Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease

Figure 1 High sensitivity to food antigens in inflammatory bowel disease patients. A: Positive rate of food-specific IgG antibodies in CD patients, UC patients and HCs. Statistics: Chi-squared test; B: The number of IgG-positive food items in CD patients, UC patients and HCs; C: Comparison of the total serum IgG levels in CD patients, UC patients and HCs. Statistics: ANOVA), ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. UC: Ulcerative colitis; CD: Crohn’s disease; HCs: Healthy controls; ANOVA: One-way analysis of variance.

Figure 2 Distribution of positive IgG to food allergens in CD patients, UC patients and HCs. UC: Ulcerative colitis; CD: Crohn’s disease; HCs: Healthy controls.

Figure 3 The levels of food-specific IgG against 14 common daily foods in CD patients, UC patients and HCs. Statistics: ANOVA, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. UC: Ulcerative colitis; CD: Crohn’s disease; HCs: Healthy controls; ANOVA: One-way analysis of variance.

Figure 4 Association between food-specific IgG antibodies and disease activity. Data are shown as mean ± SD by ANOVA, ^aP < 0.05. ; ANOVA: One-way analysis of variance.

Figure 5 Serum food-specific IgG concentrations in patients treated with different medications and comparison of food-specific IgGs for inflammatory bowel disease patients before and after Infliximab treatment. A: Serum food-specific IgG concentrations in patients treated with different medications. Statistics: ANOVA; B: Comparison of Food-specific IgGs for inflammatory bowel disease patients before and after Infliximab treatment. Statistics: paired-samples t test, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. ANOVA: One-way analysis of variance.

Figure 6 Comparison of total serum IgE levels between CD patients, UC patients and HCs. Statistics: ANOVA. UC: Ulcerative colitis; CD: Crohn’s disease; HCs: Healthy controls; ANOVA: One-way analysis of variance.

Figure 7 Distribution of positive IgE to food allergens in CD patients, UC patients and HCs. UC: Ulcerative colitis; CD: Crohn’s disease; HCs: Healthy controls.