Lyophilized recombinant human brain natriuretic peptide: A promising therapy in patients with chronic heart failure

Figure 1 Recombinant human brain natriuretic peptide as a promising therapy in patients with heart failure. Its beneficial effects could be explained by the mechanisms of action of the recombinant human brain natriuretic peptide on the renin-angiotensin-aldosterone system, through the inhibition of norepinephrine and aldosterone secretion, the reduction of the load on cardiomyocytes, the protection of the coronary artery cells, and the inhibition of endothelial cell apoptosis, resulting in reduced inflammatory factor secretion and myocardial damage.