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Inaba O, Inamura Y, Takagi T, Meguro S, Nakata K, Michishita T, Isonaga Y, Tachibana S, Ohya H, Sato A, Miyazaki S, Yamauchi Y, Goya M, Nitta J, Sasano T. Temperature-controlled bipolar radiofrequency ablation: An ex vivo study for optimizing efficacy and safety parameters. Heart Rhythm 2025:S1547-5271(25)00210-3. [PMID: 40024423 DOI: 10.1016/j.hrthm.2025.02.039] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/01/2024] [Revised: 02/04/2025] [Accepted: 02/21/2025] [Indexed: 03/04/2025]
Abstract
BACKGROUND Clear indicators for efficacy and safety of bipolar radiofrequency catheter ablation (BRFA) remain undefined. OBJECTIVE This study aimed to investigate predictive indicators of transmural lesion formation and steam pop in BRFA. METHODS In an ex vivo model, BRFA was performed with either the QDOT Micro or ThermoCool SmartTouch SF as the active catheter and the DiamondTemp ablation (DTA) as the return catheter. Predictors of transmural lesion formation and steam pop occurrence were investigated. RESULTS A total of 391 BRFA applications were conducted under various catheter tip and tissue contact configurations with interelectrode distance of 6-27 mm. The ablation index (AI) adjusted for interelectrode distance was effective in predicting transmural lesion formation, with AI increasing linearly as interelectrode distance increased. Logistic regression revealed that the coefficient for AI was -0.040 (standard error, 0.0067; 95% confidence interval, -0.053 to -0.027; P < .0001); for interelectrode distance, it was 2.2 (standard error, 0.35; 95% confidence interval, 1.5-2.9; P < .0001). The AI required to achieve transmural lesion formation was calculated as AI = 54 × interelectrode distance - 260. Steam pops on the active side occurred only during power-controlled BRFA and were absent with a 45°C cutoff. On the return side, steam pops occurred above 55°C. Higher DTA temperatures resulted in deeper cracks. CONCLUSION An AI adjusted for interelectrode distance strongly predicted transmural lesion formation. Temperature-controlled BRFA with a 45°C cutoff for the active catheter and 55°C for the return catheter may prevent steam pops. Furthermore, steam pops induced by higher electrode temperatures may result in the formation of deeper cracks.
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Affiliation(s)
- Osamu Inaba
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan.
| | - Yukihiro Inamura
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Takamitsu Takagi
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Shin Meguro
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Kentaro Nakata
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Toshiki Michishita
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Yuhei Isonaga
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Shinichi Tachibana
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Hiroaki Ohya
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Akira Sato
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Shinsuke Miyazaki
- Department of Cardiovascular Medicine, Institute of Science Tokyo, Tokyo, Japan
| | - Yasuteru Yamauchi
- Department of Cardiology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan
| | - Masahiko Goya
- Department of Cardiology, International University of Health and Welfare, Mita Hospital, Tokyo, Japan
| | - Junichi Nitta
- Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan
| | - Tetsuo Sasano
- Department of Cardiovascular Medicine, Institute of Science Tokyo, Tokyo, Japan
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Futyma P, Sultan A, Zarębski Ł, Imnadze G, Maslova V, Bordignon S, Kousta M, Knecht S, Pavlović N, Peichl P, Lian E, Kueffer T, Scherr D, Pfeffer M, Moskal P, Cismaru G, Antolič B, Wałek P, Chen S, Martinek M, Kollias G, Derndorfer M, Seidl S, Schmidt B, Lüker J, Steven D, Sommer P, Jastrzębski M, Kautzner J, Reichlin T, Sticherling C, Pürerfellner H, Enriquez A, Wörmann J, Chun JKR. Bipolar radiofrequency ablation of refractory ventricular arrhythmias: results from a multicentre network. Europace 2024; 26:euae248. [PMID: 39331050 PMCID: PMC11495370 DOI: 10.1093/europace/euae248] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/02/2024] [Revised: 09/17/2024] [Accepted: 09/20/2024] [Indexed: 09/28/2024] Open
Abstract
AIMS Advanced ablation strategies are needed to treat ventricular tachycardia (VT) and premature ventricular complexes (PVC) refractory to standard unipolar radiofrequency ablation (Uni-RFA). Bipolar radiofrequency catheter ablation (Bi-RFA) has emerged as a treatment option for refractory VT and PVC. Multicentre registry data on the use of Bi-RFA in the setting of refractory VT and PVC are lacking. The aim of this Bi-RFA registry is to determine its real-world safety, feasibility, and efficacy in patients with refractory VT/PVC. METHODS AND RESULTS Consecutive patients undergoing Bi-RFA at 16 European centres for recurring VT/PVC after at least one standard Uni-RFA were included. Second ablation catheter was used instead of a dispersive patch and was positioned at the opposite site of the ablation target. Between March 2021 and August 2024, 91 patients underwent 94 Bi-RFA procedures (74 males, age 62 ± 13, and prior Uni-RFA range 1-8). Indications were recurrence of PVC (n = 56), VT (n = 20), electrical storm (n = 13), or PVC-triggered ventricular fibrillation (n = 2). Procedural time was 160 ± 73 min, Bi-RFA time 426 ± 286 s, and mean Uni-RFA time 819 ± 697 s. Elimination of clinical VT/PVC was achieved in 67 (74%) patients and suppression of VT/PVC in a further 10 (11%) patients. In the remaining 14 patients (15%), no effect on VT/PVC was observed. Three major complications occurred: coronary artery occlusion, atrioventricular block, and arteriovenous fistula. Follow-up lasted 7 ± 8 months. Nineteen patients (61%) remained VT free. ≥80% PVC burden reduction was achieved in 45 (78%). CONCLUSION These real-world registry data indicate that Bi-RFA appears safe, is feasible, and is effective in the majority of patients with VT/PVC.
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Affiliation(s)
- Piotr Futyma
- Clinical Electrophysiology, St. Joseph's Heart Rhythm Center, University of Rzeszów, Anny Jagiellonki 17, 35-623 Rzeszów, Poland
| | - Arian Sultan
- Heart Center, Department of Electrophysiology, University Hospital Cologne, Cologne, Germany
| | - Łukasz Zarębski
- Clinical Electrophysiology, St. Joseph's Heart Rhythm Center, University of Rzeszów, Anny Jagiellonki 17, 35-623 Rzeszów, Poland
| | - Guram Imnadze
- Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universitaet Bochum, Bad Oeynhausen, Germany
| | - Vera Maslova
- Department of Internal Medicine III (Cardiology and Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH), Kiel, Germany
| | - Stefano Bordignon
- Cardioangiologisches Centrum Bethanien, Department Kardiologie, Markus Krankenhaus, Frankfurt, Germany
| | - Maria Kousta
- Department of Internal Medicine II, Cardiology, Angiology, and Intensive Care Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria
| | - Sven Knecht
- Department of Cardiology, University Hospital Basel, Basel, Switzerland
- Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland
| | - Nikola Pavlović
- Department for Cardiovascular Medicine, University Hospital Dubrava, Zagreb, Croatia
| | - Petr Peichl
- Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
| | - Evgeny Lian
- Department of Internal Medicine III (Cardiology and Intensive Care Medicine), University Hospital Schleswig-Holstein (UKSH), Kiel, Germany
| | - Thomas Kueffer
- Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
| | - Daniel Scherr
- Division of Cardiology, Department of Medicine, Medical University of Graz, Graz, Austria
| | - Michael Pfeffer
- Department of Internal Medicine, Cardiology and Nephrology, Hospital Wiener Neustadt, Wiener Neustadt, Austria
| | - Paweł Moskal
- 1st Department of Cardiology, Interventional Electrocardiology, and Hypertension, Jagiellonian University Medical College, Krakow, Poland
| | - Gabriel Cismaru
- 5th Department of Internal Medicine, Cardiology Rehabilitation, Iuliu Hatieganu University of Medicine and Pharmacy of Cluj Napoca, Cluj Napoca, Romania
| | - Bor Antolič
- Department of Cardiology, University Medical Centre of Ljubljana, Ljubljana, Slovenia
| | - Paweł Wałek
- 1st Clinic of Cardiology and Electrotherapy, Swietokrzyskie Cardiology Centre, Kielce, Poland
- Collegium Medicum, Jan Kochanowski University, Kielce, Poland
| | - Shaojie Chen
- Cardioangiologisches Centrum Bethanien, Department Kardiologie, Markus Krankenhaus, Frankfurt, Germany
| | - Martin Martinek
- Department of Internal Medicine II, Cardiology, Angiology, and Intensive Care Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria
| | - Georgios Kollias
- Department of Internal Medicine II, Cardiology, Angiology, and Intensive Care Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria
| | - Michael Derndorfer
- Department of Internal Medicine II, Cardiology, Angiology, and Intensive Care Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria
| | - Sebastian Seidl
- Department of Internal Medicine II, Cardiology, Angiology, and Intensive Care Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria
| | - Boris Schmidt
- Cardioangiologisches Centrum Bethanien, Department Kardiologie, Markus Krankenhaus, Frankfurt, Germany
| | - Jakob Lüker
- Heart Center, Department of Electrophysiology, University Hospital Cologne, Cologne, Germany
| | - Daniel Steven
- Heart Center, Department of Electrophysiology, University Hospital Cologne, Cologne, Germany
| | - Philipp Sommer
- Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universitaet Bochum, Bad Oeynhausen, Germany
| | - Marek Jastrzębski
- 1st Department of Cardiology, Interventional Electrocardiology, and Hypertension, Jagiellonian University Medical College, Krakow, Poland
| | - Josef Kautzner
- Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
| | - Tobias Reichlin
- Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
| | - Christian Sticherling
- Department of Cardiology, University Hospital Basel, Basel, Switzerland
- Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland
| | - Helmut Pürerfellner
- Department of Internal Medicine II, Cardiology, Angiology, and Intensive Care Medicine, Ordensklinikum Linz Elisabethinen, Linz, Austria
| | - Andres Enriquez
- Clinical Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
| | - Jonas Wörmann
- Heart Center, Department of Electrophysiology, University Hospital Cologne, Cologne, Germany
| | - Julian K R Chun
- Cardioangiologisches Centrum Bethanien, Department Kardiologie, Markus Krankenhaus, Frankfurt, Germany
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Sultan A, Futyma P, Metzner A, Anic A, Richter S, Roten L, Badertscher P, Conte G, Chun JKR. Management of ventricular tachycardias: insights on centre settings, procedural workflow, endpoints, and implementation of guidelines-results from an EHRA survey. Europace 2024; 26:euae030. [PMID: 38363995 PMCID: PMC10872712 DOI: 10.1093/europace/euae030] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2023] [Accepted: 01/24/2024] [Indexed: 02/18/2024] Open
Abstract
Ventricular tachycardia (VT), and its occurrence, is still one of the main reasons for sudden cardiac death and, therefore, for increased mortality and morbidity foremost in patients with structural heart [Kahle A-K, Jungen C, Alken F-A, Scherschel K, Willems S, Pürerfellner H et al. Management of ventricular tachycardia in patients with ischaemic cardiomyopathy: contemporary armamentarium. Europace 2022;24:538-51]. Catheter ablation has become a safe and effective treatment option in patients with recurrent VT [Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Heart Rhythm 2020;17:e2-154]. Previous and current guidelines provide guidance on indication for VT ablation and risk assessment and evaluation of underlying disease. However, no uniform recommendation is provided regarding procedural strategies, timing of ablation, and centre setting. Therefore, these specifics seem to differ largely, and recent data are sparse. This physician-based European Heart Rhythm Association survey aims to deliver insights on not only infrastructural settings but also procedural specifics, applied technologies, ablation strategies, and procedural endpoints. Therefore, these findings might deliver a real-world scenario of VT management and potentially are of guidance for other centres.
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Affiliation(s)
- Arian Sultan
- Department of Electrophysiology, Heart Centre University Hospital Cologne, Germany
| | - Piotr Futyma
- St. Joseph’s Heart Rhythm Centre, Rzeszów, Poland
- Medical College, University of Rzeszów, Rzeszów, Poland
| | - Andreas Metzner
- Department of Cardiology, University Heart and Vascular Centre Hamburg, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
| | - Ante Anic
- Department for Cardiovascular Diseases, University Hospital Centre Split, Spilt, Croatia
| | - Sergio Richter
- Division of Electrophysiology, Department of Internal Medicine and Cardiology, Heart Centre Dresden, University Hospital, Technische Universität Dresden, Dresden, Germany
| | - Laurent Roten
- Inselspital-Bern University Hospital, Department of Electrophysiology University of Bern, Bern, Switzerland
| | - Patrick Badertscher
- Inselspital-Bern University Hospital, Department of Electrophysiology University of Bern, Bern, Switzerland
| | - Giulio Conte
- Division of Cardiology, Cardiocentro Ticino (CCT), Lugano, Switzerland
| | - Julian K R Chun
- Cardioangiologisches Centrum Bethanien, Agaplesion Markus Krankenhaus, Frankfurt am Main, Germany
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Futyma P, Chen S, Enriquez A, Pürerfellner H, Santangeli P. Bipolar ablation of ventricular arrhythmias: Step-by-step. J Cardiovasc Electrophysiol 2023; 34:2599-2606. [PMID: 37968834 DOI: 10.1111/jce.16131] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/13/2023] [Revised: 10/29/2023] [Accepted: 11/01/2023] [Indexed: 11/17/2023]
Abstract
Radiofrequency (RF) ablation of intramural ventricular arrhythmias (VAs) may require advanced ablation techniques to achieve effective energy transfer to the targeted tissue. As an alternative to standard RF ablation, catheter ablation can also be conducted in bipolar configuration when two ablation catheters participate in the RF circuit. This strategy has proved to result in deeper lesion formation and may be effective for eliminating arrhythmias that have been refractory to standard ablation. In this article, we provide a step-by-step guide on when and how to perform bipolar ablation of VAs.
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Affiliation(s)
- Piotr Futyma
- St. Joseph's Heart Rhythm Center, Rzeszów, Poland
- Medical College, University of Rzeszów, Rzeszów, Poland
| | - Shaojie Chen
- Department Kardiologe, Markus Krankenhaus, Cardioangiologisches Centrum Bethanien, Frankfurt am Main, Germany
| | - Andres Enriquez
- Kingston Health Science Centre, Queen's University, Kingston, Ontario, Canada
| | | | - Pasquale Santangeli
- Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
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5
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Marashly Q, Najjar SN, Hahn J, Rector GJ, Khawaja M, Chelu MG. Innovations in ventricular tachycardia ablation. J Interv Card Electrophysiol 2023; 66:1499-1518. [PMID: 35879516 DOI: 10.1007/s10840-022-01311-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/21/2022] [Accepted: 07/18/2022] [Indexed: 11/30/2022]
Abstract
Catheter ablation of ventricular arrhythmias (VAs) has evolved significantly over the past decade and is currently a well-established therapeutic option. Technological advances and improved understanding of VA mechanisms have led to tremendous innovations in VA ablation. The purpose of this review article is to provide an overview of current innovations in VA ablation. Mapping techniques, such as ultra-high density mapping, isochronal late activation mapping, and ripple mapping, have provided improved arrhythmogenic substrate delineation and potential procedural success while limiting duration of ablation procedure and potential hemodynamic compromise. Besides, more advanced mapping and ablation techniques such as epicardial and intramyocardial ablation approaches have allowed operators to more precisely target arrhythmogenic substrate. Moreover, advances in alternate energy sources, such as electroporation, as well as stereotactic radiation therapy have been proposed to be effective and safe. New catheters, such as the lattice and the saline-enhanced radiofrequency catheters, have been designed to provide deeper and more durable tissue ablation lesions compared to conventional catheters. Contact force optimization and baseline impedance modulation are important tools to optimize VT radiofrequency ablation and improve procedural success. Furthermore, advances in cardiac imaging, specifically cardiac MRI, have great potential in identifying arrhythmogenic substrate and evaluating ablation success. Overall, VA ablation has undergone significant advances over the past years. Innovations in VA mapping techniques, alternate energy source, new catheters, and utilization of cardiac imaging have great potential to improve overall procedural safety, hemodynamic stability, and procedural success.
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Affiliation(s)
- Qussay Marashly
- Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
| | - Salim N Najjar
- Division of Cardiology, Baylor College of Medicine, 7200 Cambridge Suite A6.137, MS: BCM621, Houston, TX, 77030, USA
| | - Joshua Hahn
- Division of Cardiology, Baylor College of Medicine, 7200 Cambridge Suite A6.137, MS: BCM621, Houston, TX, 77030, USA
| | - Graham J Rector
- Division of Cardiology, Baylor College of Medicine, 7200 Cambridge Suite A6.137, MS: BCM621, Houston, TX, 77030, USA
| | - Muzamil Khawaja
- Division of Cardiology, Baylor College of Medicine, 7200 Cambridge Suite A6.137, MS: BCM621, Houston, TX, 77030, USA
| | - Mihail G Chelu
- Division of Cardiology, Baylor College of Medicine, 7200 Cambridge Suite A6.137, MS: BCM621, Houston, TX, 77030, USA.
- Baylor St. Luke's Medical Center, Houston, USA.
- Texas Heart Institute, Houston, USA.
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Inaba O, Inamura Y, Takagi T, Sato A, Goya M, Sasano T. First experience of temperature-controlled bipolar radiofrequency ablation of ventricular tachycardia originating from the anterior left ventricle using a diamond-embedded-tip catheter. HeartRhythm Case Rep 2023; 9:529-533. [PMID: 37614391 PMCID: PMC10444555 DOI: 10.1016/j.hrcr.2023.05.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 08/25/2023] Open
Affiliation(s)
- Osamu Inaba
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Yukihiro Inamura
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Takamitsu Takagi
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Akira Sato
- Department of Cardiology, Japanese Red Cross Saitama Hospital, Saitama, Japan
| | - Masahiko Goya
- Department of Cardiology, Tokyo Medical and Dental University, Tokyo, Japan
| | - Tetsuo Sasano
- Department of Cardiology, Tokyo Medical and Dental University, Tokyo, Japan
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Liang Z, Zhang T, Liu L, Qi S, Liu X, Li Q, Fang D, Wang Y, Ma C. Catheter ablation of ventricular premature depolarizations originating from mid interventricular septum: Significance of electrocardiographic morphology for predicting origin. Heart Rhythm 2023:S1547-5271(23)02253-1. [PMID: 37225113 DOI: 10.1016/j.hrthm.2023.05.023] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/16/2023] [Revised: 05/14/2023] [Accepted: 05/16/2023] [Indexed: 05/26/2023]
Abstract
BACKGROUND Ventricular premature depolarizations (VPDs) originating from the mid interventricular septum (IVS) adjacent to the atrioventricular annulus between the His bundle and coronary sinus ostium (mid IVS VPDs) have not been characterized. OBJECTIVE The aim of this study was to investigate the electrophysiological characteristics of mid IVS VPDs. METHODS Thirty-eight patients with mid IVS VPDs were enrolled. The VPDs were divided into different types according to precordial transition of the electrocardiogram (ECG) and the QRS morphology in lead V1. RESULTS 4 types of VPDs were divided. The precordial transition zone appeared earlier and earlier from types 1 to 4. The notch in V1 moved gradually backwards, its amplitude gradually became higher, resulting in transition from left to right bundle branch block morphology in V1 from types 1 to 4. Based on activation and pace mapping, ablation response, and the 3830 electrode pacing morphology in the mid IVS, the 4 types of ECG morphology corresponded, respectively, to an origin in the right endocardial side, right/mid intramural region, left intramural region, and left endocardial side of the mid IVS. An intramural origin was identified for 50% of the VPDs. 89% of mid IVS VPDs could be eliminated. Bilateral ablation (waiting for delayed efficacy) or bipolar ablation was sometimes needed for intramural VPDs. CONCLUSIONS Mid IVS VPDs were found to have unique electrophysiological characteristics. The ECG characteristics of mid IVS VPDs was important in terms of prediction of its exact origin, the choice of ablation method, and the likelihood of treatment being successful.
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Affiliation(s)
- Zhuo Liang
- Department of Cardiology, Beijing Anzhen Hospital, Beijing, China
| | - Tao Zhang
- Department of Cardiology, Beijing Anzhen Hospital, Beijing, China
| | - Lifeng Liu
- Department of Cardiology, Beijing Chaoyang Hospital, Beijing, China
| | - Shuying Qi
- Department of Cardiology, 980(th) Hospital of the Joint Logistic Support Force of PLA, Shijiazhuang, Hebei, China
| | - Xu Liu
- Department of Cardiology, Beijing Anzhen Hospital, Beijing, China
| | - Qiaoyuan Li
- Department of Cardiology, Beijing Anzhen Hospital, Beijing, China
| | - Dongping Fang
- Department of Cardiology, Beijing Anzhen Hospital, Beijing, China
| | - Yunlong Wang
- Department of Cardiology, Beijing Anzhen Hospital, Beijing, China.
| | - Changsheng Ma
- Department of Cardiology, Beijing Anzhen Hospital, Beijing, China.
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Futyma P, Zarębski Ł, Chen S, Enriquez A, Pürerfellner H, Santangeli P. Risk Assessment and Management of Outflow Tract Arrhythmias Refractory to Prior Treatments. CURRENT CARDIOVASCULAR RISK REPORTS 2022. [DOI: 10.1007/s12170-022-00712-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/23/2022]
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Hu Z, Jiang Y, Wang S. Premature ventricular contractions with acute successful radiofrequency catheter ablation near the atrioventricular node using reversed C curve technique. BMC Cardiovasc Disord 2022; 22:390. [PMID: 36045329 PMCID: PMC9429768 DOI: 10.1186/s12872-022-02832-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/07/2022] [Accepted: 08/22/2022] [Indexed: 11/14/2022] Open
Abstract
Background We sought to clarify the electrophysiological (EP) characteristics of premature ventricular contractions (PVCs) with acute successful radiofrequency catheter ablation (RFCA) near the atrioventricular node (AVN). Methods and results Eighteen patients with acute successful RFCA near the AVN were included in this study. Systematic mapping was performed with two mapping methods: antegrade mapping technique (group A) and reversed C curve mapping technique (group R). RFCA was preferentially performed underneath the tricuspid valve (TV) with reversed C curve technique in all patients. The a amplitude/v amplitude ratio during sinus rhythm in group A was significantly larger than in group B (0.19 ± 0.10 vs 0.06 ± 0.02, p < 0.01). The earliest bipolar activation preceded the QRS onset in group A was significantly smaller than in group R (19.6 ± 4.9 vs 24.4 ± 6.6 ms (ms), p < 0.01). Pace mapping in group A and group R demonstrated perfect QRS morphology (12/12) match only in 5.6% (one patient) and 16.7% (3 patients) of patients, respectively. The mean duration of successful RFCA was 8.2 ± 2.4 s in 13 patients (72.2%). Early (within 3 days) and late (one-year) recurrence rates were 5.6% (one patient) and 16.7% (3 patients), respectively. No atrioventricular block occurred during RFCA or the one-year follow up. Conclusions PVCs near the AVN are a subgroup of idiopathic PVCs with distinctive EP features. RFCA using reversed C curve technique is effective and safe for the acute elimination of these challenging AVN-PVCs.
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Zhou B, Yu J, Ju W, Li X, Zhang F, Chen H, Li M, Gu K, Xie X, Cheng D, Wang X, Wu Y, Zhou J, Zhang B, Kojodjojo P, Cao K, Yang B, Chen M. Bipolar Catheter Ablation Strategies for Outflow Tract Ventricular Arrhythmias Refractory to Unipolar Ablation. J Cardiovasc Electrophysiol 2022; 33:1769-1778. [PMID: 35634859 DOI: 10.1111/jce.15579] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/04/2022] [Revised: 05/02/2022] [Accepted: 05/17/2022] [Indexed: 11/28/2022]
Affiliation(s)
- Benjun Zhou
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
- Department of CardiologyThe Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingP.R. China
| | - Jinbo Yu
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Weizhu Ju
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
| | - Xiaorong Li
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Fengxiang Zhang
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
| | - Hongwu Chen
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
| | - Mingfang Li
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
| | - Kai Gu
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
| | - Xin Xie
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Dian Cheng
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Xuecheng Wang
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Yizhang Wu
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Jian Zhou
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Baowei Zhang
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Pipin Kojodjojo
- Department of CardiologyNg Teng Fong General HospitalSingaporeSingapore
| | - Kejiang Cao
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
| | - Bing Yang
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
- Department of Cardiology, Shanghai East HospitalTongji University School of MedicineShanghaiP.R. China
| | - Minglong Chen
- Department of CardiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingP.R. China
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11
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Kahle AK, Jungen C, Alken FA, Scherschel K, Willems S, Pürerfellner H, Chen S, Eckardt L, Meyer C. Management of ventricular tachycardia in patients with ischaemic cardiomyopathy: contemporary armamentarium. Europace 2021; 24:538-551. [PMID: 34967892 DOI: 10.1093/europace/euab274] [Citation(s) in RCA: 16] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/27/2021] [Indexed: 01/10/2023] Open
Abstract
Worldwide, ∼4 million people die from sudden cardiac death every year caused in more than half of the cases by ischaemic cardiomyopathy (ICM). Prevention of sudden cardiac death after myocardial infarction by implantation of a cardioverter-defibrillator (ICD) is the most common, even though not curative, therapy to date. Optimized ICD programming should be strived for in order to decrease the incidence of ICD interventions. Catheter ablation reduces the recurrence of ventricular tachycardias (VTs) and is an important adjunct to sole ICD-based treatment or pharmacological antiarrhythmic therapy in patients with ICM, as conclusively demonstrated by seven randomized controlled trials (RCTs) in the last two decades. However, none of the conducted trials was powered to reveal a survival benefit for ablated patients as compared to controls. Whereas thorough consideration of an early approach is necessary following two recent RCTs (PAUSE-SCD, BERLIN VT), catheter ablation is particularly recommended in patients with recurrent VT after ICD therapy. In this context, novel, pathophysiologically driven ablation strategies referring to deep morphological and functional substrate phenotyping based on high-resolution mapping and three-dimensional visualization of scars appear promising. Emerging concepts like sympathetic cardiac denervation as well as radioablation might expand the therapeutical armamentarium especially in patients with therapy-refractory VT. Randomized controlled trials are warranted and on the way to investigate how these translate into improved patient outcome. This review summarizes therapeutic strategies currently available for the prevention of VT recurrences, the optimal timing of applicability, and highlights future perspectives after a PAUSE in BERLIN.
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Affiliation(s)
- Ann-Kathrin Kahle
- Division of Cardiology, EVK Düsseldorf, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Kirchfeldstrasse 40, 40217 Düsseldorf, Germany.,Institute of Neural and Sensory Physiology, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Heinrich Heine University Düsseldorf, Medical Faculty, Universitätsstrasse 1, 40225 Düsseldorf, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany
| | - Christiane Jungen
- DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany.,Clinic for Cardiology, University Heart & Vascular Center, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.,Willem Einthoven Center for Cardiac Arrhythmia Research and Management, Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands
| | - Fares-Alexander Alken
- Division of Cardiology, EVK Düsseldorf, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Kirchfeldstrasse 40, 40217 Düsseldorf, Germany.,Institute of Neural and Sensory Physiology, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Heinrich Heine University Düsseldorf, Medical Faculty, Universitätsstrasse 1, 40225 Düsseldorf, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany
| | - Katharina Scherschel
- Division of Cardiology, EVK Düsseldorf, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Kirchfeldstrasse 40, 40217 Düsseldorf, Germany.,Institute of Neural and Sensory Physiology, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Heinrich Heine University Düsseldorf, Medical Faculty, Universitätsstrasse 1, 40225 Düsseldorf, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany
| | - Stephan Willems
- DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany.,Department of Cardiology and Internal Intensive Care Medicine, Asklepios Hospital St. Georg, Lohmühlenstrasse 5, 20099 Hamburg, Germany
| | - Helmut Pürerfellner
- Department of Electrophysiology, Academic Teaching Hospital, Ordensklinikum Linz Elisabethinen, Fadingerstraße 1, 4020 Linz, Austria
| | - Shaojie Chen
- Cardioangiologisches Centrum Bethanien (CCB), Frankfurt Academy For Arrhythmias (FAFA), Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Wilhelm-Epstein Straße 4, 60431 Frankfurt am Main, Germany
| | - Lars Eckardt
- Department for Cardiology II (Electrophysiology), University Hospital Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany
| | - Christian Meyer
- Division of Cardiology, EVK Düsseldorf, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Kirchfeldstrasse 40, 40217 Düsseldorf, Germany.,Institute of Neural and Sensory Physiology, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, Heinrich Heine University Düsseldorf, Medical Faculty, Universitätsstrasse 1, 40225 Düsseldorf, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany
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12
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Zhang LY, Dong SJ, Yu HJ, Chu YJ. Ventricular tachycardia originating from the His bundle: A case report. World J Clin Cases 2021; 9:10040-10045. [PMID: 34877348 PMCID: PMC8610906 DOI: 10.12998/wjcc.v9.i32.10040] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/06/2021] [Revised: 08/16/2021] [Accepted: 09/19/2021] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Ventricular tachycardia (VT) commonly occurs among patients with heart failure and can even cause sudden cardiac death. VT originating from the His bundle branch has been rarely reported. We present the case of a patient with VT from the His bundle branch.
CASE SUMMARY A 58-year-old female complained of paroxysmal palpitations and dizziness for approximately 6 mo. She had a history of fatty liver and cholecystitis, and carotid atherosclerosis could not be excluded from the ultrasound results. An evaluation of the electrocardiogram obtained after admission showed spontaneous conversion between two different morphologies. The possible electrophysiologic mechanism suggested that the dual-source VT originated from the same source, the His bundle branch. Finally, the His bundle branch was ablated, and a dual-chamber pacemaker was inserted into the patient’s heart. No further VT occurred during the 3-year follow-up after hospital discharge.
CONCLUSION The diagnosis of VT originating from the His bundle is rare and difficult to establish. The results of this study showed VT originating from the His bundle based on a careful evaluation of the electrocardiogram, and the diagnosis was confirmed by an intracardiac electrophysiologic examination.
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Affiliation(s)
- Lu-Yao Zhang
- Department of Cardiology, Zhengzhou University People’s Hospital, Zhengzhou 450003, Henan Province, China
| | - Shu-Juan Dong
- Department of Cardiology, Zhengzhou University People’s Hospital, Zhengzhou 450003, Henan Province, China
| | - Hai-Jia Yu
- Department of Emergency, Zhengzhou University People’s Hospital, Zhengzhou 450003, Henan Province, China
| | - Ying-Jie Chu
- Department of Cardiology, Zhengzhou University People’s Hospital, Zhengzhou 450003, Henan Province, China
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13
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Futyma P, Chen S. Ablation Target Out of Range: A Journey Deep Into the Interventricular Septum. JACC Case Rep 2021; 3:1125-1127. [PMID: 34471896 PMCID: PMC8314120 DOI: 10.1016/j.jaccas.2021.06.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
Affiliation(s)
- Piotr Futyma
- Department of Cardiology, St Joseph’s Heart Rhythm Center, Rzeszów, Poland
| | - Shaojie Chen
- Department Kardiologe, Markus Krankenhaus, Cardioangiologisches Centrum Bethanien (CCB), Frankfurt am Main, Germany
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14
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Electrocardiographic and electrophysiological characteristics of idiopathic ventricular arrhythmias originating from the vicinity of tricuspid annulus. Sci Rep 2021; 11:8633. [PMID: 33883631 PMCID: PMC8060328 DOI: 10.1038/s41598-021-88036-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2020] [Accepted: 04/07/2021] [Indexed: 11/24/2022] Open
Abstract
Electrocardiographic and electrophysiological characteristics of VAs originating from the vicinity of the TA are not fully understood. Hence, 104 patients (mean age 52.6 ± 17.9 years; 62 male) with VAs originating from the vicinity of the TA were enrolled. After electrophysiological evaluation and ablation, data were compared among those patients. The ECGs and the correction of the ECGs based on the long axis of the heart calculated from the chest X-Ray were also analyzed. VAs originating from the vicinity of TA had distinctive ECG characteristics that were useful for identifying the precise origin. Our localization algorithm adjusted by the angle between the cardiac long axis and the horizon was found to be accurate in predicting the exact ablation site in 92.3% (n = 96) cases. Logistic regression analysis showed fractionated electrograms, the magnitudes of the local atrial electrograms and a/V ratio were critical factors for successful ablation. Among the 104 patients with VAs, complete elimination could be achieved by RFCA in 96 patients (success rate 92.3%) during a follow-up period of 35.2 ± 19.6 months. This study suggests that the ablation site could be localized by ECG analysis adjusted by the angle between the cardiac long axis and the horizon. Fractionated electrograms, the magnitudes of the local atrial electrograms and a/V ratio were demonstrated to be critical factors for successful ablation.
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15
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Pothineni NVK, Garcia FC, Santangeli P. Radiofrequency Ablation Strategies for Intramural Ventricular Arrhythmias. Methodist Debakey Cardiovasc J 2021; 17:8-12. [PMID: 34104314 DOI: 10.14797/peyf3776] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/21/2022] Open
Abstract
Catheter ablation is an established treatment strategy for ventricular arrhythmias. However, the presence of intramural substrate poses challenges with mapping and delivery of radiofrequency energy, limiting overall success of catheter ablation. Advances over the past decade have improved our understanding of intramural substrate and paved the way for innovative treatment approaches. Modifications in catheter ablation techniques and development of novel ablation technologies have led to improved clinical outcomes for patients with ventricular arrhythmias. In this review, we explore mapping techniques to identify intramural substrate and describe available radiofrequency energy delivery techniques that can improve overall success rates of catheter ablation.
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Affiliation(s)
| | - Fermin C Garcia
- Hospital of The University of Pennsylvania, Philadelphia, Pennsylvania
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16
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Yue-Chun L, Yuan-Nan L, Jing X, Yang-Qi P, Cheng Z, Yang-Jing X, Jia-Xuan L, Jin L, Jia L, Jia-Feng L. R/S Ratio in Lead III Predicts Successful Ablation of Ventricular Arrhythmias Originating in Para-Hisian Region. JACC Clin Electrophysiol 2021; 7:719-730. [PMID: 33516713 DOI: 10.1016/j.jacep.2020.10.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/18/2020] [Revised: 10/02/2020] [Accepted: 10/21/2020] [Indexed: 12/01/2022]
Abstract
OBJECTIVES The aim of this study was to investigate the electrocardiographic characteristics of ventricular arrhythmias (VAs) originating near the His bundle (HB) and use the R/S ratio in lead III (RIII/SIII ratio) to predict successful ablation of para-Hisian VAs. BACKGROUND Catheter ablation for idiopathic VAs near the HB is often challenging, and data are limited. METHODS The present study included 134 consecutive patients undergoing catheter ablation of para-Hisian VAs. The electrocardiographic characteristics in these patients were retrospectively evaluated with successful ablation and failed ablation. RESULTS Successful ablation was achieved in 115 (85.8%) of the 134 patients. There was no significant difference in QRS duration between the successful and the failed ablation groups. The ablation success rate was significantly lower for para-Hisian VAs with a predominantly positive R wave in lead III than those with a predominantly negative S wave in lead III. The significant factor associated with successful ablation was the RIII/SIII ratio. The RIII/SIII ratio ≤1.1 predicted the successful ablation of para-Hisian VAs with high sensitivity (80.9%) and specificity (94.7%). The RIII/SIII ratio of >1.2 had high sensitivity (100.0%) and specificity (82.8%) to predict the distance <5 mm from the site of origin of para-Hisian VAs to the site recording the largest HB potential. CONCLUSIONS The RIII/SIII ratio was a helpful predictor of the successful ablation of VAs originating in the vicinity of the HB. This may be useful for planning ablation of para-Hisian VAs and minimizing the risk of inadvertent atrioventricular block.
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Affiliation(s)
- Li Yue-Chun
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Lin Yuan-Nan
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Xu Jing
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Pan Yang-Qi
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Zheng Cheng
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Xue Yang-Jing
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Lin Jia-Xuan
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Li Jin
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Li Jia
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China
| | - Lin Jia-Feng
- Department of Cardiology, Second Affiliated Hospital, and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.
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17
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Anatomic approach with bipolar ablation between the left pulmonic cusp and left ventricular outflow tract for left ventricular summit arrhythmias. Heart Rhythm 2020; 17:1519-1527. [DOI: 10.1016/j.hrthm.2020.04.029] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/24/2020] [Revised: 04/13/2020] [Accepted: 04/15/2020] [Indexed: 11/23/2022]
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18
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Liang JJ, Bogun F. Bipolar ablation for intramural ventricular tachycardia substrate: Ready for prime time? Heart Rhythm 2020; 17:1508-1509. [DOI: 10.1016/j.hrthm.2020.04.034] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/13/2020] [Accepted: 04/14/2020] [Indexed: 01/31/2023]
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19
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Futyma P, Kułakowski P. An update to an update on radiofrequency bipolar catheter ablation. J Cardiovasc Electrophysiol 2020; 31:1238-1239. [PMID: 32125041 DOI: 10.1111/jce.14411] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/10/2020] [Accepted: 02/11/2020] [Indexed: 12/24/2022]
Affiliation(s)
- Piotr Futyma
- Invasive Cardiology Department, St. Joseph's Heart Rhythm Center, Rzeszów, Poland
| | - Piotr Kułakowski
- Invasive Cardiology Department, St. Joseph's Heart Rhythm Center, Rzeszów, Poland.,Department of Cardiology, Medical Centre for Postgraduate Education, Grochowski Hospital, Warsaw, Poland
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