Cryptococcus infection with asymptomatic diffuse pulmonary disease in an immunocompetent patient: A case report

Figure 1 Positron emission tomography/computed tomography showing bilateral lesions. An elliptic mass without clear margin was shown in the right lower lobe. The size of the mass was 3.46 cm × 2.39 cm. The enlarged right hilar lymph nodes showed a high value of SUVmax. There were also scattered nodules found in both lungs.

Figure 2 Pathological examination revealed Cryptococcus infection. A: Grocott’s methenamine silver staining showed Cryptococcus spores by black staining (arrow); B: Periodic acid-Schiff staining was negative. Original magnification: × 400.

Figure 3 Chest computed tomography scan after 1 mo of antifungal treatment showing resolution of the bilateral lesions. The mass in the right lung was reduced markedly. A: The 25^th floor scan; B: The 26^th floor scan.

Figure 4 Chest computed tomography scan after 3 mo of antifungal treatment showing near complete disappearance of the nodules and infiltration distributed around the lesions. Only a small number of pulmonary cavities remained at this time. A: The 29^th floor scan; B: The 30^th floor scan.