Correlative factors of poor prognosis and abnormal cellular immune function in patients with Alzheimer’s disease

Figure 1 Flowchart of the study. AD: Alzheimer’s disease.

Figure 2 Magnetic resonance imaging and corresponding magnetic spectroscopy images of an Alzheimer’s disease patient. The patient was a 55-year-old female with a 4-year course of disease and a Mini Mental State Examination Scale score of 14 points. A: Magnetic resonance imaging images (axial view) of the patient showed mild degeneration and atrophy in the hippocampus, deepening of multiple cerebral sulcus, suggesting mild brain atrophy; B: The corresponding magnetic spectroscopy pictures of the patient showed N-acetylaspartate 37mmol/L, creatine 26 mmol/L, and choline 39 mmol/L, indicating that there was a metabolic disorder of brain neurotransmitters.

Figure 3 Lymphocyte subsets in the blood of Alzheimer’s disease patients were detected by flow cytometry. A: T cell was detected by using Anti-human CD3e-PE (ebioscience); B: B cells were detected by using Anti-Human CD19-PerCP (BioLegend); C: Natural killer cells were detected by using anti-human CD56-APC (ebioscience). NK: Natural killer.

Figure 4 Receptor working curve of the predictive value of N-acetylaspartate/creatine ratio of magnetic spectroscopy for poor prognosis of Alzheimer’s disease. ROC: Receptor working curve.