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Hekimoglu A, Ergun O, Birgi E, Turan A, Hekimoglu B. Evaluation of Renal Artery Variations in Horseshoe Kidneys with Computed Tomography. UROLOGY RESEARCH & PRACTICE 2023; 49:125-130. [PMID: 37877860 PMCID: PMC10192719 DOI: 10.5152/tud.2023.22222] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/26/2022] [Accepted: 12/19/2022] [Indexed: 10/26/2023]
Abstract
OBJECTIVE Horseshoe kidney is the most common renal fusion anomaly, accounting for 90%. The study aims to explore the variations in the renal arteries of individuals with horseshoe kidney anomalies and contribute to the classification in the literature. MATERIALS AND METHODS Computed tomography images of 145 individuals who had intravenous contrast-enhanced abdominal computed tomography for any reason and had horseshoe kidney anomalies were analyzed retrospectively, and the presence, origin, and number of accessory renal arteries were evaluated. Then, classification was performed according to the origin of the accessory arteries. RESULTS In 145 individuals, 44 different combinations of the accessory artery according to the origin and number were obtained. Most common accessory artery combination was type 2a (M1). According to our classification, 13.1% of the patients were type 1, 57.2% were type 2, 17.2% were type 3, 10.3% were type 4, and 1.4% were type 5. CONCLUSION The classifications of arterial variations in horseshoe kidney anomalies did not match each other in previous studies and did not comprise all patients because they were conducted with a small number of cases. A more comprehensive new classification was created in our study according to accessory artery origins with the help of previous studies.
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Affiliation(s)
- Azad Hekimoglu
- Department of Radiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
| | - Onur Ergun
- Department of Radiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
| | - Erdem Birgi
- Department of Radiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
| | - Aynur Turan
- Department of Radiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
| | - Baki Hekimoglu
- Department of Radiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
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Hermi A, Bibi M, Mrad Dali K, Hadj Alouane H, Ben Rhouma S, Nouira Y. A case report of non-functional ectopic left kidney obstructing the right kidney in crossed fused kidneys: A rare entity. Int J Surg Case Rep 2021; 86:106321. [PMID: 34474327 PMCID: PMC8408628 DOI: 10.1016/j.ijscr.2021.106321] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/13/2021] [Revised: 08/14/2021] [Accepted: 08/15/2021] [Indexed: 12/05/2022] Open
Abstract
Introduction and importance Crossed fused renal ectopia is a rare congenital condition that might pose some diagnostic and therapeutic challenges to clinicians. We report a patient with a non-functional crossed fused ectopic left kidney that obstructed the orthotopic kidney in a rarely observed situation. Case presentation A 68-year-old male presented a right flank pain with fever. The diagnosis of right obstructive pyelonephritis was dressed, after biological and radiological investigations. The obstacle was a crossed ectopic left kidney in its inferior variety. The ectopic kidney was non-functional as result of an obstructive ureteral calculus. The patient had right ureteral stenting with a double-J catheter. Three months later, left nephrectomy was performed by lumbotomy. Per operative difficulties were mainly the infiltration of peri renal fat, the anarchic vascularization and the multiple small pedicles of the ectopic kidney that was also malrotated with the hilum facing anteriorly. Postoperative recovery was uneventful and the patient left the hospital after three days. Clinical discussion Crossed Fused renal ectopy is rare. As shown in this case, the ectopic kidney might cause damage to the orthotopic kidney, by compression to urinary ducts. Surgery is the main treatment option. Some difficulties related to aberrant vascularization and possible malrotation is to preview. Conclusion Crossed fused renal ectopia is uncommon renal anomaly, mostly asymptomatic. However, it may be responsible of some complications, sometimes severe. Surgery can be delicate due to vascular complexity.
Crossed renal fused ectopy is rare and asymptomatic congenital condition. Association to other malformations is possible. The ectopic kidney may be responsible of the obstruction and the mal function of the orthotopic kidney. This is the first case to be reported in literature. Surgery might be difficult due to aberrant vascularization and possible malrotation of the kidney.
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Affiliation(s)
- Amine Hermi
- University Tunis Manar, Faculty of Medicine of Tunis, Department of Urology, La Rabta Hospital, Tunis, Tunisia.
| | - Mokhtar Bibi
- University Tunis Manar, Faculty of Medicine of Tunis, Department of Urology, La Rabta Hospital, Tunis, Tunisia
| | - Kheireddine Mrad Dali
- University Tunis Manar, Faculty of Medicine of Tunis, Department of Urology, La Rabta Hospital, Tunis, Tunisia
| | - Houssem Hadj Alouane
- University Tunis Manar, Faculty of Medicine of Tunis, Department of Urology, La Rabta Hospital, Tunis, Tunisia
| | - Sami Ben Rhouma
- University Tunis Manar, Faculty of Medicine of Tunis, Department of Urology, La Rabta Hospital, Tunis, Tunisia
| | - Yassine Nouira
- University Tunis Manar, Faculty of Medicine of Tunis, Department of Urology, La Rabta Hospital, Tunis, Tunisia
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Kassab GH, Robinson I, Hayes R, Paltiel HJ, Bates DG, Cohen HL, Barth RA, Colleran GCM. Urinary Tract. PEDIATRIC ULTRASOUND 2021:729-833. [DOI: 10.1007/978-3-030-56802-3_17] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/03/2025]
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Bakshi S. Incidentally detected pancake kidney: a case report. J Med Case Rep 2020; 14:129. [PMID: 32792017 PMCID: PMC7427080 DOI: 10.1186/s13256-020-02455-0] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/21/2020] [Accepted: 07/08/2020] [Indexed: 11/12/2022] Open
Abstract
Background Congenital anomalies of the urinary system are very common and have extremely varied presentation. Among them, the most rarely found structural anomaly is the pancake kidney. When both kidneys are fused along their medial surfaces to form a round-shaped single renal mass, it is termed as pancake kidney. In this case report, a pancake kidney was incidentally detected in a girl. The majority of individuals who have pancake kidney are usually asymptomatic but surgeons should be aware of coexisting malformation of other organs and its potential risk of developing malignancy. Case presentation A 12-year-old Bengali girl presented to our out-patient department with mild, dull aching, lower abdominal pain and dysuria. She had no history of fever, hematuria, menstrual abnormality, pelvic inflammatory disease, or trauma. Urine examination showed traces of albumin and 10–12 pus cells/high-power field. She had normal kidney function test but a digital X-ray of her kidney, ureter, and bladder region failed to demonstrate bilateral renal tissue shadows. Ultrasonography of her whole abdomen showed normal intra-abdominal organs except for empty bilateral renal fossa. A multi-detector computed tomography scan of her whole abdomen revealed one round-shaped mass measuring approximately 9 cm (vertical) × 10 cm (horizontal) in the pelvic cavity. That mass was finally identified as a pancake kidney. She was prescribed antibiotics based on urine culture and sensitivity test that cured her symptoms. She was advised to follow-up regularly in our out-patient department to evaluate her kidney function and to rule out any neoplastic change. Conclusions This condition can be managed conservatively, if the individual remains asymptomatic, by regular monitoring of renal function. Surgeons should remain alert for the development of infections, any obstructive manifestations leading to calculus formation, and any malignant changes. The individual should be careful in avoiding trauma to low-lying pelvic kidney. Extensive surgeries should be avoided and only selective procedures should be done so that the patient may lead a normal lifestyle.
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Affiliation(s)
- Sabyasachi Bakshi
- Department of General surgery, BSMCH, Bankura, West Bengal, PIN-722102, India. .,, Kathghara Lane,Sonatuli, Hooghly, 712103, West Bengal, India.
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Ozima BAI, de Arruda JGF, Gatti M, de Arruda GJF, Spessoto LCF, Fácio FN. Cake kidney drained though a single ureter in a patient with recurring urinary tract infection. Transl Androl Urol 2020; 8:762-763. [PMID: 32038974 DOI: 10.21037/tau.2019.10.14] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/06/2022] Open
Abstract
Cake kidney is a rare abnormality of the urinary tract. It is generally asymptomatic but can lead to renal and nonspecific systemic manifestations. This report describes a case of cake kidney drained through a single ureter diagnosed in a female patient with recurring urinary infection.
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Affiliation(s)
| | - José Germano Ferraz de Arruda
- Department of Urology, São José do Rio Preto School of Medicine (FAMERP/FUNFARME), São José do Rio Preto, SP, Brazil
| | - Marcio Gatti
- Department of Urology, São José do Rio Preto School of Medicine (FAMERP/FUNFARME), São José do Rio Preto, SP, Brazil
| | - Germano José Ferraz de Arruda
- Department of Urology, São José do Rio Preto School of Medicine (FAMERP/FUNFARME), São José do Rio Preto, SP, Brazil
| | - Luís Cesar Fava Spessoto
- Department of Urology, São José do Rio Preto School of Medicine (FAMERP/FUNFARME), São José do Rio Preto, SP, Brazil
| | - Fernando Nestor Fácio
- Department of Urology, São José do Rio Preto School of Medicine (FAMERP/FUNFARME), São José do Rio Preto, SP, Brazil
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Use of Hypothermic Machine Perfusion to Identify Anatomic Variation Before Transplantation of a Pancake Kidney: A Case Report. Transplant Direct 2019; 5:e445. [PMID: 31165080 PMCID: PMC6511441 DOI: 10.1097/txd.0000000000000891] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/14/2019] [Revised: 03/05/2019] [Accepted: 03/06/2019] [Indexed: 11/26/2022] Open
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Choi T, Yoo KH, Song R, Lee DG. Lump type crossed fused renal ectopia with bilateral vesicoureteral reflux: A case report. World J Clin Cases 2019; 7:773-777. [PMID: 30968043 PMCID: PMC6448078 DOI: 10.12998/wjcc.v7.i6.773] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/09/2019] [Revised: 01/31/2019] [Accepted: 02/18/2019] [Indexed: 02/05/2023] Open
Abstract
BACKGROUND Crossed fused renal ectopia is a rare congenital anomaly of the ascent of the kidney. This anomaly may be observed as a solitary kidney during initial evaluation. A solitary kidney must be evaluated for associated anomalies such as duplication, horseshoe kidney, or crossed renal ectopia.
CASE SUMMARY An anomaly was observed in a 9-mo-old male child who was subsequently diagnosed with crossed fused renal ectopia and vesicoureteral reflux (VUR). In this condition, recurrent febrile urinary tract infection can be a serious problem, and can easily cause renal damage due to relatively short ureters and high pressure in the kidney.
CONCLUSION To prevent urosepsis and preserve renal function, early diagnosis and proper management including surgical correction should be considered for the management of renal ectopia with VUR.
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Affiliation(s)
- Taesoo Choi
- Koo Han, Yoo, Dong-Gi Lee, Department of Urology, School of Medicine, Kyung Hee University, Seoul 05278, South Korea
| | | | - Ran Song
- Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul 05278, South Korea
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Slongo J, Wiegand LR. Pancake Kidney With Obstructed Moiety: A Rare Renal Fusion Anomaly. Urol Case Rep 2017; 12:67-69. [PMID: 28373961 PMCID: PMC5376259 DOI: 10.1016/j.eucr.2017.03.003] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2016] [Accepted: 03/02/2017] [Indexed: 11/28/2022] Open
Abstract
Renal fusion abnormalities are rare. Even more rare is pancake kidney. We present a case of a 28-year-old male with symptomatic obstruction of a non-functioning moiety of a pancake kidney. He underwent ureterectomy with a finding of only atretic renal parenchyma at exploration. He recovered well and had resolution of his pain at 3-month follow-up.
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Affiliation(s)
- Julio Slongo
- University of South Florida - Morsani College of Medicine, Department of Urology, 2 Tampa General Circle - STC6, Tampa, FL 33606, USA
| | - Lucas R Wiegand
- University of South Florida - Morsani College of Medicine, Department of Urology, 2 Tampa General Circle - STC6, Tampa, FL 33606, USA
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Al-Hamar NE, Khan K. Crossed nonfused renal ectopia with variant blood vessels: a rare congenital renal anomaly. Radiol Case Rep 2016; 12:59-64. [PMID: 28228880 PMCID: PMC5310254 DOI: 10.1016/j.radcr.2016.10.016] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/05/2016] [Revised: 10/22/2016] [Accepted: 10/23/2016] [Indexed: 11/30/2022] Open
Abstract
Crossed renal ectopia is a rare congenital anomaly, where one of the kidneys crosses the midline and lies opposite to the site of its normal ureteral insertion. Ninety percent of crossed ectopic kidneys are fused to their ipsilateral uncrossed kidney. Crossed renal ectopia without fusion is rare. We present the case of a 53-year-old male with an unusual incidental finding of crossed nonfused renal ectopia, with the left ectopic kidney lying anterior to the right kidney without fusion. The ectopic kidney had dual arterial supply: one from the aorta and another from the right renal artery. It also demonstrated dual venous drainage; a main left renal vein and an accessory renal vein. The main left renal vein joined the right renal vein to form a common renal vein before draining into the inferior vena cava. The accessory renal vein joined the left testicular and left lumbar veins to drain into the inferior vena cava. Multiple bilateral nonobstructing renal calculi were also noted. Although the patient was asymptomatic, the authors highlight potential complications related to the above-mentioned condition and the importance of identification of the findings.
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da Silva RM, de Morais Júnior MF, Mont'Alverne Filho FE. Pancake kidney with cysts and a single ureter. Radiol Bras 2016; 49:127-8. [PMID: 27141139 PMCID: PMC4851487 DOI: 10.1590/0100-3984.2015.0063] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/21/2022] Open
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11
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Musiienko A, Simpson JAD, Murphy D, Thomson B, Heriot A. Low anterior resection adjacent to a pancake kidney: case report. ANZ J Surg 2015; 87:E333-E334. [PMID: 26011689 DOI: 10.1111/ans.13198] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
Affiliation(s)
- Anton Musiienko
- Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
| | | | - Declan Murphy
- Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
| | - Benjamin Thomson
- Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
| | - Alexander Heriot
- Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
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Miclaus GD, Pupca G, Gabriel A, Matusz P, Loukas M. Right lump kidney with varied vasculature and urinary system revealed by multidetector computed tomographic (MDCT) angiography. Surg Radiol Anat 2014; 37:859-65. [DOI: 10.1007/s00276-014-1390-7] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/30/2014] [Accepted: 10/21/2014] [Indexed: 10/24/2022]
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13
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Gun S, Ciantelli GL, Takahashi MAU, Brabo AM, Morais LAD, Figueiredo CB. Fusão renal completa em criança com infecção recorrente do trato urinário. Radiol Bras 2012. [DOI: 10.1590/s0100-39842012000400011] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
O rim em bolo é uma rara anormalidade do trato urinário que pode ser diagnosticada em qualquer faixa etária. Durante investigação de infecção urinária recorrente em criança de 12 anos, foi revelada em tomografia computadorizada contrastada a presença de rim direito ectópico, com fusão renal, drenado por dois ureteres. Foi iniciado tratamento profilático com nitrofurantoína e o paciente se encontra assintomático.
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Al Kaissi A, Ganger R, Hofstaetter JG, Klaushofer K, Grill F. The aetiology behind torticollis and variable spine defects in patients with Müllerian duct/renal aplasia-cervicothoracic somite dysplasia syndrome: 3D CT scan analysis. EUROPEAN SPINE JOURNAL : OFFICIAL PUBLICATION OF THE EUROPEAN SPINE SOCIETY, THE EUROPEAN SPINAL DEFORMITY SOCIETY, AND THE EUROPEAN SECTION OF THE CERVICAL SPINE RESEARCH SOCIETY 2011; 20:1720-7. [PMID: 21553338 PMCID: PMC3175860 DOI: 10.1007/s00586-011-1835-1] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/29/2010] [Revised: 03/17/2011] [Accepted: 04/25/2011] [Indexed: 10/18/2022]
Abstract
The aim of the article is fourfold; firstly, to detect the aetiology of torticollis in patients with Müllerian duct/renal aplasia-cervicothoracic somite dysplasia syndrome; secondly, spine pathology in Müllerian duct/renal aplasia-cervicothoracic somite dysplasia syndrome varies considerably from one patient to another and there are remarkable differences in severity and localization; thirdly, mismanagement of congenital spine pathology is a frequent cause of morbid/fatal outcome; and fourthly, the application of prophylactic surgical treatment to balance the growth of the spine at an early stage is mandatory. Reformatted CT scans helped in exploring the craniocervical and the entire spine in these patients. The reason behind torticollis ranged between aplasia of the posterior arch of the atlas, assimilation of the atlas and extensive fusion of the lower cervical vertebrae (bilateral failure of segmentation) in four patients; in one patient, in addition to the hypoplastic posterior arch of the atlas, we observed ossification of the anterior and the posterior longitudinal spinal ligaments giving rise to a block vertebrae-like suggestive of early senile ankylosing vertebral hyperostosis (Forestier disease). Scoliosis at different spine levels was attributable to variable spine defects. Pelvic ultrasound showed the classical renal agenesis in four patients; whereas in one patient, the MRI showed pelvic cake kidney (renal fused ectopia) associated with ovarian, uterine and vaginal abnormalities. This is the first exploratory study on the craniocervical and the entire spine in a group of patients with MURCS association.
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Affiliation(s)
- Ali Al Kaissi
- 4th Medical Department, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK, AUVA Trauma Centre Meidling, Hanusch Hospital, Heinrich Collin Str. 30, 1140 Vienna, Austria.
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Rosenkrantz AB, Kopec M, Laks S. Pelvic Cake Kidney Drained by a Single Ureter Associated With Unicornuate Uterus. Urology 2010; 76:53-4. [DOI: 10.1016/j.urology.2009.10.015] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/14/2009] [Revised: 09/26/2009] [Accepted: 10/12/2009] [Indexed: 10/20/2022]
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Ignjatovic I, Stojkovic I, Dinic LJ, Jovanovic M, Ivanovic D. Bilateral fused pelvic kidney ectopia with a single draining ureter solved by craniolateral displacement of the kidney and Boari-modified bladder-calyceal anastomosis with bladder augmentation. Int J Urol 2007; 14:552-4. [PMID: 17593103 DOI: 10.1111/j.1442-2042.2006.01703.x] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
Abstract
A pelvic cake kidney with hydronephrosis and renal failure with the single draining ureter was reported. Frequent urination related to compression of the bladder was the most important symptom. The kidney was craniolaterally displaced, the malfunctioning ureter was replaced with the Boari-like tubularization of the bladder, and the neoureter was anastomosed with the calyx. The bladder was enlarged by intestinal augmentation.
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Affiliation(s)
- Ivan Ignjatovic
- Clinic of Urology, Faculty of Medicine, Clinical Center Nis, Nis, Serbia and Montenegro
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Türkvatan A, Demir D, Olçer T, Cumhur T. Cake kidney: MDCT urography for diagnosis. Clin Imaging 2007; 30:420-2. [PMID: 17101413 DOI: 10.1016/j.clinimag.2006.05.028] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/16/2006] [Accepted: 05/10/2006] [Indexed: 10/23/2022]
Abstract
Cake (fused pelvic) kidney is an uncommon congenital anomaly. Early diagnosis and recognition of potential complications that may accompany this anomaly are important to prevent permanent renal impairment. To the best of our knowledge, this is the first report on a case of cake kidney that was diagnosed by multidetector row computed tomographic urography.
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Affiliation(s)
- Aysel Türkvatan
- Department of Radiology, Türkiye Yüksek Ihtisas Hospital, 06100 Sihhiye, Ankara, Turkey.
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Janoff D, Hazard J, Parra RO. Renal cell carcinoma in cross renal ectopia with fusion: diagnosis and operative planning by multidetector three-dimensional computed tomography. Urology 2004; 64:152-3. [PMID: 15245955 DOI: 10.1016/j.urology.2004.02.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/03/2003] [Revised: 02/05/2004] [Accepted: 02/05/2004] [Indexed: 11/24/2022]
Affiliation(s)
- Daniel Janoff
- Division of Urology and Renal Transplantation, Department of Surgery, Oregon Health and Science University, Portland, Oregon 97201-3098, USA
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