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Bollineni S, Malini DL, Mohan TM, Thejashwini VP. Management of a bulbous blunderbuss maxillary central incisor with one root and three canals in a patient with cleft lip and palate. JOURNAL OF CONSERVATIVE DENTISTRY AND ENDODONTICS 2024; 27:668-672. [PMID: 38989486 PMCID: PMC11232772 DOI: 10.4103/jcde.jcde_148_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 03/20/2024] [Revised: 04/11/2024] [Accepted: 05/10/2024] [Indexed: 07/12/2024]
Abstract
Unique anatomical deviations in canal structure are rare in anterior teeth, especially central incisors, and thus risk being overlooked. For successful intervention, a meticulous diagnostic procedure and treatment plan, significantly aided by cone-beam computed tomography (CBCT), are crucial. The case at hand explores the management of a maxillary left central incisor in a cleft palate patient, characterized by multiple developmental lobes, a bulbous crown, and an atypical root anatomy. The primary symptom was pain, accompanied by a history of trauma at age 8 years and ensuing tooth discoloration. Initial evaluations, augmented by CBCT, revealed pulpal necrosis in a single-rooted tooth with three distinct canals. Initial clinical examination was supplemented by electrical pulp testing, RadioVisioGraphy (RVG), and CBCT, after which the root canal therapy was initiated. Informed consent was obtained from the patient. The access cavity preparation resulted in a three-orifice cavity. Subsequently, the canals were enlarged and sufficiently debrided. Calcium-hydroxide was applied for 2 weeks before the commencement of apexification and obturation, followed by esthetic rehabilitation. This case highlights the importance of recognizing rare anatomical variations in anterior teeth and demonstrates the invaluable role of CBCT in both diagnosing and managing such complexities.
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Affiliation(s)
- Swetha Bollineni
- Department of Conservative Dentistry and Endodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India
| | - Duvvuri Lakshmi Malini
- Department of Conservative Dentistry and Endodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India
| | - T. Murali Mohan
- Department of Conservative Dentistry and Endodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India
| | - V. P. Thejashwini
- Department of Conservative Dentistry and Endodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India
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Saele PK, Mustafa M, Åstrøm AN. Orthodontic Status and Association with Oral-Health-Related Quality of Life-A Study of 16-Year-Old Norwegians with a Cleft Lip and Palate. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2024; 21:550. [PMID: 38791765 PMCID: PMC11121370 DOI: 10.3390/ijerph21050550] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/15/2024] [Revised: 04/23/2024] [Accepted: 04/24/2024] [Indexed: 05/26/2024]
Abstract
OBJECTIVE To assess the association between clinical orthodontic indicators and oral-health-related quality of life, adjusted for socio-demographic factors, focusing on 16-year-old patients with cleft lip and/or palate (CL/P). PARTICIPANTS One hundred and twenty-two patients with CL/P, representing cleft-lip (CL), cleft-palate (CP), unilateral/bilateral cleft-lip-palate (UCLP/BCLP), enrolled in the national CLP-Team, Bergen, Norway. METHOD A cross-sectional study by two orthodontists assessing the number of teeth, intermaxillary sagittal relation (ANB-angle), dental arch and occlusion of 16-year-old patients with CL/P. All completed a digital questionnaire including self-reported socio-demographic variables, OHIP-14 questionnaire and dental aesthetics. Cross-tabulations with Pearson's Chi-square test were used to identify associations between self-reported OHRQoL and socio-demographic and clinical indicators. Multiple variable analyses were conducted with binary logistic regression analysis using the odds ratio (OR) and 95% confidence interval (CI) to assess associations between OHRQoL and clinical indicators adjusted for socio-demographic variables. Ethical approval was granted by the regional ethics committee. RESULTS Patients with UCLP and BCLP had poorer clinical indicators compared to patients with CL and CP (p < 0.05). A total of 80% of the patients had OHIP-14 > 0. The highest oral impact was reported for psychological domains and articulation and the least for functional domains. Respondents with BCLP and those with poor intermaxillary relationships (ANB < 0°) reported a high impact on OHRQoL (p < 0.05). No statistically significant associations between other clinical indicators and socio-demographic variables such as gender, educational aspiration, and place of residence were reported. CONCLUSIONS The study revealed an association between severe cleft diagnosis, missing teeth, misaligned teeth, negative overjet, and poor OHRQoL, but a statistically significant association was found only between OHRQoL and poor intermaxillary sagittal relations (unfavorable profile). To improve OHRQoL among patients with clefts, there is a need for an individual follow-up and prioritization of oral healthcare.
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Affiliation(s)
- Paul K. Saele
- Oral Health Centre of Expertise/Western Norway and Department of Clinical Dentistry, University of Bergen, 5009 Bergen, Norway; (M.M.); (A.N.Å.)
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Kaiser JK, Kamble RH, Nambiar K, Nerurkar S, Suchak D. Comprehensive Multidisciplinary Management of Bilateral Cleft Lip and Palate. Cureus 2024; 16:e52643. [PMID: 38380192 PMCID: PMC10876923 DOI: 10.7759/cureus.52643] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/15/2023] [Accepted: 01/20/2024] [Indexed: 02/22/2024] Open
Abstract
Cleft lip and palate (CLP) represent a multifaceted congenital deformity encompassing skeletal, dental, and functional discrepancies. This case report presents the management of a 13-year-old female with bilateral CLP, focusing on the challenges associated with permanent dentition and retained deciduous teeth. The patient's history included prior lip and palate repair surgeries, leading to poor aesthetics and functional concerns. A multidisciplinary approach involving orthodontics, oral surgery, and prosthodontics was implemented. Clinical examinations revealed dental abnormalities, oro-nasal fistula, and skeletal discrepancies, necessitating a comprehensive treatment plan. The orthodontic intervention aimed at aligning the dentition, followed by surgical closure of the oro-nasal fistula and alveolar bone grafting (ABG) to facilitate permanent canine eruption. Prosthetic replacement of missing maxillary lateral incisors was accomplished, enhancing aesthetics with minimal invasiveness. Results demonstrated significant improvements in profile, dental alignment, and functional stability. Cephalometric and dental parameter analyses confirmed the corrections and enhancements achieved, affirming the success of the multidisciplinary treatment. This case report emphasizes the importance of a collaborative multidisciplinary approach in effectively addressing the complexities of bilateral CLP in patients with permanent dentition and retained deciduous teeth. The comprehensive treatment strategy rectified dental and skeletal issues and positively impacted the patient's overall well-being and self-confidence.
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Affiliation(s)
- Japneet K Kaiser
- Orthodontics and Dentofacial Orthopedics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND
| | - Ranjit H Kamble
- Orthodontics and Dentofacial Orthopedics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND
| | - Karthika Nambiar
- Orthodontics and Dentofacial Orthopedics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND
| | - Sumukh Nerurkar
- Orthodontics and Dentofacial Orthopedics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND
| | - Dhwani Suchak
- Orthodontics and Dentofacial Orthopedics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND
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Wang Z, Zhao SY, He WS, Yu F, Shi SJ, Xia XL, Luo XX, Xiao YH. Application of digital positioning guide plates for the surgical extraction of multiple impacted supernumerary teeth: A case report and review of literature. World J Clin Cases 2022; 10:9886-9896. [PMID: 36186207 PMCID: PMC9516922 DOI: 10.12998/wjcc.v10.i27.9886] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/05/2022] [Revised: 06/25/2022] [Accepted: 08/15/2022] [Indexed: 02/05/2023] Open
Abstract
BACKGROUND An extra tooth in the normal tooth sequence in any region of the dental arch is regarded as a supernumerary tooth (SNT). Due to the large variation in location and morphology, the extraction of impacted SNTs is an extensive and complex procedure with high risks of several complications. This report presents a rare case of seven impacted SNTs in the bilateral upper and lower arch that were successfully extracted with the use of digital positioning guide plates.
CASE SUMMARY In January 2022, a 21-year-old male was referred to our department with a chief complaint of pain in relation to tooth #36. Clinical examination showed a deep carious lesion with pulpal involvement in tooth #36 and lingual swelling of the bilateral mandibular posterior area. Radiographic examination revealed seven deeply impacted SNTs in the bilateral posterior area and bilateral impacted mandibular third molars. Based on these findings, the patient was diagnosed with bilateral, multiple impacted SNTs and tooth #36 chronic pulpitis. A root canal treatment and an all-ceramic crown restoration for tooth #36 were performed. An individualized digital positioning guide plate was designed by computer-aided design/computer-aided manufacturing technology and cone-beam computed tomography for extraction of the impacted SNTs. During the operation, the digital positioning guide plate allowed rapid positioning and exposure of the SNTs while avoiding adjacent important anatomical structures. At 3-month follow-up, regeneration of bone and soft tissues was visible.
CONCLUSION The application of digital positioning guide plates is useful for the individualized and minimalized extraction of impacted supernumerary teeth.
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Affiliation(s)
- Zhi Wang
- Department of Oral and Maxillofacial Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
| | - Shu-Yi Zhao
- Department of Oral and Maxillofacial Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
| | - Wu-Shu He
- Department of Oral and Maxillofacial Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
| | - Fan Yu
- Department of Oral and Maxillofacial Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
| | - Shao-Jie Shi
- Department of Oral and Maxillofacial Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
| | - Xue-Ling Xia
- Department of Oral and Maxillofacial Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
| | - Xin-Xiao Luo
- Department of Oral and Maxillofacial Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
| | - Yu-Hong Xiao
- Department of Oral and Maxillofacial Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
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Impact of orthodontic gap closure versus prosthetic replacement of missing maxillary lateral incisor on dental arch relationships and symmetry on 212 cleft patients: a retrospective study Missing lateral incisor gap in cleft patients (39/40 characters max). Plast Reconstr Surg 2022; 150:613e-624e. [PMID: 35791258 DOI: 10.1097/prs.0000000000009477] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
BACKGROUND Maxillary lateral incisors (MLI) are frequently missing in cleft patients. The aim of this study was to assess how orthodontic gap closure or prosthetic rehabilitation of the missing MLI affected the dental arch relationships and symmetry at the end of treatment. We also aimed to determine the impact of the level of oral hygiene on the decision made to manage the missing MLI gap. METHODS A descriptive, retrospective cohort study including all cleft patients born between 1980 and 1999 treated at Nantes Cleft Center was performed. Patients presenting unilateral or bilateral missing MLI were reviewed. Data about management of the missing MLI gap, dental arch relationships, symmetry and level of oral hygiene were collected. RESULTS Four hundred and eighty-six cleft patients were reviewed, including 212 patients with unilateral or bilateral missing MLI. When compared to orthodontic gap closure, prosthetic replacement of the MLI gap was associated with better final dental arch relationships (59.8% vs. 10.3%; p<0.01) and better dental arch symmetry (88.1% vs. 44.0%; p<0.01) for unilateral missing MLI cases but not for bilateral missing MLI cases. A better level of oral hygiene was associated with more cases with prosthetic replacement for unilateral missing MLI cases (p=0.03) and had no impact for bilateral missing MLI cases. CONCLUSION Prosthetic replacement of the missing MLI gap provided better functional and esthetic results for cleft patients presenting with unilateral missing MLI.
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Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis. Clin Oral Investig 2022; 26:5089-5103. [PMID: 35729285 DOI: 10.1007/s00784-022-04540-8] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/05/2021] [Accepted: 05/05/2022] [Indexed: 11/03/2022]
Abstract
OBJECTIVE To evaluate the association between orofacial clefts (OFC) and tooth abnormalities (TA). METHODS We searched PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and BBO, and in the gray literature and selected observational studies that evaluated the association between TA and OFC. The risk of bias was analyzed using the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed comparing the presence and absence of OFC, cleft type-cleft palate (CP) and cleft lip with or without palate (CL/P)-and cleft laterality-unilateral and bilateral. The certainty of evidence was evaluated using the GRADE approach. RESULTS A total of 99 studies were included in the qualitative analysis, and 37 were included in the meta-analysis. Only four studies were classified as low risk of bias. Significant associations were observed between the presence of OFC and tooth agenesis (OR = 19.46; 95%CI = 4.99-75.96), supernumerary teeth (OR = 4.04; 95%CI = 1.26-12.99), developmental defects of enamel (OR = 3.15; 95%CI = 1.28-7.80), microdontia (OR = 15.57; 95%CI = 1.06-228.51), and taurodontism (OR = 1.74; 95%CI = 1.74-2.86). Individuals with CP had a lower frequency of supernumerary teeth (OR = 0.22; 95%CI = 0.08-0.64), peg-shaped tooth (OR = 0.31; 95%CI = 0.12-0.80), and morphological TA (OR = 0.13; 95%CI = 0.04-0.45) than individuals with CL/P. No TA was significantly associated with cleft laterality (p > 0.05). The quality of the evidence was very low in all analyses. CONCLUSION Individuals with OFC had a higher frequency of TA than those without OFC. Individuals with CP had a lower frequency of TA than individuals with CL/P. No TA was associated to cleft laterality. CLINICAL RELEVANCE Help to identify the treatment needs of individuals affected by OFC, improving the services provided to this population.
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Savoldelli C, Bailleux S, Chamorey E, Vandersteen C, Lerhe B, Afota F. Impact of a new combined preoperative cleft assessment on dental implant success in patients with cleft and palate: a retrospective study. BMC Oral Health 2022; 22:73. [PMID: 35291983 PMCID: PMC8925145 DOI: 10.1186/s12903-022-02040-5] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/08/2021] [Accepted: 11/30/2021] [Indexed: 11/17/2022] Open
Abstract
Background Bone height assessment alone is frequently used to guide rehabilitation choice, without consideration for soft tissues or adjacent teeth. This study aimed to evaluate the impact of different preoperative cleft assessments on implant success and patient satisfaction. Methods The study involved a retrospective assessment of records from 40 patients with cleft lip and palate (CLP). The alveolar cleft score (ACS; clinical criteria), interdental alveolar bone height (IABH) score (radiological criteria), patient compliance score (dental hygiene, medical visit observance, and smoking), and a novel combined score (IABH-ACS-Compliance) were assessed from patient records. Patients who required prosthetic tooth rehabilitation in the cleft dental arch space were included. Twenty-six patients (Group 1) were treated with dental implants, and 14 patients (Group 2) selected another prosthetic option (fixed prosthodontics, removal prosthesis), orthodontic space closure, or no rehabilitation. The main outcomes measured were relative implant success (no implant loss involving marginal bone loss ≤ 1.9 mm) for patients treated with dental implant therapy (Group 1) and patient satisfaction for all patients (Groups 1 and 2). Results Forty dental implants were placed in the patients in Group 1. Four implants in four patients (Group 1 relative failure, RF) were lost (implant survival rate of 90%) after 36 (± 12.4) months of follow-up. Twenty-two patients who received implants belonged to the relative implant success group (Group 1 RS). The average “IABH-ACS-Compliance” scores were significantly different (p < 0.05): 16.90 ± 2.35 and 12.75 ± 0.43 for the Group 1 RS and RF groups, respectively. Conclusions Preoperative cleft parameters have an impact on relative implant success and patient satisfaction. The new cleft assessment combined-score (“IABH-ACS-Compliance”) allows an accurate selection of cleft cases eligible for dental implants, thereby improving postoperative outcomes.
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Affiliation(s)
- Charles Savoldelli
- Oral and Maxillo-Facial Surgery Department, Head and Neck Institute, University Hospital of Nice, 30 Avenue Valombrose, 06100, Nice, France. .,Paediatric Maxillofacial Surgery and ENT Department, Lenval Hospital, Nice, France.
| | - Sonanda Bailleux
- Paediatric Maxillofacial Surgery and ENT Department, Lenval Hospital, Nice, France
| | - Emmanuel Chamorey
- Clinical Research, Innovation and Statistics Department, Centre Antoine Lacassagne, Nice, France
| | - Clair Vandersteen
- Oral and Maxillo-Facial Surgery Department, Head and Neck Institute, University Hospital of Nice, 30 Avenue Valombrose, 06100, Nice, France
| | - Barbara Lerhe
- Oral and Maxillo-Facial Surgery Department, Head and Neck Institute, University Hospital of Nice, 30 Avenue Valombrose, 06100, Nice, France.,Paediatric Maxillofacial Surgery and ENT Department, Lenval Hospital, Nice, France
| | - Franck Afota
- Oral and Maxillo-Facial Surgery Department, Head and Neck Institute, University Hospital of Nice, 30 Avenue Valombrose, 06100, Nice, France
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Saele PK, Nordrehaug Aastrøm AK, Gjengedal H, Nasir EF, Mustafa M. Norwegian Orthodontists' Experience and Challenges With Treatment of Patients With Cleft Lip and Palate. Cleft Palate Craniofac J 2021; 59:859-866. [PMID: 34282635 PMCID: PMC9260468 DOI: 10.1177/10556656211028509] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022] Open
Abstract
Background: Patients born with cleft lip and/or palate (CL/P) have orthodontic treatment
challenges due to maxilla deficiency, malocclusions, and dental
abnormalities. In Norway, orthodontic treatment is done by centralized CL/P
teams. Due to traveling restrictions, this treatment might be done locally
in the future. The experience of Norwegian community orthodontists in
managing such patients has not been investigated previously. Objective: To assess Norwegian orthodontists’ management of patients with CL/P and need
for further education. Material and Methods: All orthodontists in Norway were sent a questionnaire about their experience,
challenges, and knowledge and asked about their need of further theoretical
education and clinical training in the management of patients with CL/P. Results: Norwegian orthodontists’ standard of knowledge of CL/P treatment is adequate.
However, few respondents have treated a high number of cleft patients.
Eighty-six percent of the participants believed that treating CL/P patients
involves challenges, such as time-consuming treatment and technical
difficulties. Increased perceived need for more education was revealed among
participants stated unpreparedness during education (4 folds), encountered
challenges, and lack of knowledge (almost 3 folds). Conclusions: The study revealed that community orthodontists in Norway lack experience and
acknowledged the challenges in treating patients with CL/P. Most of the
respondents perceived a need for additional education and clinical training
to treat CL/P patients competently. The findings suggested more focus on
patients with CL/P management in the curricula and more collaboration
between centralized CL/P teams and community orthodontists.
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Affiliation(s)
- Paul K Saele
- Oral Health Centre of Expertise/Western Norway, Department of Clinical Dentistry, University of Bergen, Norway
| | | | | | - Elwalid F Nasir
- King Faisal University SA, University of Science and Technology, Omdurman, Sudan
| | - Manal Mustafa
- Oral Health Centre of Expertise/Western Norway, Bergen, Norway
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Lasota A, Siebieszuk W, Pastuszak P, Mostowska A. The Prevalence and Morphology of Supernumerary Teeth in Children With Nonsyndromic Cleft Lip and Palate. Cleft Palate Craniofac J 2021; 59:867-872. [PMID: 34219486 DOI: 10.1177/10556656211027750] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022] Open
Abstract
INTRODUCTION Cleft lip with or without cleft palate (CL/P) is congenital deformity associated with hyperdontia. OBJECTIVE To determine the prevalence and characteristics of supernumerary teeth in patients with CL/P. DESIGN Retrospective descriptive and correlation clinical study. PATIENTS One hundred thirteen children with cleft (age ranged 9.3-19.2; 67 males and 46 females) treated in Clinic of Congenital Facial Deformities Medical University of Lublin were included in the study. METHODS Records evaluation was conducted regarding age, gender, cleft type (Q36, Q37-International Classification of Diseases 10th revision), cleft side, and incidence of supernumeraries. In all supernumerary teeth, size, shape, and developmental degree were analyzed and correlation between the incidence of hyperdontia with different variables was checked. Correlations were detected using chi-square and the Yates correction. RESULTS The majority of the examined group were males-59.29% with Q37 (67.26%) and the cleft on the left side (62.83%). Hyperdontia was noted in 26.55%. Only upper lateral incisors were affected. They usually had atypical shape (56.67%), reduced size (83.33%), and delayed development (56.67%). CONCLUSIONS The prevalence of supernumerary permanent teeth in patients with cleft was higher than in the general population. Anomaly was more frequent in male patients and occurred mainly on the cleft side. The severity of the cleft did not influenced the frequency of supernumerary teeth, their shape, size, and developmental degree. Supernumerary teeth were characterized by reduced crown size, abnormal structure, incorrect inclination, and delayed development phase.
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Affiliation(s)
- Agnieszka Lasota
- Chair and Department of Jaw Orthopedics, Medical University of Lublin, Poland
| | - Weronika Siebieszuk
- Chair and Department of Jaw Orthopedics, Medical University of Lublin, Poland
| | | | - Adrianna Mostowska
- Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań, Poland
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Möller LH, Pradel W, Gedrange T, Botzenhart UU. Prevalence of hypodontia and supernumerary teeth in a German cleft lip with/without palate population. BMC Oral Health 2021; 21:60. [PMID: 33573652 PMCID: PMC7879655 DOI: 10.1186/s12903-021-01420-7] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/22/2020] [Accepted: 01/27/2021] [Indexed: 11/16/2022] Open
Abstract
Background The distribution of dental abnormalities among cleft patients concerning cleft type frequently poses ambiguity wherefore the aim of this study was to evaluate the prevalence of hypodontia and supernumerary teeth in an exemplary German cleft population dependent on the cleft type. Methods Radiographs and dental records of cleft patients, which had been treated and followed up in the Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus Campus, Dresden, Germany (investigation period of 22 years) were evaluated concerning hypodontia and supernumerary teeth dependent on the cleft type. Out of 386 records, 108 patients met the inclusion criteria: non-syndromic cleft of the alveolus with or without palate (CL/P), at least one clear panoramic x-ray, sufficient dental records. Statistical analysis was performed using x-square and binominal test (p ≤ 0.05). Results Hypodontia was more frequent (54/50%) than supernumerary teeth (36/33.3%) and was more common in bilateral clefts of the lip and palate (BCLP) (70.1%) than in unilateral clefts of the lip and palate (UCLP) (51.6%) or clefts of the lip and alveolus (CLA) (34.5%) (p << 0.001). There was an average of 0.9 missing teeth per patient, thereof the upper lateral incisor was most often affected (23.2%). In contrast, supernumerary teeth were more frequent in CLA (51.7%; p = 0.014) than UCLP (29.0%) and BCLP patients (17.6%). Conclusion The prevalence for numerical dental anomalies was significantly different among the cleft types. Hypodontia significantly increased with the extend of the cleft, whereas the prevalence of supernumerary teeth decreased.
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Affiliation(s)
- Liesa Heidi Möller
- Department of Orthodontics, Carl Gustav Carus Campus TU Dresden, Fetscherstrasse 74, Haus 28, 01307, Dresden, Germany
| | - Winnie Pradel
- Department of Oral and Maxillofacial Surgery, Dresden University Hospital, Fetscherstrasse 74, 01307, Dresden, Germany
| | - Tomasz Gedrange
- Department of Orthodontics, Carl Gustav Carus Campus TU Dresden, Fetscherstrasse 74, Haus 28, 01307, Dresden, Germany
| | - Ute Ulrike Botzenhart
- Department of Orthodontics, Carl Gustav Carus Campus TU Dresden, Fetscherstrasse 74, Haus 28, 01307, Dresden, Germany.
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Pradhan L, Shakya P, Thapa S, Nakarmi KK, Maharjan A, Sagtani RA, Rai SM. Prevalence of Dental Anomalies in the Patient with Cleft Lip and Palate Visiting a Tertiary Care Hospital. ACTA ACUST UNITED AC 2020; 58:591-596. [PMID: 32968294 PMCID: PMC7580371 DOI: 10.31729/jnma.5149] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/01/2022]
Abstract
INTRODUCTION Dental anomaly is one of the major problems in a child born with cleft lip and palate. These anomalies have deleterious effects on the dentition leading to aesthetic problems, impairment of mastication andimproper phonation. The aim of our study was to find out the prevalence of dental anomalies in patient with cleft lip and/or palate radiographically. METHODS A descriptive cross-sectional study was conducted from the 208 radiographs, collected by the convenience samplingtechnique with cleft lip and/or palate in Department of Burns, Plastic and Reconstructive Surgery, Nepal Cleft and Burn Centre, Kirtipur Hospital from January 2017 to July 2019.Ethical clearance for the study was obtained from Institutional Review Committee. Demographic data were collected and radiographs were evaluated for possible dental anomalies. Data obtained were entered and analysed in Statistical Package for Social Sciences version 23. RESULTS Dental anomalies were highly prevalent among cleft lip and palate patients with at least one anomaly present in 188 (90.4%) of patients with male 120 (57.4%) presenting more anomalies than female 88 (42.6%) population. The most common anomaly was dental agenesis 161 (77.9%). The prevalence of positional anomaly, morphological anomaly and supernumerary teeth were found to be 54 (26%), 33 (15.9%) and 20 (10%) respectively. Lateral incisor showed the highest incidence of agenesis among all other missing teeth 223 (65.2%). CONCLUSIONS The prevalence of dental anomalies among patients with cleft lip and/or palate was found to be high. Tooth agenesis was the most common anomaly observed in the study with lateral incisor having the highest incidence of agenesis.
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Affiliation(s)
- Leeza Pradhan
- Department of Burns, Plastic and Reconstructive Surgery, Nepal Cleft and Burn Centre, Kirtipur Hospital, Kathmandu, Nepal
| | - Pramila Shakya
- Department of Burns, Plastic and Reconstructive Surgery, Nepal Cleft and Burn Centre, Kirtipur Hospital, Kathmandu, Nepal
| | - Swosti Thapa
- Department of Burns, Plastic and Reconstructive Surgery, Nepal Cleft and Burn Centre, Kirtipur Hospital, Kathmandu, Nepal
| | - Kiran Kishor Nakarmi
- Department of Burns, Plastic and Reconstructive Surgery, Nepal Cleft and Burn Centre, Kirtipur Hospital, Kathmandu, Nepal
| | - Anjana Maharjan
- Department of Dentistry, Patan Academy of Health Sciences, Lalitpur, Nepal
| | | | - Shankar Man Rai
- Department of Burns, Plastic and Reconstructive Surgery, Nepal Cleft and Burn Centre, Kirtipur Hospital, Kathmandu, Nepal
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Yezioro-Rubinsky S, Eslava-Schmalbach JH, Otero L, Rodríguez-Aguirre SA, Duque ÁM, Campos FM, Gómez JP, Gómez-Arango S, Posso-Moreno SL, Rojas NE, Garzón-Orjuela N. Dental Anomalies in Permanent Teeth Associated With Nonsyndromic Cleft Lip and Palate in a Group of Colombian Children. Cleft Palate Craniofac J 2019; 57:73-79. [DOI: 10.1177/1055665619861498] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022] Open
Abstract
Objectives: To assess the risk of dental anomaly presentation in permanent teeth in a group of Colombian children with nonsyndromic cleft lip and palate (NSCLP) and to determine the frequency of the anomalies according to the cleft type. Methods: An analytical matched case–control study was conducted with 210 controls and 210 patients with NSCLP. The patients were classified into 3 groups: complete right unilateral cleft lip and palate (RCLP), complete left unilateral cleft lip and palate (LCLP), and complete bilateral cleft lip and palate (BCLP). Univariate and multivariate Poisson regression models were used to analyze paired samples (Bonferroni adjustment, P ≤ .002). Results: A high risk of finding agenesis of the maxillary lateral incisors, supernumerary teeth, microdontia of the maxillary lateral incisors, and rotation of the maxillary central incisors adjacent to the cleft ( P < .0001) was observed in the patients with NSCLP. One or more dental anomalies were found in 98% of patients with BCLP, in 96% of those with LCLP, and in 87% of those with RCLP. Most of the anomalies were located on the cleft area. The incidence relative risk (IRR) of anomalies was highest in patients with BCLP (IRR: 10.5; 95% confidence interval [CI]: 6.76-16.3), followed by in those with LCLP (IRR: 8.51; 95% CI: 5.64-12.8). Conclusions: Most dental anomalies were found in the cleft area; this was expected because the cleft area was the most affected in the patients included in this study.
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Affiliation(s)
| | - Javier H. Eslava-Schmalbach
- Hospital Universitario Nacional de Colombia. School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia
| | - Liliana Otero
- Faculty of Dentistry, Pontificia Universidad Javeriana, Bogotá, Colombia
| | | | | | - Flora M. Campos
- Faculty of Dentistry, Universidad Cooperativa de Colombia and Universidad Antonio Nariño, Bogotá, Colombia
| | - Juan P. Gómez
- Faculty of Dentistry, Universidad Autónoma de Manizales, Manizales, Colombia
| | | | | | | | - Nathaly Garzón-Orjuela
- Hospital Universitario Nacional de Colombia. School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia
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Joybell C, Krishnan R, Kumar S. Evaluation of Postsurgical Dentofacial Deformities in Children Operated for Correction of Cleft Lip and Palate-A Cross-sectional Study. Int J Clin Pediatr Dent 2019; 12:165-177. [PMID: 31708610 PMCID: PMC6811945 DOI: 10.5005/jp-journals-10005-1613] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/23/2022] Open
Abstract
AIM The aim of this study is to evaluate the various dentofacial deformities in children who were surgically managed for cleft lip and palate (CLP). MATERIALS AND METHODS The study was carried out in 100 surgically managed cleft lip palate children between the ages of 4 years and 15 years. After eliciting a detailed history, a thorough intraoral and extraoral examination was done and details were recorded in a printed proforma with photographs. DESIGN Cross-sectional study. STATISTICAL ANALYSIS USED All the data were analyzed using SPSS 11.5 software for evaluation using the Chi-square test. RESULTS A wide range of surgical, dental, and functional problems among the surgically managed CLP patients were seen. CONCLUSION The timing of direct lip repair showed a significant influence on the severity of dentofacial deformities. Lip repair before the age of 1 increases the severity of the deformity. HOW TO CITE THIS ARTICLE Joybell C, Krishnan R, et al. Evaluation of Postsurgical Dentofacial Deformities in Children Operated for Correction of Cleft Lip and Palate-A Cross-sectional Study. Int J Clin Pediatr Dent 2019;12(3):165-177.
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Affiliation(s)
- Chrishantha Joybell
- Department of Pedodontics and Preventive Dentistry, SRM Kattankulathur Dental College, Chennai, Tamil Nadu, India
| | - Ramesh Krishnan
- Department of Pedodontics and Preventive Dentistry, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India
| | - Suresh Kumar
- Department of Pedodontics, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India
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SERRA AVP, CARVALHO MMMD, ANDRADE MGD, AZEVEDO RAD, SARDINHA SDCS. Avaliação clínica e radiográfica de implantes dentários em área de fissura alveolar. REVISTA DE ODONTOLOGIA DA UNESP 2018. [DOI: 10.1590/1807-2577.03818] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
Resumo Introdução As fissuras labiopalatinas são más formações que causam importantes impactos não só estéticos, auditivos e fonéticos, mas também na integração social de seu portador. Objetivo Avaliar os aspectos clínicos e radiográficos de implantes osteointegráveis, em região de fissuras labiopalatinas, instalados em um centro de referência em Salvador, Bahia. Material e método Foi realizado um estudo observacional, no qual foram incluídos todos os pacientes que realizaram implantes dentários osteointegrados em área de fissura alveolar, no período de setembro de 2014 a outubro de 2016. Após análise de prontuários, observaram-se implantes que obtiveram estabilidade secundária, constatada através do travamento bidigital, no momento da instalação dos cicatrizadores; a reconstrução prévia com enxerto de crista ilíaca; a importância do tipo de fissura no resultado do implante; os enxertos complementares realizados em ambiente ambulatorial, bem como a correlação destes fatores com o índice de sucesso dos implantes instalados nessa unidade. Resultado Foram instalados 15 implantes em 10 pacientes com diferentes tipos de fissura. A taxa de sucesso clínico foi de 80% dos implantes, e, radiograficamente, em apenas um caso houve suspeita de falha na neoformação óssea. Conclusão Os implantes instalados em região de fissura nos pacientes do centro de referência em Salvador-Bahia, apresentaram clinicamente estabilidade secundária e neoformação óssea sugestiva, clínica e radiograficamente, em níveis semelhantes aos descritos na literatura.
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Sæle P, Østhus E, Ådalen S, Nasir EF, Mustafa M. Pattern of clefts and dental anomalies in six-year-old children: a retrospective observational study in western Norway. Acta Odontol Scand 2017; 75:100-105. [PMID: 27897086 DOI: 10.1080/00016357.2016.1260770] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/20/2022]
Abstract
OBJECTIVES Clefts of the lip and/or palate (CL/P) are the most common congenital disorders of the head and neck. In Norway, the incidence is 1.9/1000 live births. The aim of this study was to investigate the frequency and distribution of various types of clefts and dental anomalies in patients treated by the cleft lip and palate (CLP) team in Bergen, Norway. MATERIAL AND METHODS The material comprised the records of patients 6 years of age, examined by the CLP team in Bergen from spring 1993 to autumn 2012, incomplete records were excluded. The records of 989 patients were analysed, using frequencies and Chi-square test to compare differences in percentages between groups. RESULTS The gender distribution was 58.8% male and 41.2% female. Isolated cleft palate (CP) was the most common condition (39.5%). Clefts of the lip, jaw and palate (CLP) constituted (30%) of cases and (30.5%) had isolated cleft lip (CL). The frequencies of agenesis, supernumerary and peg-shaped teeth were (36.5%), (17.8%) and (7.5%), respectively. Over 50% of the study population were diagnosed with one or more malocclusion. Of the CLP patients, 61.4% had Angle Class III occlusion. Statistical analysis disclosed a positive association of agenesis with Class III occlusion (OR =1.8, p≤ 0.001). CONCLUSIONS The findings supported the hypothesis that the distribution of dental anomalies and occlusal disorders varied among patients with CL, CP and CLP. In patients with cleft, there is a twofold chance to get Class III malocclusion in the presence of agenesis.
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Affiliation(s)
- Paul Sæle
- Oral Health Centre of Expertise, Western Norway, Bergen, Norway
| | - Eirik Østhus
- Department of Clinical Dentistry, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway
| | - Sondre Ådalen
- Department of Clinical Dentistry, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway
| | - Elwalid F. Nasir
- Oral Health Centre of Expertise, Western Norway, Bergen, Norway
- Department of Clinical Dentistry, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway
- University of Science and Technology, Omdurman, Sudan
| | - Manal Mustafa
- Oral Health Centre of Expertise, Western Norway, Bergen, Norway
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Berniczei-Roykó Á, Tappe JH, Krinner A, Gredes T, Végh A, Gábor K, Linkowska-Świdzińska K, Botzenhart UU. Radiographic Study of the Prevalence and Distribution of Hypodontia Associated with Unilateral and Bilateral Clef Lip and Palate in a Hungarian Population. Med Sci Monit 2016; 22:3868-3885. [PMID: 27767023 PMCID: PMC5077290 DOI: 10.12659/msm.897957] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
Background Cleft defects are one of the most frequent birth-deformities of the orofacial region and they are commonly associated with anomalies of the tooth structure, size, shape, formation, eruption, and tooth number. The aim of our study was to evaluate the prevalence, distribution, and potential association of combined hypodontia in cleft-affected patients with regard to all types of teeth in both jaws in the permanent dentition. Material/Methods This retrospective radiographic analysis included patients with various types of clefts treated orthodontically in the Department of Orofacial Orthopedics and Orthodontics at Heim Pàl Children’s Hospital, Budapest. There were 150 patients (84 males, 66 females) with non-syndromic unilateral (UCLP; n=120 patients) or bilateral (BCLP; n=30 patients) cleft formation (lip, alveolus and palate) who met the inclusion criteria. Statistical analysis was performed using the chi-square test and Fisher’s exact test (significance level p<0.05). Results Hypodontia was significantly more frequent in patients with cleft-sided lateral incisor (104 patients, 69%), with a total of 235 missing teeth, followed by the second premolars of the upper and lower jaw. A significant correlation of congenital missing teeth was observed in left-sided clefts between the upper and lower second premolar in the cleft area. Conclusions Hypodontia inside and outside the cleft area was frequently observed. This should affect the therapy plans, especially if the cleft-sided premolar is also absent. Further comprehensive research including numerous random samples is necessary for better estimating other possible associations.
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Affiliation(s)
- Ádám Berniczei-Roykó
- Department of Orthodontics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany
| | - Jan-Hendrik Tappe
- Department of Orthodontics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany
| | - Axel Krinner
- Institute for Medical Informatics and Biometry (IMB), Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany
| | - Tomasz Gredes
- Department of Orthodontics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany
| | - András Végh
- Department of Orofacial Orthopedics and Orthodontics, Heim Pàl Children's Hospital, Budapest, Hungary
| | - Katona Gábor
- Department of Oto-Rhino-Laryngology and Bronchology, Heim Pàl Children's Hospital, Budapest, Hungary
| | | | - Ute Ulrike Botzenhart
- Department of Orthodontics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany
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Rengifo Reina HA. Dental characterization of colombian children with non syndromic cleft lip and palate. ACTA ACUST UNITED AC 2016. [DOI: 10.1016/j.rodmex.2016.08.014] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/30/2022]
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Suzuki A, Nakano M, Yoshizaki K, Yasunaga A, Haruyama N, Takahashi I. A Longitudinal Study of the Presence of Dental Anomalies in the Primary and Permanent Dentitions of Cleft Lip and/or Palate Patients. Cleft Palate Craniofac J 2016; 54:309-320. [PMID: 27031269 DOI: 10.1597/15-186] [Citation(s) in RCA: 21] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
OBJECTIVE The aim is to survey primary and permanent dental anomalies: hypodontia, microdontia, a supernumerary tooth, and fused teeth in patients with cleft lip and/or palate. DESIGN Retrospective longitudinal study Subjects : The subjects were selected from all 1724 patients with cleft lip and/or palate who were registered at the orthodontic clinic of Kyushu University Hospital, Fukuoka, Japan, from 1970 to 2009. Finally, 994 subjects were evaluated for primary dentition, 1352 for permanent dentition, and 871 for the longitudinal changes from primary to permanent dentition. METHODS The prevalence of dental anomalies was compared for each tooth type, among various cleft types, between males and females, and between the alveolar cleft area and the noncleft area. RESULTS The prevalence of hypodontia was 16.2% for primary dentition and 52.7% for permanent dentition in the subjects with cleft lip and/or palate. Hypodontia increased with the severity of the cleft type. Multiple hypodontia was found more frequently in the subjects with bilateral cleft lip and palate and the subjects with unilateral cleft lip and palate. Microformed lateral incisors were found in 22.7% of permanent lateral incisors but not in primary dentition. Supernumerary teeth were found in 17.7% of the subjects with cleft lip and/or palate for primary maxillary dentition and in 5.7% for permanent maxillary dentition. CONCLUSION The prevalence of hypodontia was greater in permanent dentition than in primary dentition; although, it was not much different between males and females or between the right and left sides. The prevalence of dental anomalies was significantly different among four groups by cleft type: cleft lip, cleft lip and alveolus, cleft lip and palate, and cleft palate.
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Sá J, Araújo L, Guimarães L, Maranhão S, Lopes G, Medrado A, Coletta R, Reis S. Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate. Med Oral Patol Oral Cir Bucal 2016; 21:e48-52. [PMID: 26615505 PMCID: PMC4765753 DOI: 10.4317/medoral.20757] [Citation(s) in RCA: 16] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/05/2015] [Accepted: 08/05/2015] [Indexed: 11/05/2022] Open
Abstract
BACKGROUND Individuals with nonsyndromic cleft lip with or without cleft palate (NSCL±P) present high frequency of dental anomalies, which may represent complicating factors for dental treatment. The aim of this study was to investigate the prevalence of dental anomalies inside cleft area in a group of Brazilians with NSCL±P. MATERIAL AND METHODS Retrospective analysis of 178 panoramic radiographs of patients aged from 12 to 45 years old and without history of tooth extraction or orthodontic treatment was performed. Association between cleft type and the prevalence of dental anomalies was assessed by chi-square test with a significance level set at p≤ 0.05. RESULTS Dental anomalies were found in 88.2% (n=157) of the patients. Tooth agenesis (47.1%), giroversion (20%) and microdontia (15.5%) were the most common anomalies. Individuals with unilateral complete cleft lip and palate (CLP, p<0.0001), bilateral complete CLP (p=0.0002) and bilateral incomplete CLP (p< 0.0001) were more affected by tooth agenesis than individuals with other cleft types. The maxillary lateral incisors were the most affected teeth (p<0.0001). CONCLUSIONS The present study revealed a high frequency of dental anomalies inside cleft region in NSCL±P patients, and further demonstrated that patients with unilateral complete CLP and bilateral incomplete CLP were frequently more affected by dental anomalies. Moreover, our results demonstrate that dental anomalies should be considered during dental treatment planning of individuals affected by NSCL±P.
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Affiliation(s)
- Jamile Sá
- Department of Basic Science, Bahiana School of Medicine and Public Health, Av. Silveira Martins, no 3386, Cabula, CEP: 41150-100, Salvador, Bahia, Brazil,
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Al-Kharboush GH, Al-Balkhi KM, Al-Moammar K. The prevalence of specific dental anomalies in a group of Saudi cleft lip and palate patients. Saudi Dent J 2015; 27:75-80. [PMID: 26082573 PMCID: PMC4459076 DOI: 10.1016/j.sdentj.2014.11.007] [Citation(s) in RCA: 18] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2014] [Revised: 10/01/2014] [Accepted: 11/04/2014] [Indexed: 11/25/2022] Open
Abstract
Objective The aims of this study were to investigate the prevalence and distribution of dental anomalies in a group of Saudi subjects with cleft lip and palate (CLP), to examine potential sex-based associations of these anomalies, and to compare dental anomalies in Saudi subjects with CLP with published data from other population groups. Design This retrospective study involved the examination of pre-treatment records obtained from three CLP centers in Riyadh, Saudi Arabia, in February and March 2010. The pre-treatment records of 184 subjects with cleft lip and palate were identified and included in this study. Pre-treatment maxillary occlusal radiographs of the cleft region, panoramic radiographs, and orthodontic study models of subjects with CLP were analyzed for dental anomalies. Results Orthopantomographs and occlusal radiographs may not be reliable for the accurate evaluation of root malformation anomalies. A total of 265 dental anomalies were observed in the 184 study subjects. Hypodontia was observed most commonly (66.8%), followed by microdontia (45.6%), intra-oral ectopic eruption (12.5%), supernumerary teeth (12.5%), intra-nasal ectopic eruption (3.2), and macrodontia (3.2%). No gender difference in the prevalence of these anomalies was observed. Conclusions Dental anomalies were common in Saudi subjects with CLP type. This will complicate the health care required for the CL/P subjects. This study was conducted to epidemiologically explore the prevalence of dental anomalies among Saudi Arabian subjects with CLP.
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Lateral Incisor Agenesis Predicts Maxillary Hypoplasia and Le Fort I Advancement Surgery in Cleft Patients. Plast Reconstr Surg 2015; 135:142e-148e. [DOI: 10.1097/prs.0000000000000779] [Citation(s) in RCA: 15] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/24/2022]
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Ata-Ali F, Ata-Ali J, Peñarrocha-Oltra D, Peñarrocha-Diago M. Prevalence, etiology, diagnosis, treatment and complications of supernumerary teeth. J Clin Exp Dent 2014; 6:e414-8. [PMID: 25593666 PMCID: PMC4282911 DOI: 10.4317/jced.51499] [Citation(s) in RCA: 55] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2014] [Accepted: 05/01/2014] [Indexed: 12/20/2022] Open
Abstract
The aim of this article was to review the literature on supernumerary teeth, analyzing their prevalence, etiology, diagnosis, treatment and possible complications. An electronic search was made in the Pubmed-Medline database up to January 2014 using the key search terms “multiple supernumerary teeth” (n=279), “prevalence supernumerary teeth” (n=361), and “supernumerary teeth” (n=2412). In addition to the articles initially identified, others were included in the review proceeding from a manual search and from any references considered of relevance.
Supernumerary teeth are those that exceed the normal dental formula. They are more common in men, more common in the upper maxilla, and more prevalent in permanent dentition. Complications associated with supernumerary teeth include dental impaction, delayed eruption, ectopic eruption, overcrowding, spacing anomalies and the formation of follicular cysts. The treatment of supernumerary teeth depends on their type, position, and possible complications, detected clinically and radiographically. No clear consensus exists as to the best time to extract unerupted supernumerary teeth.
Key words:Hyperdoncia, supernumerary teeth, impacted teeth, treatment, permanent teeth, deciduous teeth.
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Affiliation(s)
- Fadi Ata-Ali
- DDS, MS. Valencia University Medical and Dental School
| | - Javier Ata-Ali
- DDS, MS, MPH, PhD. Public Dental Health Service. Arnau de Vilanova Hospital. Master in Oral Surgery and Medicine. Master in Oral Surgery and Implantology. Collaborating professor of the Master in Oral Surgery and Implantology. Valencia University Medical and Dental School
| | - David Peñarrocha-Oltra
- DDS, MS, PhD. Master in Oral Surgery and Implantology. Collaborating professor of the Master in Oral Surgery and Implantology. Valencia University Medical and Dental School
| | - Miguel Peñarrocha-Diago
- DDS, PhD, MD. Professor, Director of the Master of Oral Surgery and Implantology. Valencia University Medical and Dental School, Valencia, Spain
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Akcam MO, Aydemir H, Özer L, Özel B, Toygar-Memikoğlu TU. Three-dimensional tooth crown size symmetry in cleft lip and cleft palate. Angle Orthod 2014; 84:623-627. [PMID: 24423204 PMCID: PMC8650445 DOI: 10.2319/072013-526.1] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/01/2013] [Accepted: 11/01/2013] [Indexed: 07/21/2023] Open
Abstract
OBJECTIVE To evaluate and compare three-dimensional tooth size symmetry in the right and left sides of upper and lower dental arches in cleft lip and palate (CLP) patients and to compare it with an Angle Class I normal occlusion control group. MATERIALS AND METHODS Dental casts of 72 individuals with CLP (20 bilateral [BCLP], 34 unilateral left [ULCLP], and 18 unilateral right [URCLP]) and 53 individuals with Class I occlusion, all with permanent dentition, were randomly selected. Mesiodistal (MD), labiolingual (LL), and occlusogingival (OG) measurements of upper and lower teeth were recorded with a digital caliper. Descriptive statistics and paired t-test were used for statistical analysis. RESULTS Significant asymmetries were found between the right and left sides of the dental arches in CLP as follows: MD dimension: mandibular first premolar (ULCLP, P < .01); LL dimension: mandibular first premolar (URCLP, P < .05); OG dimension: maxillary central incisor and first premolar (ULCLP, P < .05 and P < .01, respectively), central incisor (BLCLP, P < .01), mandibular canine and first premolar (ULCLP, P < .01), and first molar (ULCLP, P < .05). Tooth crown size asymmetries were also recorded in the Class I group. CONCLUSIONS Significant three-dimensional tooth size asymmetries were found in CLP subjects; however, such asymmetries were also present on the Class I control group.
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Affiliation(s)
- M. Okan Akcam
- Professor, Department of Orthodontics, Faculty of Dentistry, University of Ankara, Ankara, Turkey
| | - Halise Aydemir
- Assistant Professor, Orthodontist, Turgut Özal University Oral and Dental Health Care Center, Ankara, Turkey
| | - Levent Özer
- Professor, Department of Pediatric Dentistry, Faculty of Dentistry, University of Ankara, Ankara, Turkey
| | - Berna Özel
- Private Practice, Orthodontist, Trabzon, Turkey
| | - T. Ufuk Toygar-Memikoğlu
- Professor, Department of Orthodontics, Faculty of Dentistry, University of Ankara, Ankara, Turkey
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Germec-Cakan D, Canter HI, Cakan U, Demir B. Interdisciplinary treatment of a patient with bilateral cleft lip and palate and congenitally missing and transposed teeth. Am J Orthod Dentofacial Orthop 2014; 145:381-92. [PMID: 24582029 DOI: 10.1016/j.ajodo.2013.06.021] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/01/2013] [Revised: 06/01/2013] [Accepted: 06/01/2013] [Indexed: 11/19/2022]
Abstract
The comprehensive treatment of a patient with cleft lip and palate requires an interdisciplinary approach for functional and esthetic outcomes. A 20-year-old woman with bilateral cleft lip and palate had a chief complaint of unesthetic appearance of her teeth and the presence of oronasal fistulae. Her clinical and radiographic evaluation showed a dolichofacial growth pattern, a Class II skeletal relationship with retroclined maxillary central incisors, 5 mm of negative overjet, maxillary constriction, maxillary and mandibular crowding, congenitally missing maxillary right incisors and left lateral incisor, and a transposed maxillary left canine. Her treatment plan included the extraction of 3 premolars, maxillary expansion, segmental maxillary osteotomy, repair of the oronasal fistulae, rhinoplasty, periodontal surgery, and prosthodontic rehabilitation. To obtain a better occlusion and reduce the dimensions of the fistulae, orthognathic surgery comprising linear and rotational movements of the maxillary segments (premaxilla, right and left maxillary alveolar segments) in all 3 axes was planned by performing 3-dimensional virtual surgery on 3-dimensional computerized tomography. At the end of the interdisciplinary treatment, a functional occlusion, a harmonious profile, and patient satisfaction were achieved. Posttreatment records after 1 year showed stable results.
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Affiliation(s)
- Derya Germec-Cakan
- Associate professor, Department of Orthodontics, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey.
| | - Halil Ibrahim Canter
- Associate professor, Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Acibadem University, Istanbul, Turkey
| | - Umut Cakan
- Assistant professor, Department of Prosthodontics, Faculty of Dentistry, Istanbul Medipol University, Istanbul, Turkey
| | - Becen Demir
- Periodontist in private practice, Istanbul, Turkey
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Mikulewicz M, Ogiński T, Gedrange T, Berniczei-Royko A, Prussak E. Prevalence of second premolar hypodontia in the Polish cleft lip and palate population. Med Sci Monit 2014; 20:355-60. [PMID: 24584216 PMCID: PMC3945007 DOI: 10.12659/msm.890386] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/09/2022] Open
Abstract
Background Cleft lip and/or palate is the most frequent congenital abnormality occurring in the craniofacial region and is often associated with numerous dental defects such as tooth agenesis, supernumerary teeth, microdontia, taurodontism, crown malformations, or delay in eruption. The prevalence of hypodontia in cleft-affected patients is much higher in comparison with a healthy population. The aim of this study was to evaluate the prevalence of second premolar hypodontia in patients with cleft lip and/or palate. Material/Methods We performed a retrospective, evaluation of panoramic radiographs and dental casts in the Department of Dentofacial Orthopeadics and Orthodontics, Wroclaw Medical University. Two independent observers evaluated the records of 469 patients with various types of clefts and analyzed dental casts and panoramic radiographs. Results 202 individuals met inclusion criteria. The sample comprised 120 UCLP patients, 38 BCLP patients, 28 CP patients, and 17 CLA patients. Hypodontia in the premolar region was observed in 39 individuals (19.3%). A total number of 58 second premolars were missing, of which 35 were maxillary second premolars (U5) and 23 were mandibular second premolars (L5). Conclusions Estimated hypodontia in the Polish CL/P sample was considerably higher than the hypodontia in permanent dentition reported for a European healthy population. The number of congenitally missing second premolars was higher in the maxillary arch than in the mandibular.
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Affiliation(s)
- Marcin Mikulewicz
- Department of Dentofacial Orthopedics and Orthodontics, Division of Facial Abnormalities, Wrocław Medical University, Wrocław, Poland
| | - Tomasz Ogiński
- Department of Dentofacial Orthopedics and Orthodontics, Division of Facial Abnormalities, Wrocław Medical University, Wrocław, Poland
| | - Thomas Gedrange
- Department of Orthodontics, Technische Universität, Dresden, Germany
| | | | - Elżbieta Prussak
- Department of Management in Health Care, University of Medical Sciences, Poznań, Poland
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The multidisciplinary management of fused maxillary lateral incisor with a supernumerary tooth in cleft lip adolescence. Case Rep Dent 2014; 2014:459416. [PMID: 24516763 PMCID: PMC3910257 DOI: 10.1155/2014/459416] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/14/2013] [Accepted: 12/02/2013] [Indexed: 12/22/2022] Open
Abstract
Fusion, an uncommon anomaly of the hard dental tissues, is potentially the cause of clinical problems related to esthetics, tooth spacing, and other periodontal complications. This paper describes a multidisciplinary approach involving surgical, endodontic, restorative, and orthodontic attention for the successful, functional, and esthetic rehabilitation of a maxillary left lateral incisor fused with a supernumerary tooth in unilateral cleft lip adolescence in contralateral side. After clinical and radiographic examinations, a fusion between the left maxillary lateral incisor and a supernumerary tooth was diagnosed in the patient, and a small connection was detected between the pulp systems of the two root canals. The case reported in this paper presents the successful resolution of a fused maxillary lateral incisor with a supernumerary tooth, using endodontic, surgical, restorative, and orthodontic management. The decision made in extracting or retaining the fused tooth depends on the arch discrepancy and esthetic needs. Future studies, with long-term followup, will be helpful in evaluating the long-term efficacy of the different treatment options.
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Ramanathan M, Parameswaran A, Jayakumar N, Sneha P, Sailer HF. A rare case of multiple oblique facial clefts with supernumerary teeth: case report. Craniomaxillofac Trauma Reconstr 2013; 5:239-42. [PMID: 24294408 DOI: 10.1055/s-0032-1329541] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2011] [Accepted: 11/08/2011] [Indexed: 10/27/2022] Open
Abstract
Oblique facial clefts are rare congenital anomalies that can present alone or in association with other craniofacial anomalies. A high degree of clefting in the embryo may lead to hyperdontia secondary to dichotomy of the dental lamina. Multiple facial clefts with hyperdontia are clinically challenging and demand comprehensive rehabilitation. This article reports a case of multiple oblique facial clefts of variable severity with multiple supernumerary teeth in a 12-year-old boy. The varied clinical presentation along with the rarity of the occurrence mandate documentation.
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Rahpeyma A, Khajehahmadi S. Modified VIP-CT flap in late maxillary alveolar cleft surgery. J Craniomaxillofac Surg 2013; 42:432-7. [PMID: 23835570 DOI: 10.1016/j.jcms.2013.05.036] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2012] [Revised: 05/29/2013] [Accepted: 05/29/2013] [Indexed: 11/29/2022] Open
Abstract
OBJECTIVE This article describes a new application for the modified vascularized interpositional periosteal-connective tissue flap (modified VIP-CT flap) to solve problematic cases of late maxillary alveolar cleft bone grafting. METHODS This study analysed the ability of the VIP-CT flap to provide coverage of bone grafts in maxillary alveolar cleft surgery. Donor site morbidity was also evaluated. RESULTS Thirteen patients were operated on using this technique, seven patients were female, the age range was between 12 and 25 years, and all of them were missing at least one permanent anterior tooth adjacent to the cleft. Two patients had bilateral alveolar clefts. In most of the operated patients one VIP-CT flap was used, but in two patients (cases 3 and 4) bilateral VIP-CT flaps were used for treatment of wide alveolar clefts. In case 3 both of the flaps were used for closure of the oral side and in case 4 one flap was used for nasal closure and another for oral side coverage. Two patients had alveolar cleft only with normal palatal anatomy, and the remaining patients had previously operated cleft palates (11 patients). CONCLUSION VIP-CT flaps can readily be used in adult patients with cleft lip (alveolar only) and in many operated unilateral and bilateral complete cleft lip and palate patients successfully.
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Affiliation(s)
- Amin Rahpeyma
- Oral and Maxillofacial Surgeon, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Vakilabad Blvd, Mashhad, Iran.
| | - Saeedeh Khajehahmadi
- Oral and Maxillofacial Pathologist, Dental Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Vakilabad Blvd, Mashhad, Iran.
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30
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Paranaiba LMR, Coletta RD, Swerts MSO, Quintino RP, De Barros LM, Martelli-Júnior H. Prevalence of Dental Anomalies in Patients with Nonsyndromic Cleft Lip and/or Palate in a Brazilian Population. Cleft Palate Craniofac J 2013; 50:400-5. [DOI: 10.1597/11-029] [Citation(s) in RCA: 32] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
Objective Many studies have demonstrated a high frequency of dental anomalies in patients with cleft lip and/or palate. Because dental anomalies may complicate dental treatment, we investigated the prevalence of dental anomalies in a group of Brazilian patients with nonsyndromic cleft lip and/or palate. Design, Participants, Setting Retrospective analysis was performed using clinical records of 296 patients aged between 12 and 30 years with repaired nonsyndromic cleft lip and/or palate without history of tooth extraction and orthodontic treatment. Associations between oral clefts and presence of dental anomalies outside the cleft area were investigated. Results Dental anomalies were identified in 39.9% of the nonsyndromic cleft lip and/or palate patients, and tooth agenesis (47.5%), impacted tooth (13.1%), and microdontia (12.7%) were the most common anomalies. Cleft lip patients were less affected by dental anomalies compared with cleft palate or cleft lip and palate patients ( p = .057). Specifically, patients with unilateral cleft lip and palate were significantly more affected by dental anomalies than those with bilateral cleft lip and palate ( p = .00002), and individuals with unilateral complete cleft lip and palate ( p = .002) and complete cleft palate ( p = .01) were significantly more affected by tooth agenesis than other cleft types. Agenesis of the premolars ( p = .043) and maxillary lateral incisors ( p = .03) were significantly more frequent in patients with unilateral complete cleft lip and palate. Conclusions The present study revealed a high frequency of dental anomalies in nonsyndromic cleft lip and/or palate patients and further demonstrated that patients with unilateral cleft lip and palate were frequently more affected by dental anomalies than those with bilateral cleft lip and palate. Moreover, our results demonstrate that dental anomalies should be considered during dental treatment planning for individuals affected by nonsyndromic cleft lip and/or palate.
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Affiliation(s)
| | - Ricardo D. Coletta
- Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil
| | | | | | | | - Hercílio Martelli-Júnior
- Stomatology Clinic, School of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil
- School of Dentistry, José do Rosário Vellano University, Alfenas, Minas Gerais, Brazil
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31
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Antonarakis GS, Tsiouli K, Christou P. Mesiodistal tooth size in non-syndromic unilateral cleft lip and palate patients: a meta-analysis. Clin Oral Investig 2012; 17:365-77. [PMID: 23011523 DOI: 10.1007/s00784-012-0819-9] [Citation(s) in RCA: 15] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/13/2011] [Accepted: 08/01/2012] [Indexed: 10/28/2022]
Abstract
OBJECTIVES To evaluate, using meta-analysis methodology, mesiodistal tooth dimensions in non-syndromic unilateral cleft lip and palate (CLP) patients. MATERIALS AND METHODS A literature search was conducted using PubMed, Medline, Google Scholar Beta, EMBASE Excerpta Medica, CINAHL, Web of Science, and the Cochrane Collaboration, identifying English and non-English articles reporting on mesiodistal tooth dimensions on the cleft and non-cleft side of non-syndromic unilateral CLP patients. Additional studies were identified by searching reference lists of articles consulted. Only studies with a suitable control group were included. Two examiners independently performed the literature search and data extraction. Using meta-analysis software, data extracted from each selected study were statistically combined using the fixed-effects model. Weighted mean differences, 95 % confidence intervals, and heterogeneity were calculated for each measurement. RESULTS Four articles fulfilling the inclusion criteria were located and included in the meta-analysis. Maxillary incisors and first molars were found to be significantly larger on the non-cleft side while mandibular incisors and premolars were larger on the cleft side, in non-syndromic unilateral CLP patients. On the cleft side, maxillary premolars and second molars were larger in cleft than control patients while incisors were smaller, whereas all mandibular teeth were larger in cleft patients. On the non-cleft side, all maxillary teeth except for the central incisors were larger in the cleft than control patients, while all mandibular teeth were larger in the cleft patients except for lateral incisors. CONCLUSIONS Non-syndromic unilateral CLP patients tend to have larger posterior but smaller anterior teeth compared with the general population. Comparing sides, unilateral CLP patients tend to have smaller maxillary but larger mandibular teeth on the cleft than on the non-cleft side. CLINICAL RELEVANCE Given that obtaining a stable, functional, and esthetic occlusion requires a thorough evaluation of tooth size, knowledge about trends in tooth size variations in CLP patients can help with dental and orthodontic treatment planning.
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Affiliation(s)
- Gregory S Antonarakis
- Department of Orthodontics, Dental School, University of Geneva, 19, rue Barthelemmy-Menn, 1205 Geneva, Switzerland.
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Freitas JADS, Garib DG, Oliveira M, Lauris RDCMC, Almeida ALPFD, Neves LT, Trindade-Suedam IK, Yaedú RYF, Soares S, Pinto JHN. Rehabilitative treatment of cleft lip and palate: experience of the Hospital for Rehabilitation of Craniofacial Anomalies-USP (HRAC-USP)--part 2: pediatric dentistry and orthodontics. J Appl Oral Sci 2012; 20:268-81. [PMID: 22666849 PMCID: PMC3894774 DOI: 10.1590/s1678-77572012000200024] [Citation(s) in RCA: 79] [Impact Index Per Article: 6.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2011] [Accepted: 04/11/2012] [Indexed: 11/22/2022] Open
Abstract
The aim of this article is to present the pediatric dentistry and orthodontic treatment protocol of rehabilitation of cleft lip and palate patients performed at the Hospital for Rehabilitation of Craniofacial Anomalies-University of São Paulo (HRAC-USP). Pediatric dentistry provides oral health information and should be able to follow the child with cleft lip and palate since the first months of life until establishment of the mixed dentition, craniofacial growth and dentition development. Orthodontic intervention starts in the mixed dentition, at 8-9 years of age, for preparing the maxillary arch for secondary bone graft procedure (SBGP). At this stage, rapid maxillary expansion is performed and a fixed palatal retainer is delivered before SBGP. When the permanent dentition is completed, comprehensive orthodontic treatment is initiated aiming tooth alignment and space closure. Maxillary permanent canines are commonly moved mesially in order to substitute absent maxillary lateral incisors. Patients with complete cleft lip and palate and poor midface growth will require orthognatic surgery for reaching adequate anteroposterior interarch relationship and good facial esthetics.
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Affiliation(s)
- José Alberto de Souza Freitas
- Hospital for Rehabilitation of Craniofacial Anomalies, Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil
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Martin MD. Tooth agenesis patterns in bilateral cleft lip/palate (BCLP) indicate possible common genetic pathways. J Evid Based Dent Pract 2010; 10:252-3. [PMID: 21093815 DOI: 10.1016/j.jebdp.2010.09.016] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
Abstract
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION Tooth agenesis patterns in bilateral cleft lip and palate. Bartzela TN, Carels CEL, Bronkhorst EM, Ronning E, Rizell S, Kuijpers-Jagtman AM. Eur J Oral Sci 2010;118:47-52. REVIEWER Michael D. Martin, DMD, MSD, MPH, MA, PhD. PURPOSE/QUESTION Are there patterns of tooth agenesis in BCLP that may indicate genetic contributions common to tooth developmental anomalies and cleft lip/palate? SOURCE OF FUNDING Supported by the Department of Dentistry, Radboud University Nijmegen Medical Center, the Netherlands. TYPE OF STUDY/DESIGN Retrospective cohort. LEVEL OF EVIDENCE Level 2: Limited-quality, patient-oriented evidence. STRENGTH OF RECOMMENDATION GRADE Not applicable.
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