Patients with SERPINC1 rs2227589 polymorphism found to have multiple cerebral venous sinus thromboses despite a normal antithrombin level: A case report

Figure 1 Sequence map illustrating the SERPINC1 gene mutation in the patient (A) and his daughter (B). The heterozygous mutation site (rs2227589 polymorphism site) of c.41+141G>A is marked by the black arrow.

Figure 2 Brain magnetic resonance imaging at admission. A: Filling defects seen in the superior sagittal sinus, bilateral transverse sinuses, and sigmoid sinus, indicated by magnetic resonance venography (MRV) are shown by arrows; B: Blurred image of the inferior sagittal sinus and straight sinus, indicated by MRV are shown by arrows; C: Thrombosis of the superior sagittal sinus, indicated by magnetic resonance imaging is shown by the arrow.

Figure 3 Brain magnetic resonance imaging taken 2 wk after treatment. A: Bilateral superior sagittal sinuses, bilateral transverse sinus and sigmoid sinus enlarged with respect to Figure 1, indicated by magnetic resonance venography (MRV) are shown by arrows; B: Inferior sagittal sinus and straight sinus are significantly less occluded with respect to Figure 1, indicated by MRV as shown by the arrow; C: Thrombosis shadow seen in the superior sagittal sinus is reduced in size with respect to Figure 1, indicated by arrow.