Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet's disease: A case report and review of literature

Figure 1 Computed tomography enterography. Irregular thickening of the intestinal wall was observed in the cecum, ascending colon, transverse colon and descending colon, which also showed skip lesions. The thickest part of the intestinal wall was approximately 16 mm, and the intestinal wall in the arterial enhancement stage showed obvious enhancement (unclear hierarchical boundary); small vessels in the mesangial side were tortuous and dilated (locally formed as a "wooden comb"); and the surrounding fat was slightly blurred. No obvious thickening was observed in the small intestine wall.

Figure 2 Colonoscopy. The mucosa in the ileocecal region, ascending colon, transverse colon and descending colon were scattered with ulcers of varying sizes, all covered with white moss and surrounded by mucosal hyperemia and edema, especially in the ileocecal region:A: Distal ileum; B: Ileocecal region; C: Ascending colon; D: Transverse colon; E: Descending colon; F: Descending colon.

Figure 3 Pathological and immunohistological examination. Immunohistochemistry showed the neoplastic cells were positive for CD2, CD3, CD10, CD30, Ki67, LCA, and Mum-1. The cells were negative for CD20, Bcl-6, Bcl-2, Pax-5, P63, PCK, CD56, P40, ALK-80, and EBER. Pathological examination: A: x 100; B: x 400; Immunohistological examination: C: CD3 (+), x 400; D: CD30 (+), x 400; E: CD56 (-), x 400; F: ALK-80 (-), x 400.