinical complication of a very common clinical procedure. Early diagnosis and prompt removal of NGT may suffice in most patients, but a significant proportion of patients presenting with respiratory compromise may require tracheostomy for airway protection.

Research perspectives

A high index of suspicion is required for diagnosis of NGT syndrome. Further studies may aid in identifying the risk factors and help in early diagnosis.

Footnotes

Provenance and peer review: Invited article; Externally peer reviewed.

Peer-review model: Single blind

Specialty type: Medicine, research and experimental

Country/Territory of origin: India

Peer-review report’s scientific quality classification

Grade A (Excellent): 0

Grade B (Very good): 0

Grade C (Good): C

Grade D (Fair): 0

Grade E (Poor): 0

P-Reviewer: Arakawa-Sugueno L, Brazil S-Editor: Li L L-Editor: A P-Editor: Li L

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