Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report

Figure 1 Major medications used in the patient during hospitalization. The dosage of the antibiotics are as follows: Ceftriaxone 2 g/q12h; vancomycin 1000 mg/q12h; biapenem 0.6 g/q12h; linezolid 600 mg/q12h.

Figure 2 Hematological indices of the patient during hospitalization. A: Serum aminotransferase; B: Serum bilirubin; C: Renal function; D: Serum myocardial enzymes; E: Coagulation function; F: Routine blood parameters. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; Scr: Serum creatinine; BUN: Blood urea nitrogen; LDH: Lactate dehydrogenase; CK: Creatine kinase; PT: Prothrombin time; INR: International Normalized Ratio; D-D: D-dimer; FIB: Fibrinogen; Hgb: Hemoglobin; PLT: Platelet; HCT: Hematocrit.

Figure 3 Abdominal computed tomography of the patient during hospitalization. A: On preoperative day 5, the morphology and density of the liver were normal; B: On postoperative day 9, the density of several parts of the liver was low.