Observational Study
Copyright ©The Author(s) 2023.
World J Clin Cases. Nov 6, 2023; 11(31): 7593-7609
Published online Nov 6, 2023. doi: 10.12998/wjcc.v11.i31.7593
Figure 1
Open in New Tab Full Size Figure Download Figure
Figure 1 Workflow diagram for assessing the treatment of lung cancer using Liu-Wei-Bu-Qi capsule. LBC: Liu-Wei-Bu-Qi capsule; LC: Lung cancer; TCMSP: Traditional Chinese Medicine Systems Pharmacology; ADME: Absorptio, Distribution, Metabolism, Excretion; DS: Discovery Studio; TTD: Therapeutic Target Database; OMIM: Online mendelian inheritance in man; DAVID: Database for Annotation, Visualization and Integrated Discovery; STRING: Search tool for the retrieval of interacting genes; PPI: Protein-protein interaction.
Figure 2
Open in New Tab Full Size Figure Download Figure
Figure 2 Interaction network diagram of Liu-Wei-Bu-Qi capsule-based treatment of lung cancer. A: The Venn diagram of targets that overlapped between lung cancer-related and active ingredient-related targets; B: The ‘Herbs-Ingredients-Targets’ interaction network. Purple hexagons indicate Chinese herbs, blue squares indicate ingredients; yellow ovals indicate targets. LC: Lung cancer; LBC: Liu-Wei-Bu-Qi capsule; RG: Rou-Gui; SSS: Sheng-Shai-Shen; ZHQ: Zhi-Huang-Qi; YZR: Yi-Zhi-Ren; YZ: Yu-Zhu; CP: Chen-Pi.
Figure 3
Open in New Tab Full Size Figure Download Figure
Figure 3 Protein-Protein Interaction Network. A: All target protein interaction networks; B: Venn diagram based on five parameters; C: The network of hub targets.
Figure 4
Open in New Tab Full Size Figure Download Figure
Figure 4 Gene Ontology enrichment results. A: Key terms of biological processes analysis results; B: Key terms of molecular functions analysis results; C: Key terms of cellular components analysis results. DNA: Deoxyribonucleic acid; RNA: Ribonucleic acid.
Figure 5
Open in New Tab Full Size Figure Download Figure
Figure 5 Kyoto Encyclopedia of Genes and Genomes pathway enrichment diagram.
Figure 6
Open in New Tab Full Size Figure Download Figure
Figure 6 ‘Ingredients-Target-Pathway’ network. A: “Liu-Wei-Bu-Qi capsule-ingredient-target-pathway” network, B: “Key target-ingredient-pathway” network. Purple hexagons indicate a single herb, blue squares indicate ingredients, yellow ovals indicate targets, and red diamonds indicate pathways.
Figure 7
Open in New Tab Full Size Figure Download Figure
Figure 7 Molecular docking simulations of targets and compounds. A: Docking of HIF1A and kaempferol; B: Docking of HIF1A and quercetin; C: Docking of MAPK1 and formononetin; D: Docking of SRC and quercetin; E: Docking of TNF and quercetin; F: Docking of MAPK3 and quercetin; G: Docking of HSP90AA1 and kaempferol; H: Docking of HSP90AA1 and quercetin; I: Docking of ALB and dianthramine; J: Docking of TP53 and protocatechuic acid; K: Docking of ESR1and kaempferol; L: Docking of ESR1 and quercetin.