Mortal condition in an unusual localization, analysis of isolated tongue and tongue base abscesses

Abstract

BACKGROUND

Tongue abscess (TA) is a very rare clinical condition and its treatment is very important. Surgical drainage is at the forefront in the treatment. Our study includes patients with tongue and tongue base abscesses.

AIM

To discuss the clinical and laboratory findings of these patients emphasizing the underlying causes and treatment options with the largest patient series in the English literature.

METHODS

We included patients with isolated TA who applied to our clinic between January 1, 2020 and January 1, 2023. Those who lack the recorded data, those who are not between the ages of 18-66, those who have not undergone surgery-interventional procedure, and those who have infection and/or abscess in another place were excluded from the study.

RESULTS

There were two female (18%) and nine male (82%) patients in our series consisting of 11 patients. Their ages ranged from 18 to 66, and the mean ± SD was 48.63 ± 16.3. Considering the localization of the abscess, three anterior abscesses (27%), two lateral abscesses (18%), and six abscesses at the base of the tongue (54%) were detected.

CONCLUSION

Tongue abscesses can cause acute upper airway obstruction and respiratory collapse. It may be necessary to act quickly for the tracheotomy procedure and this procedure can usually be performed under local anesthesia as intubation cannot be achieved. When we encounter an abscess in an unexpected organ, difficulties may be encountered in the management of the patient.

Key Words: Tongue; Abscess; Neutrophils; Blood platelets; Lymphocytes

Core Tip: Tongue abscess is a very rare disease due to the anatomical and physiological structure of the tongue. The rarity of the disease can make it difficult to diagnose. Particular attention should be paid to airway obstruction, sepsis, and mediastinitis. Surgical drainage should be performed in abscesses larger than one centimeter.

INTRODUCTION

Tongue abscess (TA) is a very rare disease, potentially dangerous due to possible airway obstruction. The anatomical, vascular and muscular structure of the tongue and the unique antibacterial properties of saliva promote prevention of infection. Foreign bodies and immunosuppression may predispose to infection. TA may show symptoms such as dysphagia, dyspnea, pain, referred pain, fever. Especially tongue base abscesses should be taken into consideration as they can cause sudden respiratory collapse. Drainage should be applied in the treatment of tongue abscesses[1]. Most tongue abscesses are unifocal and located in the anterior two-thirds of the tongue. Abscesses in the posterior part of the tongue (including the tongue base) mostly occur as diseases involving the lingual tonsil, infected thyroglossal duct cysts extending to the base of the tongue, ectopic thyroid gland, or dissemination of apical infections of the first or second molar teeth[2]. Most of the articles on the subject remained as case reports, and the patient series found in the literature are limited in number. A maximum of six patient series have been reported[3].

There are authors in the literature reporting that the ratios of neutrophil (NEU) and lymphocyte (LYMPH) values to each other are useful in predicting cardiac diseases, cancer, infective diseases and length of hospital stay[4-6]. There are also studies on infectious diseases involving the ratio of platelets (PLTs) and LYMPHs to each other, diseases with ischemic neuropathy hypothesis, allergic rhinitis and asthma, neonatal sepsis, congenital branchial cysts[7-10]. We aimed to discuss this article with up-to-date information, which includes the largest patient series and allows to look at the disease with different laboratory parameters.

MATERIALS AND METHODS

We included patients with isolated TA who applied to our clinic between January 1, 2020 and January 1, 2023. The patients were divided into two groups. Anterior and lateral tongue abscesses were named as group 1 (anterolateral) and tongue base abscesses were named as group 2. Patients’ age, gender, location of the abscess, contrast-enhanced computed tomography (CT) results (Figures 1A and B), white blood cell (WBC, μL) count, NEU (μL) count, LYMPH (μL) count, PLT (μL) number, NEU/LYMPH ratio (NLR), PLT/LYMPH ratio (PLR), C-reactive protein (CRP, m/L) value, erythrocyte sedimentation rate (ESR, m/h) value, abscess culture results, surgeries and interventional procedures (Figures 2A and B), underlying causes, additional systemic diseases, smoking history, length of hospital stay, antibiotics used, antibiotics used before admission, pathology results were recorded. A retrospective archive search was conducted for the study. Those who lack the recorded data, those who are not between the ages of 18-66, those who have not undergone surgery-interventional procedure, and those who have infection and/or abscess in another place were excluded from the study. Pediatric patients were excluded from the study. None of the patients had a history of foreign body or piercing. TA drainage and tracheotomy surgical procedures were performed under local anesthesia, and penrose drains were placed in all patients who underwent surgical drainage. In patients with tongue base abscess, the operation was started with tracheotomy under local anesthesia, followed by external drainage of the abscess with a transhyoidal approach under general anesthesia. Transoral tongue base abscess drainage; it has not been tried because the abscesses are closer to the hyoid bone and in deeper localizations, the external method is preferred (Table 1). All of our patients were decannulated (postoperative 10^th d) after treatment. All of our patients were given intravenous treatment for 14 d as standard, and 600 m of oral cefdinir was given daily for 14 d at discharge. Ethics committee approval was obtained for our study (09/286). Written and verbal consent was obtained from all patients participating in the study.

Figure 1 Contrast-enhanced computed tomography results. A: Contrast-enhanced tomography image of lateral tongue abscess; B: Massive tongue base abscess.

Figure 2 Surgeries and interventional procedures. A: Intraoperative view of surgically drained tongue abscess; B: Postoperative view of tongue abscess with penrose drain placed.

Table 1 Clinical information of patients with tongue abscess.

Patient	Surgery/puncture	Incision-drainage/incision-drainage and tracheotomy	Hospitalization time (d)
1	Surgery	Incision-drainage	6
2 (HIV positive)	Surgery	Incision-drainage	4
3	Surgery	Incision-drainage	9
4	Surgery	Incision-drainage	8
5	Surgery	Incision-drainage and tracheotomy	11
6	Surgery	Incision-drainage and tracheotomy	9
7	Surgery	Incision-drainage and tracheotomy	8
8 (diabetes mellitus)	Puncture		6
9 (hypothyroidism)	Surgery	Incision-drainage	7
10	Surgery	Incision-drainage and tracheotomy	10
11 (intravenous heroin addict)	Surgery	Incision-drainage	4

HIV: Human immunodeficiency virus.

RESULTS

There were 2 female (18%) and 9 male (82%) patients in our series consisting of 11 patients. Their ages ranged from 18 to 66, and the mean ± SD was 48.63 ± 16.3. Considering the localization of the abscess, three anterior abscesses (27%), two lateral abscesses (18%) in group 1, six abscesses at the base of the tongue (54%) in group 2 were detected. Contrast-enhanced CT was performed in all abscess patients, and abscess sizes ranged from 10 to 45 mm, the mean ± SD was 22.9 ± 10.79 mm. Four of the patients (36%) had additional disease; acquired immune deficiency syndrome was found in one patient, diabetes mellitus (DM) in one patient, hypothyroidism in one patient, and intravenous heroin addiction in one patient. WBC ranged from 4240 to 20470, the mean ± SD was 11330 ± 4079. NEU ranged from 220 to 17870 and the mean ± SD was 8282 ± 3839. LYMPH ranged from 1020 to 3740, the mean ± SD was 2018 ± 872. PLT ranged from 172000 to 457000, the mean ± SD was 274818 ± 94437. The NLR ranged from 1.65 to 17.51, and the mean ± SD was 5.05 ± 4.43. The PLR ranged from 60.9 to 304.41, and the mean ± SD was 159.67 ± 81.27. CRP ranged from 4.9 to 178.6 and the mean ± SD was 43.59 ± 54.34. ESR ranged from 11 to 62, the mean ± SD was 35.81 ± 16.88. Bacterial growth was observed as a result of abscess culture in 82% of patients (9 patients). Streptococcus viridans was detected in two patients, Streptococcus pneumoniae in two patients, Streptococcus spp. in two patients, Methicillin-sensitive coagulase negative staphylococci in one patient, Candida krusei in one patient, Bacteroides spp. in one patient. Abscesses of all patients were drained, incision-drainage was preferred in 10 patients, and needle aspiration was preferred in one patient. Tracheotomy was preferred in four (36%) patients to secure the airway. Five of the patients are smokers and have poor oral hygiene (45%). Etiology could be detected in four (36%) of the patients. Extension of the infected thyroglossal duct cyst to the base of the tongue in two of the patients, abscess formation 24 h after the coronavirus disease 2019 mRNA vaccine in one patient, and intravenous heroin addiction in one patient were detected. Hospitalization time ranged from 4 to 11 d, and the mean ± SD was 7.45 ± 2.29. Ampicillin-Sulbactam was given to 10 of our patients and Piperacillin-Tazobactam was given to 1 of our patients. No antibiotic revision was required in any of our patients. Antifungal treatment was also given to our patient who overgrown Candida krusei. Six of our patients (54%) used Amoxicillin-clavulanate before applying to the hospital. Pathology was sent to 10 of our patients, and cytology (a patient with needle aspiration) was sent in one of our patients. In all of the pathology results, an appearance compatible with chronic active inflammation and abscess was detected. In addition, dense actinomyces colonies were detected in one patient.

Three patients in group 1 had a history of additional diseases, one patient in group 2. There is no statistically significant difference between groups regarding the frequency of additional diseases (P = 0.545). There was no statistically significant difference between the groups in terms of WBC, NEU, LYMPH, PLT, NLR, PLR, CRP, ESR, and hospitalization time (P > 0.05 for all, respectively 0.361, 0.465, 0.584, 0.361, 0.855, 0.584, 0.273, 0.201, 0.08).

DISCUSSION

TA is a disease that is usually seen in immunocompromised people and is very rare in healthy individuals. TA is a rare clinical condition that is seen much less frequently than deep neck infections (DNIs), which are common diseases in otorhinolaryngology clinics.

Therefore, we believe that it is not correct to state the incidence for the disease. The tongue is resistant to infection with additional antimicrobial effect of the saliva. The differential diagnosis of tongue abscesses includes tumor, cyst, hematoma, hyperpituitarism, hypothyroidism, lingual thyroid, and ectopic lymphoid tissues. Generally, abscesses are unilateral and located in the anterior 2/3 of the tongue. Painful swelling, dysphagia, odynophagia, speech disorder, tongue pain - headache, high fever, dyspnea are among the symptoms[1,11]. There are 2 types of abscesses, superficial and deep. Deep abscesses of the tongue are observed in cases that go down to the muscle tissue planes. Patients present with more severe symptoms and a toxic appearance. Tracheotomy may be considered for patients with dyspnea CT, magnetic resonance imaging can be used in the diagnosis of patients. After the correct diagnosis, the safety of the airway, incision-drainage is important. Antibiotics treatments should cover streptococci, staphylococci and anaerobes. Since aspiration alone is an inadequate treatment method, it should not be preferred over drainage[2]. We preferred it in one of our patients because the abscess was located anteriorly and was small in size. To prevent complications, it is important for the clinician to take a decisive stance and act quickly if drainage and elective local tracheotomy are indicated.

In the literature, comorbidity was not observed in most patients, and the most common symptoms are painful tongue, odynophagia, and tongue swelling. Tracheotomy is performed in approximately one third of the patients[3]. Antoniades et al[12] reported two immunocompromised patients presenting with severe respiratory distress. And in two patients with severe immune problems, the predisposing factors were dental intervention and odontogenic infection. Palpation can be a valuable diagnostic tool in posterior lingual abscesses. Isolated medical treatment may be sufficient for abscesses < 1 cm. Only medical treatment works for subcentimetric abscess. Posterior lingual abscesses may result in sepsis, mediastinitis, and fatal airway obstruction[13]. Although rates for airway obstruction, sepsis, and mediastinitis are given for DNIs in the literature[11], unfortunately these cannot be stated clearly for TA. We think that airway obstruction and sepsis may be a bigger problem for TA. Because the tongue is a muscular organ, it does not have potential spaces and fascias like the neck, and therefore the increased abscess size will directly cause collapse in the upper airway. Another important situation is that the tongue base is one of the most important anatomical formations of swallowing and upper airway breathing. The size of the abscess between the vallecula and tongue base may cause direct passage collapse and make possible elective or semi-elective intubations impossible. It should not be forgotten that there is always the possibility of emergency tracheotomy in this patient group, and if the indication occurs, this situation can be dramatic for the patient and the doctor. We think that due to the high blood supply and arterial network of the tongue, it is more susceptible to septic microemboli and the rate and probability of leading to sepsis may be higher than DNIs. Our study, which included 11 consecutive patients, is the largest series in the literature. Contrary to the literature, posterior lingual abscess (54%) was observed more frequently in our study and appeared as swelling at the base of the tongue. It should not be forgotten that there may be tumoral lesions that occupy space in the differential diagnosis of the disease and contrast-enhanced imaging methods can always be preferred. Contrast-enhanced CT was performed in all of our abscess patients. Abscess sizes were found to be 22.9 mm on average. All patients had odynophagia and dysphagia. Additional disease was detected in four of our patients (36%). Incision-drainage was applied to all of our patients except one. In one of our patients, only puncture was performed. Tracheotomy was performed in 36% of our patients. Five of our patients were smokers and had poor oral hygiene. Human immunodeficiency virus (HIV) infection was present in one of our patients, DM in one, and intravenous heroin use in one caused immunosuppression. Although we cannot provide sufficient data on isolated medical treatment since we do not have an abscess < 1 cm, we think that incision-drainage would be appropriate because the tongue contains dense muscle tissue and may obstruct the airway. It is necessary not to be very conservative about tracheotomy in patients with tongue base localization, because sudden collapse will result in death. Poor oral hygiene and smoking were observed as a remarkable factor in tongue abscesses. Since it is an atypical disease, an infectious disease specialist should be asked about empirical antibiotics within the framework of a multidisciplinary approach and revised antibiotics based on the bacteriological result of the abscess content.

NLR was found useful in comparing two conditions that regressed with medical treatment, such as abscess requiring incision-drainage and microabscess-cellulitis[4]. NLR has been identified as a variable predicting hospitalization time in odontogenic head and neck infections[5]. CRP is elevated in case of infection and the half-life is between 5 and 7 h. WBC determines total WBC count, values > 10000 suggest infection. In inflammatory conditions, neutrophils usually increase while LYMPHs decrease. Therefore, NLR is a more reliable marker than the total leukocyte count in the evaluation of inflammation. NLR is a good marker especially in odontogenic infections[6]. PLR is a new inflammatory marker. In a study conducted with patients with DNI, NEU and PLR values differed between patient groups requiring and not requiring airway management. NEU and PLR were found to be statistically significantly higher in patients requiring airway management[7]. It has been stated that PLR is a parameter that can also be used in neonatal sepsis[8]. NLR, PLR are important biochemical markers shown to be increased in bacterial inflammation. NLR and PLR averages of group 1 were higher than group 2. The remarkable point in our study is that patients with intravenous heroin addiction (highest) and hypothyroidism had the highest values in terms of PLR. These two patients were ranked 2^nd (hypothyroidism) and 3^rd (intravenous heroin addict) in terms of NLR. In patients with TA, we may encounter low immune system and/or additional disease status with high PLR, NLR values. NLR and PLR are among the recent trending fields of study in otorhinolaryngology and are thought to be useful in predicting hospitalization time and bacterial inflammation status, especially in DNIs patients. In particular, the fact that NLR is a significant marker in odontogenic DNIs may be the subject of a new and original study with a large case series in the group of patients with TA who have predisposing factors of poor oral hygiene. Systemic additional diseases that cause immunosuppression and diseases that create an insidious clinical course, such as HIV, can cause serious problems in cases of TA. We routinely monitor hemogram, biochemical parameters and CRP in all our patients to whom we perform drainage and puncture, and request a preoperative serological marker for viral diseases such as hepatitis B, C and HIV, which are transmitted through blood and contact. Depending on the status of additional diseases, we take the advice of the relevant branch and treat this serious illness with a multidisciplinary approach.

CONCLUSION

TA is a very rare disease due to the anatomical and physiological structure of the tongue. The rarity of the disease can make it difficult to diagnose. Particular attention should be paid to airway obstruction, sepsis, and mediastinitis. Surgical drainage should be performed in abscesses larger than one centimeter.

ARTICLE HIGHLIGHTS

Research background

Discussing the treatment methods and complications of this rare disease will contribute to science. Its rarity may make the disease difficult to diagnose and cause increased mortality.

Research motivation

The fact that our patient series has the highest number of patients in the English literature makes our study very valuable.

Research objectives

We aimed to discuss this very rare disease, which can be fatal, within the literature information. Because there is no algorithm or general information about its treatment.

Research methods

We have eleven patients in our approximately three-year study, where patient data is complete.

Research results

Three anterior abscesses (27%), two lateral abscesses (18%) in group 1, six abscesses at the base of the tongue (54%) in group 2 were detected.

Research conclusions

Surgical drainage of abscesses larger than one centimeter is inevitable and the clinician should be hurried as soon as the need for a tracheotomy occurs.

Research perspectives

Poor oral hygiene and prevention of odontogenic diseases can prevent this fatal disease.