Atrial fibrillation burden and the risk of stroke: A systematic review and dose-response meta-analysis

Figure 1 Flow diagram of the study selection process.

Figure 2 Meta-analysis forest plot: Atrial fibrillation burden and the risk of future stroke. A: Crude risk ratio (RR) model; B: Adjusted RR model; SE: Stand error; CI: Confidence interval.

Figure 3 Trial sequential analysis of atrial fibrillation burden > 5 min. Heterogeneity adjusted required information size of 51978 participants calculated on basis of incidence of 2.37% in control group, relative risk reduction of 30%, α = 5%, β = 20%, and I² = 30%. Actually, accrued number of participants was 37144, 71.5% of required information size. AF: Atrial fibrillation.

Figure 4 Random-effects liner dose-response association between atrial fibrillation burden and the risk future stroke (P_nonlinear = 0. 656). AF: Atrial fibrillation.

Figure 5 Adjusted risk ratio meta-analysis forest plot: Atrial fibrillation burden and the risk of clinical atrial fibrillation. SE: stand error; CI: confidence interval.

Figure 6 Adjusted risk ratio meta-analysis forest plot: Atrial fibrillation burden and the risk of all-cause mortality. SE: Stand error; CI: Confidence interval.