Efficacy of artificial liver support system in severe immune-associated hepatitis caused by camrelizumab: A case report and review of the literature

doi:10.12998/wjcc.v9.i17.4415

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jun 16, 2021; 9(17): 4415-4422
Published online Jun 16, 2021. doi: 10.12998/wjcc.v9.i17.4415

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Figure 1 Flow chart of liver function change and treatment intervention. LB: Liver biopsy; MP: Methylprednisolone; DPMAS: Dual plasma molecular adsorption system; PE: Plasma exchange; TBIL: Total bilirubin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; UDCA: Ursodeoxycholic acid; INR: International normalized ratio.

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Figure 2 Pathological findings of liver biopsy. A: Zone 3 and surrounding lobular inflammation (arrow), bile lake (long arrow), and hematoxylin-eosin staining, 200 ×; B: A large number of eosinophils (arrow) and macrophage phagocyte waxy material (long arrow), Periodic Acid-Schiff with diastase, 200 ×; C: CD4⁺ T cells (arrow), CD4⁺T immunohistochemical staining, 200 ×; D: CD8⁺ T cells (arrow), CD8⁺T immunohistochemical staining, 200 ×.

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Figure 3 Double plasma molecular adsorption system.

Citation: Tan YW, Chen L, Zhou XB. Efficacy of artificial liver support system in severe immune-associated hepatitis caused by camrelizumab: A case report and review of the literature. World J Clin Cases 2021; 9(17): 4415-4422
URL: https://www.wjgnet.com/2307-8960/full/v9/i17/4415.htm
DOI: https://dx.doi.org/10.12998/wjcc.v9.i17.4415