Metastasis to the thyroid gland from primary breast cancer presenting as diffuse goiter: A case report and review of literature

Figure 1 Course of disease. FNAC: Fine-needle aspiration cytology.

Figure 2 Ultrasound images of lymph node and thyroid. A: Contrast-enhanced ultrasound of the left cervical lymph node; B: Fine-needle aspiration cytology of the left lobe of the thyroid.

Figure 3 Hematoxylin-eosin staining and immunohistochemical staining of the left cervical lymph nodes and thyroid. A: Atypical cells from a breast cancer metastatic to the left cervical lymph node processed with histology; B: Nested tumor cells mixed in the thyroid follicles from a breast cancer metastatic to the thyroid gland processed with histology; C: Immunocytochemical evaluation of the Ki-67 index in cervical lymph node metastatic breast carcinoma. The tumor cells are diffusely positive for Ki-67; D: Immunocytochemical evaluation of epithelial membrane antigen (EMA) in thyroid metastatic breast carcinoma. The tumor cells are diffusely positive for EMA.