Metastasis of esophageal squamous cell carcinoma to the thyroid gland with widespread nodal involvement: A case report

Figure 1 Right thyroid sonogram. A: Left thyroid sonogram; B: Both A and B show multifocal, hypoechoic, irregular, and calcified nodules in the thyroid gland (orange arrows).

Figure 2 The enhanced contrast neck computed tomography scan shows lesions in the thyroid lobes (white arrows) and enlarged lymph nodes (orange arrows).

Figure 3 Fine needle aspiration cytology of the thyroid lesions stained with hematoxylin and eosin (× 200). A: It shows malignant tumor cells (orange arrows); B: It shows malignant tumor cells (orange arrows).

Figure 4 Fluorine-18-deoxyglucose positron emission tomography-computed tomography fused transaxial images (A-C) and maximum intensity projection (D). A and C: They show the uptake nodal focus (center of crossing); B: It shows an enlarged lymph node (center of crossing) and esophageal lesion (white arrow); D: It shows widespread lymph node involvement (orange arrows) and an esophageal lesion (white arrow).

Figure 5 Fine needle aspiration cytology of the thyroid lesions stained with hematoxylin and eosin (× 200) and the immunohistochemical features. A: Permanent section of the esophagus stained with hematoxylin and eosin shows esophageal squamous cell carcinoma (× 200); B: Histology of MTG stained with hematoxylin and eosin shows multifocal tumor nests (orange arrow) (× 40); C: Immunohistochemical negative staining of metastasis to the thyroid gland (MTG) for thyroid transcription factor-1 (orange arrow) (× 200); D: Immunohistochemical negative staining of MTG for thyroglobulin (orange arrow) (× 200); E: Immunohistochemical positive staining of MTG for CK5/6 (orange arrow) (× 200); F: Immunohistochemical positive staining of MTG for P40 (orange arrow) (× 200); G: Immunohistochemical negative staining of MTG for (orange arrow) (× 200); H: Immunohistochemical negative staining of MTG for paired box gene 8 (orange arrow) (× 200).