Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer

Figure 1 ARSB gene expression level is decreased in blood of patients with colorectal cancer, versus control group (left), the low level being a negative prognostic factor (right). CRC: Colorectal cancer.

Figure 2 One third of colorectal cancer specimens (14/45 cases) show triple positivity for ARSA/ARSB/maspin and low circulating ARSB gene expression level (A), as independent negative prognostic factor (B); the overall survival also depends on independently evaluation of protein tissue level of ARSA (C), ARSB (D) and maspin (E).

Figure 3 In colorectal cancer, overall survival rate is not influenced by patients’ age (A) or gender (B) but depends on tumor localization (C) and macroscopic aspect (D).

Figure 4 In colorectal adenocarcinomas, overall survival rate does not depend on grade of differentiation (A) but is strongly influenced by tumor budding degree (B); a slightly correlation is proved with depth of infiltration (C) but lymph node status is not an independent prognostic factor (D, E).