Pembrolizumab combined with axitinib in the treatment of skin metastasis of renal clear cell carcinoma to nasal ala: A case report

Figure 1 Clinical photograph of the lesion at the initial visit and after resumption of target therapy. A: A 2.0 cm × 2.0 cm × 1.2 cm red mass was seen on the right alar of the nose, with soft texture and clear boundary. A small amount of bloody exudate was seen on the surface. The skin vessels around the mass were hyperplastic and dilated; B: Two weeks after the resumption of combined treatment, the mass was reduced to 0.8 cm × 0.8 cm × 0.5 cm, covered with blood scabs, and the hyperplasia and dilation of skin vessels around the mass decreased.

Figure 2 The histopathology of the mass (hematoxylin & eosin staining). Lumplike infiltration of tumor cells was observed in the dermis, some of which formed lumenlike structures with a large number of clear cells and abundant blood vessels.

Figure 3 Immunopathology of the mass. A: S100(-); B: HMB45(-); C: CK7(-); D: AR(-); E: CK5/6(-); F: CAIX(-); G: Vimentin(+); H: EMA(+); I: CD10(+); J: PAX8(+); K: PAX2(+); L: Ki67(+).