Tislelizumab-related enteritis successfully treated with adalimumab: A case report

Figure 1 Abdominal contrast-enhanced computed tomography image of the patient at different stages of disease. A: Edema and thickening of the small intestine, ascending colon, transverse colon, sigmoid colon, and rectum in the middle and lower abdomen, and multiple small diverticula in the blind ascending colon; B: The small intestine and colon wall were still obviously edematous, which was similar to the computed tomography findings 10 d ago; C: No significant edema, and there were multiple small diverticula in the ascending colon.

Figure 2 Colonoscopy manifestations of patients at different stages of disease. A and B: Extensive congestion and edema of the terminal ileum and colorectal mucosa, and necrosis and shedding on day 20; C and D: On day 64 showed that the mucosa in the venue was approximately normal, and there was still congestion and swelling of the whole colon and rectal mucosa, which was significantly improved than before.

Figure 3 Pathological sections were examined by colonoscopy. Intestinal mucosal pathological examination revealed chronic inflammation of the mucosa (ileum, ascending colon, and descending colon) with moderate dysplasia of the glandular epithelium, and chronic inflammation of the mucosa (transverse colon and rectum) with moderate-severe dysplasia of the glandular epithelium. A: For the ileocecal junction on day 20; B: For the descending colon on day 20, mucosal epithelial sloughing erosion were not significant compared with the previous colonoscopy, but were still accompanied by moderate atypia and crypt abscess; C: For the ileocecal junction on day 64; D: For the descending colon on day 64.

Figure 4 Treatment of tislelizumab-related enteritis.