Clinical observation of pediatric-type follicular lymphomas in adult: Two case reports

Figure 1 Pathological characteristics. A: This pediatric-type follicular lymphoma displayed the "starry sky phenomenon” in case 1, seen on hematoxylin and eosin stain at 100× magnification; B: At 400× magnification in case 2, the follicle is mainly composed of a single medium-sized central cell, with scattered chromatin and inconspicuous nucleoli. The histological grade was by following per under the grade 3 standard of follicular lymphoma; C and D: tumor cells in case 1 expressed CD10 and BCL6 at 100× magnification; E: BCL2 was negative in case 2 at 100× magnification; F: Ki-67 was highly expressed in germinal center (positive index showed 90%) in case 2 at 100× magnification.

Figure 2 Detection of IGH immunoglobulin gene rearrangement. A: This pediatric-type follicular lymphoma displayed IGH immunoglobulin gene rearrangement was positive in case 1; B: IGK immunoglobulin gene rearrangement was positive in case 1.

Figure 3 Detection of gene isolation of BCL2, BCL6 and MYC. A: This pediatric-type follicular lymphoma (PTFL) displayed BCL2 gene isolation were negative in case 1 by fluorescence in situ hybridization (FISH). There were two green signals and two red signals in the cells. Red signals and green signals were close to each other, and some signals overlapped and yellow signals appeared; B: BCL6 gene isolation was negative in case 1 by FISH, there were two green signals and two red signals in the cells. Red signals and green signals were closed to each other; C: This PTFL displayed MYC gene isolation were negative in case 1 by FISH. There were two green signals and two red signals in the cells. Red signals and green signals were close to each other, and some signals overlapped and yellow signals appeared.