COVID-19: An overview and a clinical update

Figure 1 Pathogenesis. 1: Severe acute respiratory syndrome coronavirus 2 targets the viral structural S protein that binds to the angiotensin-converting enzyme 2 (ACE2) receptor; 2: The host cell, type 2 transmembrane serine protease, promotes viral uptake by cleaving ACE2 and activating the S protein. SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2; ACE2: Angiotensin-converting enzyme 2; TMPRSS2: Type 2 transmembrane serine protease.

Figure 2 Overview of symptomatic, systemic manifestations, and complications of coronavirus disease-2019. ARDS: Acute respiratory distress syndrome; DIC: Disseminated intravascular coagulation.