Targeting EGFR and sonic hedgehog pathways for locally advanced eyelid and periocular carcinomas

Figure 1 A 55 year-old man with locally advanced neglected basal cell carcinoma. A-B: The lesion involves the left lateral canthus, upper and lower eyelids, left temple and midface; C: After 29 wk of vismodegib 150 mg daily, there is significant resolution of clinically visible tumor. The only surgical intervention that the patient had undergone at this point was reconstructive surgery to repair the left lower lid cicatricial ectropion via a lateral tarsal strip procedure, a lateral tarsorrhaphy and full-thickness skin graft.