Case Report
Copyright ©The Author(s) 2023.
World J Clin Cases. Dec 26, 2023; 11(36): 8527-8534
Published online Dec 26, 2023. doi: 10.12998/wjcc.v11.i36.8527
Figure 1
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Figure 1 Abdominal computed tomography showed a soft tissue occupying focus in front of the pancreas in Case 1. The lesion had a quasi-round soft tissue density, the edge was smooth, and the enhanced scan showed obvious uniform and continuous enhancement. A: Venous phase; B: Arterial phase; C: Coronal imaging; D: Ultrasonic gastroscopic image.
Figure 2
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Figure 2 A mass of approximately 50 mm × 38 mm × 36 mm can be seen in the pelvic cavity in Case 2. The boundary is clear and the shape is irregular. Small nodular calcification can be seen around the focus, and moderate enhancement was seen on the enhanced scan. A: Arterial phase; B: Venous phase; C: Coronal imaging.
Figure 3
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Figure 3 The density focus of quasi-circular soft tissue below the body of the pancreas in Case 3. The lesion shows obvious enhancement in the arterial phase and a slight decrease in the venous phase and delayed phase, with a diameter of approximately 25 mm, smooth edge, and clear boundary. A: Arterial phase; B: Venous phase; C: Delayed phase; D: Coronal imaging; E: T2W imaging.
Figure 4
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Figure 4 Immunohistochemical diagnosis of hyaline vascular Castleman disease in Case 1. The results were as follows: AE1/AE3 (-), CD10 (-), CD20 (+), CD3 (+), CD45R0 (+), CD79 α (+), LCA (+), Ki-67 (+ 15%), CD5 (+), and Bc1-2 (+). A: HE staining; B: Immunohistochemical staining for CD20; C: Immunohistochemical staining for CD10.
Figure 5
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Figure 5 Pathological diagnosis was hyaline vascular Castleman disease in Case 2. Immunohistochemical results showed CD20 (+), CD3 (+), CD21 (follicular dendritic +), CD23 (follicular dendritic +), CD5 (+), CyclinD1(-), Bcl-2 (germinal center -), Bcl-6 (germinal center +), Ki67 (+, about 40%), CD10 (-), Mul1 (-), Pax-5 (+), CD30 (-), ALK (-), and CD4 (+). A: HE staining; B: Immunohistochemical staining for CD20; C: Immunohistochemical staining for CD10.
Figure 6
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Figure 6 Pathology suggested hyaline vascular Castleman disease in Case 3. The immunohistochemical results were CK20 (+), Pax5 (+), CD3 (+), CD5 (+), CD21 (germinal center +), CD15 (-), CD30 (-), EMA (-), CD10 (germinal center +), Bcl-6 (germinal center +), MuM1 (-), EBER-ISH (-), and Bcl-2 (-). A: HE staining; B: Immunohistochemical staining for CD20; C: Immunohistochemical staining for Bcl-6.