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He YS, Zheng Y. Exploratory operation in a patient with spontaneous temporal bone cerebrospinal fluid leaks: A case report. World J Clin Cases 2025; 13:102279. [DOI: 10.12998/wjcc.v13.i20.102279] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/13/2024] [Revised: 02/21/2025] [Accepted: 03/08/2025] [Indexed: 04/09/2025] Open
Abstract
BACKGROUND Cerebrospinal fluid (CSF) leaks in the temporal bone arise from osteodural defects, resulting in an abnormal connection between the subarachnoid space and the adjacent tympanomastoid cavity, which often manifests as otorrhea. Patients typically exhibit symptoms such as headache, unilateral hearing impairment, aural fullness, or even meningitis. Imaging studies are critical for identifying and differentiating the location and characteristics of CSF leaks. However, when the leak's origin remains ambiguous, diagnostic surgery may be warranted to both confirm the diagnosis and facilitate treatment. This report discusses an uncommon case while reviewing relevant literature, focusing on the surgical diagnostic intervention in a 58-year-old male with spontaneous temporal bone CSF leaks.
CASE SUMMARY The patient, a 58-year-old man, was admitted for evaluation of left ear fullness, hearing loss, and nasal discharge. Notably, when supine, clear fluid drained from the left nasal cavity, with improvement noted upon sitting. A nasal examination did not reveal significant findings, while the otologic evaluation indicated an intact periosteum; however, considerable fluid accumulation was identified within the left middle ear. Despite undergoing multiple periosteal punctures and conservative medical management, the middle ear effusion persisted. Imaging studies, including magnetic resonance imaging (MRI) and computed tomography, confirmed the presence of left-sided CSF otorrhea, and the head MRI indicated potential CSF rhinorrhea. This raised challenges in determining whether the CSF leak originated from the sphenoid sinus or the temporal bone. Given that CSF otorrhea may drain through the external auditory canal and CSF rhinorrhea from the sellar region can present as nasal leakage, differentiation proved complex. In this case, with an intact external auditory canal, CSF from the middle ear was observed to flow into the nasal cavity via the Eustachian tube. Therefore, leakage from both sites could be misconstrued as CSF rhinorrhea, complicating the diagnostic process. Consequently, an exploratory surgical procedure was performed, revealing an incomplete dura mater on the temporal aspect of the petrous bone, which was subsequently repaired.
CONCLUSION Benign intracranial hypertension can result in meningeal protrusion or meningoencephalocele, which may lead to CSF leakage that generally responds favorably to mucosal repair. In instances where imaging fails to identify the source of the leak or when diagnostic options are limited, proactive exploratory surgery is advisable. Although surgical interventions carry inherent risks, the application of endoscopic techniques by experienced surgeons renders this approach a feasible choice for addressing both diagnostic and therapeutic challenges.
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Affiliation(s)
- Yuan-Song He
- The First Clinical Medical College, Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China
| | - Yong Zheng
- Department of Neurosurgery, The People’s Hospital of Bao’an Shenzheng, Shenzhen 518000, Guangdong Province, China
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Spinos D, Varoutis P, Geropoulos G, Vavoulis G, Georgountzos G, Karela NR, Papageorgakopoulou M, Evangelou K, Muzaffar J, Cho WS. Surgical Outcomes Comparison of Spontaneous Middle Cranial Fossa Cerebrospinal Fluid Leaks: Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg 2025. [PMID: 40298074 DOI: 10.1002/ohn.1279] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/18/2025] [Revised: 03/25/2025] [Accepted: 04/12/2025] [Indexed: 04/30/2025]
Abstract
OBJECTIVE Spontaneous cerebrospinal fluid (sCSF) leaks of lateral skull base have little consensus on optimal management. We synthesized and evaluated current literature via systematic and meta-analysis to compare the success rates and complications of the different surgical techniques for middle cranial fossa (MCF) sCSF leak repair. DATA SOURCES MEDLINE, EMBASE, and Cochrane Library. REVIEW METHODS Studies selected concerned surgical treatment of MCF sCSF leak. Data extracted included the following: study characteristics, patient characteristics, primary outcomes, and secondary outcomes. RESULTS From 297 repairs with a MCF approach, the complication rate was 16.2% (95% CI: 12.3%-21.1%, I2 = 0%, P = .052), compared to transmastoid (TM) 12.2% (95% CI: 6.7%- 21.2%, I2 = 0%) in 82 repairs and for combined approaches 11.9% (95% CI: 4.2%-29.6%, I2 = 58%) in 98 repairs. The rate of recurrence with the MCF approach was 3.2% (95% CI: 1%-6.4%, I2 = 10%, P = .21) in 297 repairs, in the TM group the rate was 8.6% (95% CI: 4.7%-15%, I2 = 0%) in 125 procedures and 1.1% in the combined approaches group (0%-4.5%, I2 = 0%) in 139 procedures. Analysis of reoperation rates revealed a proportion of 0.9% (95% CI: 0%-4.4%, I2 = 51%) in 287 repairs via the MCF approach. Reoperation rate was 8.6% (95% CI: 4.7%- 15%, I2 = 0%) in 125 repairs via TM and 1.1% (95% CI: 0%-4.5%, I2 = 0%) in 139 combined approach repairs. CONCLUSION There is no statistically significant difference in the outcomes of repair techniques. Decision making for the preferred approach will be dependent on the location, size and number of the defects, hearing status, and in consultation with the patient.
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Affiliation(s)
- Dimitrios Spinos
- Department of Cancer and Genomics, School of Medicine, University of Birmingham, Birmingham, UK
- Department of Otolaryngology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
| | - Panagiotis Varoutis
- Department of Neurosurgery, General Hospital of Thessaloniki Ippokratio, Thessaloniki, Thessaloniki, Greece
| | | | - Georgios Vavoulis
- Department of Neurosurgery, General Attica Hospital "KAT", Athens, Greece
| | - Georgios Georgountzos
- Department of Neurosurgery, General Hospital of Nikaia "Agios Panteleimon", Athens, Greece
| | - Nina Rafailia Karela
- Department of Neurosurgery, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany
| | | | - Kyriacos Evangelou
- School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
| | - Jameel Muzaffar
- Department of Otolaryngology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
| | - Wai Sum Cho
- Department of Otolaryngology, Nottingham University Hospitals NHS Trust, Nottingham, UK
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Ungar OJ, Chaushu H, Oron Y, Abu-Eta R, Handzel O. Middle ear secretions following spontaneous CSF leak repair may represent effusion rather than CSF leak. Eur Arch Otorhinolaryngol 2024:10.1007/s00405-024-09167-x. [PMID: 39739019 DOI: 10.1007/s00405-024-09167-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/09/2024] [Accepted: 12/13/2024] [Indexed: 01/02/2025]
Abstract
OBJECTIVE To characterize middle ear (ME) effusion still present 2 months after repair surgery for spontaneous cerebrospinal fluid (CSF) leak via the temporal bone (TB). STUDY DESIGN A retrospective chart review (2011-2022). SETTING Tertiary referral academic center. SUBJECTS AND METHODS All patients with persistent ME effusion at 2 months after surgery were included in this study. The indication for surgery for spontaneous TB CSF leak was an active CSF leak with tegmen dehiscence. The presence of effusion was established by findings on microscopic otoscopy aided by tympanocentesis.ME with effusion were sampled for the presence of 𝛽2transferrin. Those negative for 𝛽2transferrin had a ventilation tube placed for ME aeration of serous otitis media (SOM). Data on persistent fluid leakage from tympanostomy tubes, presence or absence of 𝛽2transferrin in the ME, and residual air-bone gap on the postoperative audiogram were recorded. RESULTS Fifty-three ears underwent surgery to repair a CSF leak, 42 via a middle fossa craniotomy and 11 via transmastoid approaches. Fourteen ears (26%) still had ME effusion 2 months after surgery and it was sampled for 𝛽2transferrin. Seven were negative (SOM or mucoid OM) and the patients received a tympanostomy tube with resultant ME aeration and air-bone gap closure. The other seven underwent revision surgery. CONCLUSIONS Postoperative ME fluid after surgery for TB CSF leak may often represent effusion by SOM rather than an ongoing or recurrent CSF leak. ME effusion by SOM is likely caused by mucosal irritation from long-standing stagnant CSF or an underlying eustachian tube dysfunction.
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Affiliation(s)
- Omer J Ungar
- Departments of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, School of Medicine, Tel Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, 6423907, Israel.
- Affiliated to the School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
| | - Hen Chaushu
- Departments of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, School of Medicine, Tel Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, 6423907, Israel
- Affiliated to the School of Medicine, Tel-Aviv University, Tel Aviv, Israel
| | - Yahav Oron
- Departments of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, School of Medicine, Tel Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, 6423907, Israel
- Affiliated to the School of Medicine, Tel-Aviv University, Tel Aviv, Israel
| | - Rani Abu-Eta
- Departments of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, School of Medicine, Tel Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, 6423907, Israel
- Affiliated to the School of Medicine, Tel-Aviv University, Tel Aviv, Israel
| | - Ophir Handzel
- Departments of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, School of Medicine, Tel Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, 6423907, Israel
- Affiliated to the School of Medicine, Tel-Aviv University, Tel Aviv, Israel
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Quimby AE, De Ravin E, Eliades SJ, Brant JA, Bigelow D, Ruckenstein MJ. Meningitis Risk and Role of Prophylactic Antibiotics in Spontaneous Lateral Skull Base CSF Leaks. Ann Otol Rhinol Laryngol 2023; 132:1600-1609. [PMID: 37246394 PMCID: PMC10571388 DOI: 10.1177/00034894231177756] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/30/2023]
Abstract
OBJECTIVE To review the literature and our institutional experience regarding the risk of meningitis in patients with spontaneous lateral skull base cerebrospinal fluid (sCSF) leaks awaiting surgical repair, and the roles of antibiotic prophylaxis and pneumococcal vaccination, if known. METHODS A retrospective chart review and systematic review of the literature was undertaken to identify the incidence of meningitis in patients with sCSF leaks awaiting surgical repair. Adults managed surgically for sCSF leaks at an academic tertiary care center over a 10-year period were included. Data was collected on receipt of prophylactic antibiotics and/or pneumococcal vaccines during the timeframe between diagnosis and surgical repair. RESULTS Institutional review identified 87 patients who underwent surgical repair of spontaneous leaks, with a 0% incidence of meningitis over a median duration of 2 months while awaiting surgery (mean 5.5 months, range 0.5-118 months). Eighty-eight percent of patients did not receive prophylactic antibiotics. No studies in the published literature demonstrated the impact of prophylactic antibiotics or pneumococcal vaccine on meningitis risk. CONCLUSIONS There appears to be a low risk of meningitis among patients with lateral skull base sCSF leaks awaiting surgery for short durations (≤2 months), even in the absence of prophylactic antibiotics. There is a substantial gap in the published literature assessing the risk of meningitis and roles of antibiotics and vaccination in this patient population, indicating the need for large-scale study to conclusively elucidate the nature of this risk.
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Affiliation(s)
- Alexandra E. Quimby
- Department of Otorhinolaryngology – Head & Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
| | - Emma De Ravin
- Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | - Steven J. Eliades
- Department of Otorhinolaryngology – Head & Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
- Department of Head and Neck Surgery & Communication Sciences, Duke University Medical Center, Durham, NC, USA
| | - Jason A. Brant
- Department of Otorhinolaryngology – Head & Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA
| | - Douglas Bigelow
- Department of Otorhinolaryngology – Head & Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
| | - Michael J. Ruckenstein
- Department of Otorhinolaryngology – Head & Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
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Abstract
OBJECTIVES Describe the diagnosis and management of lateral skull base (LSB) cerebrospinal fluid (CSF) leaks originating from the lateral ventricle. STUDY DESIGN Retrospective case review. SETTING Tertiary referral academic center. PATIENTS Patients with CSF leaks with direct communication to the lateral ventricle on preoperative imaging. INTERVENTION Surgical repair via the middle cranial fossa (MCF) approach. MAIN OUTCOME MEASURES CSF leak patient characteristics (age, sex, body mass index [BMI]) and postoperative course (complications and CSF leak resolution) were collected. RESULTS Three patients had CSF leaks from the lateral ventricle and all patients demonstrated encephalomalacia of the temporal lobe on preoperative imaging. Encephalomalacia resulted from trauma in one case (age 5) and neurodegeneration in two cases (age 77 and 84). BMI ranged from 16.3 to 26.6 mg/kg2 and follow-up ranged from 4 to 21 months. Two patients presented with preoperative meningitis and all patients had resolution of CSF leaks after MCF repair. With the exception of the higher rate of meningitis, patient presentations did not differ from other spontaneous CSF leaks through middle fossa defects. There were no minor or major postoperative complications. CONCLUSIONS CSF leaks from the lateral ventricle represent a rare subset of LSB CSF leaks and can occur in non-obese patients secondary to temporal lobe encephalomalacia. The MCF approach allows for repair of the dura and skull base in this cohort of patients with high-flow CSF leaks and loss of brain parenchyma.
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Hong CS, Kundishora AJ, Elsamadicy AA, Vining EM, Manes RP, Omay SB. A Unique Subset: Idiopathic Intracranial Hypertension Presenting as Spontaneous CSF Leak of the Anterior Skull Base. Skull Base Surg 2021; 83:105-115. [DOI: 10.1055/s-0040-1716898] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/02/2020] [Accepted: 08/09/2020] [Indexed: 10/22/2022]
Abstract
Abstract
Introduction Spontaneous cerebrospinal fluid (CSF) leaks represent a unique clinical presentation of idiopathic intracranial hypertension (IIH), lacking classical features of IIH, including severe headaches, papilledema, and markedly elevated opening pressures.
Methods Following a single-institution retrospective review of patients undergoing spontaneous CSF leak repair, we performed a literature review of spontaneous CSF leak in patients previously undiagnosed with IIH, querying PubMed.
Results Our literature review yielded 26 studies, comprising 716 patients. Average age was 51 years with 80.8% female predominance, and average body mass index was 35.5. Presenting symptoms included headaches (32.5%), visual disturbances (4.2%), and a history of meningitis (15.3%). Papilledema occurred in 14.1%. An empty sella was present in 77.7%. Slit ventricles and venous sinus stenosis comprised 7.7 and 31.8%, respectively. CSF leak most commonly originated from the sphenoid sinus (41.1%), cribriform plate (25.4%), and ethmoid skull base (20.4%). Preoperative opening pressures were normal at 22.4 cm H2O and elevated postoperatively to 30.8 cm H2O. 19.1% of patients underwent shunt placement. CSF leak recurred after repair in 10.5% of patients, 78.6% involving the initial site. A total of 85.7% of these patients were managed with repeat surgical intervention, and 23.2% underwent a shunting procedure.
Conclusion Spontaneous CSF leaks represent a distinct variant of IIH, distinguished by decreased prevalence of headaches, lack of visual deficits, and normal opening pressures. Delayed measurement of opening pressure after leak repair may be helpful to diagnose IIH. Permanent CSF diversion may be indicated in patients exhibiting significantly elevated opening pressures postoperatively, refractory symptoms of IIH, or recurrent CSF leak.
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Affiliation(s)
- Christopher S. Hong
- Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, Connecticut, United States
| | - Adam J. Kundishora
- Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, Connecticut, United States
| | - Aladine A. Elsamadicy
- Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, Connecticut, United States
| | - Eugenia M. Vining
- Division of Otolaryngology, Department of Surgery, Yale School of Medicine, Yale University, New Haven, Connecticut, United States
| | - R. Peter Manes
- Division of Otolaryngology, Department of Surgery, Yale School of Medicine, Yale University, New Haven, Connecticut, United States
| | - Sacit Bulent Omay
- Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, Connecticut, United States
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