Extrapontine myelinolysis caused by rapid correction of pituitrin-induced severe hyponatremia: A case report

Figure 1 Serum sodium levels of the patient after admission. The serum sodium gradually declined after the use of pituitrin. Hypertonic saline was administered on day 3 until day 5. Pituitrin therapy was stopped on day 5, then a sharp increase in serum sodium level was detected on day 6, and neurological symptoms appeared on the seventh day after admission.

Figure 2 Brain magnetic resonance imaging during hospitalization. A: Initial brain magnetic resonance imaging (MRI) obtained 3 d after neurological deterioration displayed low signal intensity in the bilateral symmetric basal ganglia (the white arrows) on the axial T1-weighted MRI; B: High signal intensity (the white arrows) on the axial T2-weighted images; C: No lesion in the pons; D-F: Follow-up brain MRI performed one month after treatment. E: Compared to the previous brain MRI, a markedly decreased signal was observed on the T2-weighted image, indicating a significant improvement.