Efficacy of EGFR-TKI sequential therapy in patients with EGFR exon 19 insertion-positive non-small-cell lung cancer: A case report

Figure 1 Treatment course of non-small cell lung cancer with sequential epidermal growth factor receptor tyrosine kinase inhibitor regimen with serial chest computed tomography scanning. June 22, 2018, a nodular density shadow in the lower lobe of the right lung, approximately 2.0 cm × 2.7 cm in size, and a ground-glass shadow in the upper right lung lobe, approximately 2 cm × 1.5 cm in size; August 8, 2018, postoperative changes and pleural effusion in the right lung; December 3, 2018, pleural effusion absorbed in the right lung after targeted therapy; June 13, 2019, encapsulated effusion in the right pleural cavity; December 3, 2019, encapsulated effusion increasing in the right pleural cavity. EGFR: Epidermal growth factor receptor; TKI: Tyrosine kinase inhibitor; cfDNA: cell free DNA; NGS: Next-generation sequencing.

Figure 2  Next-generation sequencing showed EGFR exon 19 insertion.