Crumbs homolog 2 mutation in two siblings with steroid-resistant nephrotic syndrome: Two case reports

Figure 1 Family pedigree indicating a compound heterozygosity for Crumbs homolog 2 mutations. Parents were unrelated. Genotype is indicated beneath each individual. Mutant alleles are shown in red: c.2290C>T and c.3613G>A.

Figure 2 Whole exon sequencing of Crumbs homolog 2 gene mutations in the two siblings and their parents. The nucleotide exchange is marked by an arrow.

Figure 3  Exons shown in red: Possible steroid-resistant nephrotic syndrome-related hotspot mutation region of Crumbs homolog 2 gene.