Combined immune checkpoint inhibitors of CTLA4 and PD-1 for hepatic melanoma of unknown primary origin: A case report

Figure 1 Tri-phasic, contrast-enhanced abdominal computer tomography. There were heterogeneous masses in the liver with a maximal size of 8.3 cm at segment 4 (arrow). A: Contrast enhancement in the arterial phase; B: Contrast washout in the portal venous phase; C: Contrast washout in the delayed phase.

Figure 2 Pathological results of the lesions. A: Pathological examinations showed epithelioid tumor cells with moderate nuclear atypia, and focal intracytoplasmic melanin pigments in solid nests infiltrating in the liver parenchyma (hematoxylin and eosin, 400 ×); B: Immunohistochemical staining revealed that the tumor cells were HMB45 positive [avidin-biotin complex (ABC), 400 ×]; C: Melan-A positive (ABC, 400 ×); D: SOX10 positive (ABC, 400 ×); E: cytokeratin negative (ABC, 400 ×); F: BRAF V600E positive (ABC, 400 ×).