Giant benign phyllodes breast tumour with pulmonary nodule mimicking malignancy: A case report

Figure 1 A giant phyllodes tumor of the right breast in a 42-year-old woman: A: Front image; and B: Lateral image.

Figure 2 Preoperative radiologic evaluation. A and B: Chest computed tomography showed a huge mass; C: A pulmonary nodule was seen in the left lung (arrowheads); and D: Preoperative computed tomography showed that there was no clearance between the mass and pectoralis major (arrowheads).

Figure 3 Making use of the superior and inferior skin flaps and even the skin directly overlying the mass which was normal. A: Preoperative photograph of the design to allow skin approximation and closure after removal of the large tumour; and B: Postoperative photograph after tumour resection and skin closed with placement of two drains under the flaps.

Figure 4 The tissue section showing benign phyllodes tumor. A: Cystic components after incision of the tumour; B: (10 ×) Well-circumscribed fibroepithelial neoplasm; C: (40 ×) Prominent leaf-like architecture and areas of hypocellular stroma; D: (400 ×) Bland stromal spindle cells without mitoses or nuclear atypia; E: Ki-67 proliferation index of the tumour was 1 for the stromal component; and F: The P53 index of the stromal component was focally positive.

Figure 5 The tissue section showing lung adenocarcinoma. A: (100 ×) Pathological examination indicated lung adenocarcinoma; B: (400 ×) Tumour cells showed prominent atypia at high magnification; C: (200 ×) Thyroid transcription factor-1 was positive; D: (200 ×) Napsin-A was positive; E: GCDFP-15 was negative; and F: Ki-67 was focally positive.