Unique case of oligoastrocytoma with recurrence and grade progression: Exhibiting differential expression of high mobility group-A1 and human telomerase reverse transcriptase

Figure 1 Radiological scans and findings before each surgical resection. A: MRI scans at initial diagnosis suggestive of glioma; B: CT scans at first recurrence showing calcification indicative of oligo-component presence; C: MRI scans just before third surgical intervention; D: CT scans before last resection confirming increased calcification. MRI: Magnetic resonance imaging; CT: Computed tomography.

Figure 2 Perinuclear halo and honeycomb appearance in oligodendroglial component.

Figure 3 Florescence based immunohistochemistry for analysis and interpretation of human telomerase reverse transcriptase expression. A: Expression of marker in the first resected sample (grade II); B: Signal intensity of the marker at first recurrence (grade II); C: Increased hTERT expression at second recurrence (grade II); D: Intense immune-reactivity at confined foci in last surgical sample resected classified as histopathological grade III. hTERT: Human telomerase reverse transcriptase.

Figure 4 The figure depicts differential high mobility group-A1 immunostaining. A: Minimal immune-expression in initial sample (grade II); B: At first recurrence (grade II); C: Increased signal intensity of the marker in sample from second recurrence (grade II); D: HMGA1 expression highly up-regulated with progression to histopathological grade III. HMGA1: High mobility group-A1.