Role of international normalized ratio in nonpulmonary sepsis screening: An observational study

Figure 1  Study population.

Figure 2 Receiver operating characteristic curve of white blood cell, neutrophil-lymphocyte count ratio, platelet, prothrombin time, international normalized ratio and quick Sequential “Sepsis-related” Organ Failure Assessment score within 24 h after admission between sepsis and nonsepsis. The results showed that the area under the curve of international normalized ratio (INR), prothrombin time (PT), neutrophil-lymphocyte count ratio (NLCR), platelet (PLT), quick Sequential “Sepsis-related” Organ Failure Assessment (qSOFA), and white blood cell count (WBC) in the diagnosis of sepsis were 0.918, 0.868, 0.83, 0.841, 0.638 and 0.599, respectively, and they were statistically significant (P < 0.05). The study indicates that the INR could be a helpful diagnostic biomarker in sepsis.

Figure 3 Correlation analysis of international normalized ratio value with Sequential “Sepsis-related” Organ Failure Assessment score and Acute Physiology and Chronic Health Evaluation II score, and analysis of international normalized ratio value for predicting the risk of nonpulmonary sepsis. A: Spearman rank correlation analysis between international normalized ratio (INR) value and Sequential “Sepsis-related” Organ Failure Assessment (SOFA) score; B: Spearman rank correlation analysis between INR value and Acute Physiology and Chronic Health Evaluation II (APACHE II) score; C: The positive prediction rate and negative prediction rate of sepsis under different INR values. 95%CI: 95% confidence interval.