Intrathecal methotrexate in combination with systemic chemotherapy in glioblastoma patients with leptomeningeal dissemination: A retrospective analysis

Figure 1 Kaplan-Meier survival curve from leptomeningeal dissemination diagnosis according to treatment. A: Overall survival (OS) of all leptomeningeal dissemination (LMD) patients; B: OS of patients with gross total resection of the tumor or not [median 24.7, 95%CI (15.1, 34.3) vs 10.9, 95%CI (8.0, 13.7), P = 0.022]; C: Difference between KPS > 60 and KPS ≤ 60 (16 mo and 9 mo, respectively, P = 0.002); D: Difference between Ommaya reservoir implant or not (15 mo vs 6 mo, P < 0.001).

Figure 2 Magnetic resonance imaging scans (T1 + gadolinium) of a patient before (upper panel) and after 4 cycles of vp-16 + CBP chemotherapy combination with methotrexate intrathecal injection (lower panel). The lesion in the right temporal lobe was stable after surgery. The multiple lesions in the cervical (middle column, red arrows) and lumbar (right column, red arrows) spine went into remission.