Fibromatosis-like metaplastic carcinoma of the breast: Two case reports

Figure 1 Right breast mass image of Case 1. A: A mass measuring 4.5 cm × 5.5 cm in diameter was palpable in the right breast 2.5 cm from the nipple at 1 o'clock; B: Postoperative specimen of right breast mass.

Figure 2 Puncture pathology and immunohistochemistry of right breast mass. A: HE staining showed that the tumor was composed of spindle cells with mild morphology and mild atypia of the tumor cells; B: Tumor cells were positive for CKPan by Envision assay; C: Envision test showed that tumor cells were positive for p63; D: Envision test showed tumor cells positive for CK5/6; E: Envision test showed approximately 15% Ki-67 for tumor cells. F: HE stained tumor was composed of spindle cells with mild morphology and mild atypia of tumor cells; G: Tumor cells were positive for CKPan by Envision assay; H: Tumor cells were positive for p63 by Envision assay; I: Tumor cells were partially positive for CK5/6 by Envision assay; J: Ki-67 hotspot area of tumor cells detected by Envision method was about + 25%. Original magnification: × 400; Scale bars: 100 μm.

Figure 3 Imaging data of right breast mass. A: Ultrasonography showed breast imaging reporting and data system (BI-RADS) grade V; B and C: magnetic resonance imaging (MRI) showed breast BI-RADS grade V. D: Ultrasound showed breast BI-RADS grade V; E: MRI showed breast BI-RADS grade V; F: Molybdenum target examination showed breast cancer BI-RADS grade IVb.

Figure 4 Postoperative pathology and immunohistochemistry of right breast cancer. A: HE staining showed that the tumor was composed of spindle cells with mild morphology and mild atypia of the tumor cells; B: Envision test showed tumor cells positive for CKPan; C: Envision test showed tumor cells positive for p63; D: Envision test showed tumor cells positive for CK5/6; E: Envision test showed approximately 20% Ki-67 for tumor cells. F: HE staining showed that the tumor was composed of spindle cells with mild morphology, and the tumor cells were mildly atypical; G: Tumor cells were positive for CKPan by Envision assay; H: Tumor cells were positive for p63 by Envision assay; I: Tumor cells were positive for CK5/6 by Envision assay; J: Ki-67 in tumor cells detected by Envision assay was about 20%. Original magnification: × 400; Scale bars: 100 μm.