High prevalence of cholestasis, with increased conjugated bile acids in inflammatory bowel diseases patients

Figure 1 Graphic representation of conjugated¹ or not conjugated primary², secondary³ and tertiary⁴ bile acids.

Figure 2 Representation of bile acid subtypes in 3 different situations: Ileal vs colonic disease; inflammatory vs non-inflammatory disease and smokers and non-smokers. TBA: Total bile acids; CA: Cholic acid; CDC: Chenodeoxycholate; DC: Deoxycholate; LCA: Lithocholic acid; UDC: Ursodeoxycholate; TC: Taurocholate; GCA: Gylcocholate acid; TCDC: Taurochenodeoxycholate; GCDC: Glycochenodeoxycholate; TDC: Taurodeoxycholate; GDC: Glycodeoxycholate; TLC: Taurolithocholate; GLC: Glycolithocholate; TUDC: Tauroursodeoxycholate; GUDC: Glycoursodeoxycholate; DHCA: Dihydroxycholestanoic acid; THCA: Trihydroxycholestanoic acid; CA + CDC/DC + LCA: Primary bile acids on secondary bile acids ratio; CA + CDC/TBA: Primary bile acids on TBA ratio; GCA + GCDC/TC + TCDC: Conjugated primary bile acids with glycine on taurine ratio; GDC + GLC/TDC + TLC: Conjugated secondary bile acids with glycine on taurine ratio. ^aP < 0.05; ^bP < 0.01; ^eP < 0.001; ^fP < 0.0001; ^gP < 0.00001.