Actinic prurigo of the lip: Two case reports

Figure 1 Case 1. A: Clinical aspect at the first appointment, showing lower lip edema, ulcers and crusts; B: Videoroscopy image showing in detail the presence of ulcer and crust; C: Clinical aspect at the second appointment showing the area of biopsy; D: Clinical aspect one month after treatment, showing remission of the lip edema, ulcers and crusts; E: Histological aspects. Epithelial atrophy and intense diffuse lymphoplasmacytic inflammatory infiltrate extending deep into the fatty tissue (× 10, HE); F: Epithelium showing spongiosis, hydropic degeneration of the basal layer cells and lymphocytic exocytosis. In the connective tissue, lymphocytic inflammatory infiltrate and pigmentary incontinence (arrows) were observed (× 40, HE). G: Secondary lymphoid follicle (× 40, HE); H: Mast cells mainly in the deeper area of the connective tissue (× 20, Giemsa).

Figure 2 Case 2. A: Clinical aspect at the first appointment, showing lower lip edema, dryness and ulcer on the left side of the semimucosa; B: Clinical aspect at the second appointment, showing remission of the ulceration on the left side, and only a small ulcer on the right side of the semimucosa; C: Histological aspects. Lower power view showing epithelial atrophy and ulceration. In the connective tissue, an intense, diffuse inflammatory infiltrate extending deep into the fatty tissue, with some lymphoid follicles was observed (HE); D: Secondary lymphoid follicle (HE).