Cronkhite-Canada syndrome polyps infiltrated with IgG4-positive plasma cells

Figure 1 Systemic skin pigmentation, dystrophic nail changes and alopecia. A: Showing hyperpigmentation in hands and onychodystrophy in fingers; B: Showing hyperpigmentation in feet and onychodystrophy in toes; C: Showing sparse hair.

Figure 2 Endoscopic evaluation revealed multiple sessile polyps in the stomach, small bowel and colon and rectum. A: Electron gastroscopy revealing diffuse polyps in gastric mucosa; B: Capsule endoscopy showing diffuse polyps in small intestinal mucosa; C: Electronic colonoscopy showing diffuse polyps in colorectal mucosa.

Figure 3 Histopathologic examination of biopsies. A: Histopathology examination of gastric polyp showing inflammatory and hyperplasia change (hematoxylin-eosin stain, × 20); B: Histopathology examination of colonic polyp showing inflammatory change (hematoxylin-eosin stain, × 10); C: IgG4 mononuclear cell staining in gastric polyp (× 20); D: IgG4 mononuclear cell staining in gastric polyp (hematoxylin-eosin stain, × 20).