|
1
|
Jankowska L, Adamski Z, Polańska A, Bowszyc-Dmochowska M, Plagens-Rotman K, Merks P, Czarnecka-Operacz M, Żaba R. Challenges in the Diagnosis of Tertiary Syphilis: Case Report with Literature Review. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:16992. [PMID: 36554872 PMCID: PMC9778711 DOI: 10.3390/ijerph192416992] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/08/2022] [Revised: 12/05/2022] [Accepted: 12/07/2022] [Indexed: 06/17/2023]
Abstract
Tertiary syphilis is a large diagnostic challenge. It is rarely the case that it affects the skin, bone tissue and the eyes at the same time. The presented case shows that extensive symptomatology of syphilis poses a challenge in making a proper diagnosis in patients whose history does not suspect STDs. The study aims to present the case of a young woman hospitalized with a suspected autoimmune disease, diagnosed with symptomatic late syphilis with involvement of the skin, bones and eyes.
Collapse
Affiliation(s)
- Lucyna Jankowska
- Department of Dermatology, Heliodor Święcicki Clinical Hospital, Poznan University of Medical Sciences, 60-806 Poznan, Poland
| | - Zygmunt Adamski
- Department of Dermatology, Heliodor Święcicki Clinical Hospital, Poznan University of Medical Sciences, 60-806 Poznan, Poland
| | - Adriana Polańska
- Department of Dermatology and Venenerology, Poznan University of Medical Sciences, 60-806 Poznan, Poland
| | - Monika Bowszyc-Dmochowska
- Department of Dermatology, Heliodor Święcicki Clinical Hospital, Poznan University of Medical Sciences, 60-806 Poznan, Poland
| | - Katarzyna Plagens-Rotman
- Center for Pediatric, Adolescent Gynecology and Sexology Division of Gynecology, Department of Perinatology and Gynecology, Poznan University of Medical Sciences, 61-758 Poznan, Poland
| | - Piotr Merks
- Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warszawa, Poland
| | - Magdalena Czarnecka-Operacz
- Allergic and Occupational Skin Diseases Unit, Department of Dermatology, Medical University of Poznań, 60-355 Poznan, Poland
| | - Ryszard Żaba
- Department of Dermatology and Venenerology, Poznan University of Medical Sciences, 60-806 Poznan, Poland
| |
Collapse
|
|
2
|
Fernandes LPMR, Oliveira CNT, de Brito BB, Freire de Melo F, Souza CL, Oliveira MV. Prevalence and factors associated with non-adherence to therapy among partners of pregnant women with syphilis in a city of northeastern Brazil. World J Obstet Gynecol 2022; 11:20-32. [DOI: 10.5317/wjog.v11.i3.20] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/17/2022] [Revised: 03/30/2022] [Accepted: 06/03/2022] [Indexed: 02/06/2023] Open
Affiliation(s)
| | | | - Breno Bittencourt de Brito
- Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
| | - Fabrício Freire de Melo
- Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
| | - Cláudio Lima Souza
- Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
| | - Márcio Vasconcelos Oliveira
- Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
| |
Collapse
|
|
3
|
Sun DJ, Li HT, Ye Z, Xu BB, Li DZ, Wang W. Gastrointestinal bleeding caused by syphilis: A case report. World J Clin Cases 2021; 9:7909-7916. [PMID: 34621845 PMCID: PMC8462228 DOI: 10.12998/wjcc.v9.i26.7909] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/26/2021] [Revised: 06/15/2021] [Accepted: 07/15/2021] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Syphilis is a chronic, classic sexually transmitted disease caused by Treponema pallidum, which can invade almost all organs of the body and produce various symptoms and signs. Although there are some cases of colorectal bleeding caused by syphilis, small intestinal bleeding caused by syphilis is still rare.
CASE SUMMARY A 58-year-old man had experienced recurrent abdominal pain and melena for 3 years. Repeated gastroenteroscopy and computed tomography angiography examinations failed to find bleeding lesions. During the same admission, multiple intestinal ulcers were found by capsule endoscopy, and syphilis was also diagnosed. With a history of atrial fibrillation and chronic pancreatitis, he had undergone mitral valve replacement and tricuspid valvuloplasty for valvular heart disease. After anti-syphilis treatment, the melena and abdominal pain disappeared and his hemoglobin gradually increased. It is considered that gastrointestinal bleeding, chronic pancreatitis, atrial fibrillation, and heart valvular disease may have been caused by syphilis.
CONCLUSION This case report found that syphilis can mimic systemic disease and cause intestinal bleeding. In addition, treatment of the disease requires both sexual partners to be treated. Finally, although syphilis is easy to treat, it is more important to consider that bleeding could be caused by syphilis.
Collapse
Affiliation(s)
- Dong-Jie Sun
- Department of Digestive Diseases, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China
- Fuzhou General Clinical Medical College, Fujian Medical University, Fuzhou 350025, Fujian Province, China
- Oriental Hospital Affiliated, Xiamen University, Xiamen 350025, Fujian Province, China
| | - Hai-Tao Li
- Department of Digestive Diseases, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China
- Fuzhou General Clinical Medical College, Fujian Medical University, Fuzhou 350025, Fujian Province, China
- Oriental Hospital Affiliated, Xiamen University, Xiamen 350025, Fujian Province, China
| | - Zhou Ye
- Department of Digestive Diseases, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China
- Fuzhou General Clinical Medical College, Fujian Medical University, Fuzhou 350025, Fujian Province, China
- Oriental Hospital Affiliated, Xiamen University, Xiamen 350025, Fujian Province, China
| | - Bin-Bin Xu
- Department of Digestive Diseases, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China
- Fuzhou General Clinical Medical College, Fujian Medical University, Fuzhou 350025, Fujian Province, China
- Oriental Hospital Affiliated, Xiamen University, Xiamen 350025, Fujian Province, China
| | - Da-Zhou Li
- Department of Digestive Diseases, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China
- Fuzhou General Clinical Medical College, Fujian Medical University, Fuzhou 350025, Fujian Province, China
- Oriental Hospital Affiliated, Xiamen University, Xiamen 350025, Fujian Province, China
| | - Wen Wang
- Department of Digestive Diseases, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China
- Fuzhou General Clinical Medical College, Fujian Medical University, Fuzhou 350025, Fujian Province, China
- Oriental Hospital Affiliated, Xiamen University, Xiamen 350025, Fujian Province, China
| |
Collapse
|
|
4
|
Plagens-Rotman K, Jarząbek-Bielecka G, Merks P, Kêdzia W, Czarnecka-Operacz M. Syphilis: then and now. Postepy Dermatol Alergol 2021; 38:550-554. [PMID: 34658692 PMCID: PMC8501445 DOI: 10.5114/ada.2021.108930] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/12/2020] [Accepted: 01/21/2021] [Indexed: 02/07/2023] Open
Abstract
Getting to know the history of syphilis should begin with an attempt to establish the original source of its spread throughout the world. The dispute about the origin of syphilis, a sexually transmitted infection caused by Treponema pallidum (subspecies pallidum), had not been resolved even as late as in the twenty-first century, and to this day the supporters and opponents of the thesis that syphilis was brought to Europe by Christopher Columbus' sailors have been fighting without solid and sustainable foundations. The French named syphilis "the Neapolitan disease", while the Italians called it "the French disease".
Collapse
Affiliation(s)
| | - Grażyna Jarząbek-Bielecka
- Division of Developmental Gynaecology and Sexology, Department of Perinatology and Gynaecology, Poznan University of Medical Sciences, Poznan, Poland
| | - Piotr Merks
- Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszyñski University, Warsaw, Poland
| | - Witold Kêdzia
- Hipolit Cegielski State Higher School of Vocational Education, Gniezno, Poland
| | | |
Collapse
|