Vericiguat treatment of heart failure: A systematic review and meta-analysis

Figure 1 Flowchart of literature search and selection.

Figure 2 Risk of bias graph of the included studies.

Figure 3 Risk of bias summary of the included studies.

Figure 4 Forest plot of composite endpoint events and heart failure hospitalizations. A: Composite endpoint event (cardiovascular death or first heart failure-related hospitalization); B: Hospitalizations for heart failure.

Figure 5 Forest plot of cardiovascular deaths and all-cause mortality events. A: Cardiovascular death; B: All-cause mortality events.

Figure 6 Forest plot of changes in blood pressure, heart rate, and Kansas Cardiomyopathy Questionnaire physical limitation score. A: Systolic blood pressure; B: Diastolic blood pressure; C: Heart rate; D: Kansas Cardiomyopathy Questionnaire physical limitation score.

Figure 7 Forest plot of adverse events, serious adverse events, symptomatic hypotension, and syncopal events. A: Adverse events; B: Serious adverse events; C: Symptomatic hypotension; D: Syncope.

Figure 8 Forest plot of cardiovascular deaths and all-cause mortality events. A: Cardiovascular deaths; B: All-cause mortality events.

Figure 9 Forest plot of symptomatic hypotension and syncopal events. A: Symptomatic hypotension; B: Syncope.

Figure 10  Funnel plot of cardiovascular deaths, all-cause deaths, symptomatic hypotension, and syncope. A: Cardiovascular deaths; B: All-cause deaths; C: Symptomatic hypotension; D: Syncope.