• primary pulmonary meningioma
• recurrence
• surgery

• 18F-fluorodeoxyglucose
• Case report
• PET/CT
• Primary pulmonary meningioma

• Humans
• Meningioma/complications
• Meningioma/diagnostic imaging
• Meningioma/surgery
• Bronchi/diagnostic imaging
• Bronchoscopy
• Trachea
• Meningeal Neoplasms

• FDG PET
• multiple micronodules
• primary pulmonary meningioma

• clinicopathological features
• lobectomy
• papillary renal cell carcinoma
• primary pulmonary meningioma

• Male
• Humans
• Middle Aged
• Carcinoma, Renal Cell/complications
• Carcinoma, Renal Cell/diagnosis
• Carcinoma, Renal Cell/surgery
• Meningioma/diagnosis
• Meningioma/diagnostic imaging
• Lung/pathology
• Lung Neoplasms/complications
• Lung Neoplasms/diagnosis
• Lung Neoplasms/surgery
• Multiple Pulmonary Nodules/pathology
• Meningeal Neoplasms/pathology
• Kidney Neoplasms/complications
• Kidney Neoplasms/surgery
• Kidney Neoplasms/pathology

Lung cancer has become a leading cause of cancer‐related deaths. With the conventional use of low‐dose spiral computed tomography (CT) in physical examinations, an increasing number of small pulmonary nodules are screened. However, primary pulmonary meningiomas (PPMs) are rarely reported. Here, we report the case of a 64‐year‐old woman who had a CT scan during physical examination, which revealed three ground‐glass‐like opacity pulmonary nodules in both lungs. The patient underwent video‐assisted thoracoscopic wedge resection of the right upper and lower lobes. Paraffin sections revealed pulmonary meningothelial‐like and collagenous nodules in the right upper and lower lobes which stained as follows: EMA+, VIM+, SMA‐, S‐100‐, CD34‐, STAT6‐, Ki‐67+ (2%), and CgA‐. Primary pulmonary meningiomas (PPMs) were finally diagnosed. PPM is a kind of rare and benign tumor. Surgery can provide a precise pathological examination, and patients can achieve an excellent prognosis after surgical resection.

Primary pulmonary meningioma (PPM) is a rare disease that is usually benign. The most common presentation of PPM is isolated pulmonary nodules or masses, so the disease can mimic any other lung tumor on imaging, especially lung cancer or metastasis.

A 47-year-old asymptomatic woman presented with a well-defined, lobulated pulmonary mass with calcification in the left lower lobe. The mass measured 69 mm × 57 mm × 61 mm and was found during a chest computed tomography (CT) performed for physical examination. Contrast-enhanced CT and positron emission tomography (PET)/CT revealed mild enhancement of the mass, with accumulation of 18-fluoro-2-deoxy-D-glucose (¹⁸F-FDG). Transbronchial biopsy suggested a provisional diagnosis of low-grade neuroendocrine tumor. Subsequent enhanced head magnetic resonance imaging revealed no positive lesions. An open cuff resection of the left lower lobe and wedge resection of the lingual segment were performed. Histopathological and immunohistochemical examination revealed that the mass was a PPM.

PPM should be considered in the differential diagnosis of isolated pulmonary masses found incidentally on CT and should be diagnosed based on a combination of radiological and histological features. Surgical resection is currently the main treatment strategy. No recurrence of benign PPMs has been reported after complete resection.

• Primary pulmonary meningioma
• Contrast-enhanced computed tomography
• Positron emission tomography
• Case report

• 18F-fluorodeoxyglucose
• Metastasis
• PET/CT
• Primary pulmonary meningioma
• Rectal carcinoma

• hepatic metastases
• chemotherapeutic agents
• chemotherapy
• malignant meningiomas
• metastatic meningioma

• Craniotomy
• Hepatectomy
• Humans
• Liver
• Meningeal Neoplasms/surgery
• Meningioma/surgery

• Pathological diagnosis
• Primary
• Pulmonary meningioma

Lung cancer screening with computed tomography (CT) has been adopted worldwide. Consequently, there is an increase of some previously rarely reported lesions, like pleuropulmonary meningothelial proliferation (PMP), which included metastatic pulmonary meningiomas (MPMs), primary pulmonary meningiomas (PPMs) and minute pulmonary meningothelial-like nodules (MPMNs). To date, the understanding of the clinical management of PMP is limited.

We retrospectively searched PMP (MPMs, PPMs, and MPMNs) on the medical database (May 2005 to April 2019) of our department, and extracted the demographic and perioperative information. The last follow-up was in May 2019.

A total of 78 patients, including 16 (20.5%) males and 62 (79.5%) females, were enrolled, with the median age as 61 (range, 27–78) years. There was 1 case with multiple MPMs, 4 cases with PPMs and 73 cases with MPMNs. On CT, MPMs manifested as round nodules with solid or part-solid components. PPM mainly presented as an isolated, round, solid, and well-circumscribed nodule, with or without lobulation. While MPMNs often showed as multiple, round, randomly-distributed, solid or partly-solid nodules, most of which were in tiny size. Histologically, MPM, PPM, and MPMN had similar morphological and immunohistochemical (IHC) features. As to the surgical outcomes, the case with multiple MPMs had undergone a progression after wedge resection and was in an active monitoring. And the four cases with PPMs and the five cases with MPMNs were all in regular surveillance.

PPM has variable radiological manifestations. But it can be histologically identified by the characteristic features. Although surgery is able to achieve satisfying prognosis, active observation is an alternative in selected cases due to the surgical invasiveness and the indolent nature of the disease.

• Pulmonary meningothelial proliferation
• histology
• radiology
• surgery

Ectopic meningioma is a generally rare type of benign tumor that very rarely occurs in the lung. Here, we report the cytological findings of a primary pulmonary meningioma with a particular focus on immunohistochemical (IHC) assessment. A healthy 60‐year‐old woman visited our hospital with an asymptomatic nodule in the right lower lung lobe. She had no particular past‐history and no other tumors in the central nervous system or elsewhere according to an imaging examination. Transbronchial fine‐needle aspiration cytology revealed clusters of spindle cells in a whorled formation and psammoma bodies. The tumor cells exhibited spindle‐shaped cytoplasm, small fusiform or round nuclei and numerous intranuclear cytoplasmic inclusions. IHC staining of the cytological specimen revealed that the tumor cells were positive for epithelial membrane antigen, negative for thyroid transcription factor‐1 and p40, and equivocal for claudin‐1. Progesterone receptor immunoreactivity of cytology specimen resulted negative at first by manual method but retrieved positive by an autostainer. Following segmentectomy, the pathological diagnosis was a meningothelial meningioma. The patient has remained well without recurrence for 36 months postoperatively. Because the cytological preparation exhibited characteristic findings of meningioma, a correct diagnosis based on pre‐operative cytological findings with appropriate IHC would be possible. Here, we report the cytological and IHC features of this case and highlight the importance of IHC‐quality assurance.

• ectopic meningioma
• fine needle aspiration cytology
• immunohistochemistry
• lung neoplasm
• primary pulmonary meningioma
• quality assurance

Primary pulmonary meningiomas are very rare, and primary intraosseous meningiomas outside the head and neck region have not yet been reported. We report an extremely unusual case of concurrent meningiomas arising in the pulmonary parenchyma and vertebral bone.

A 40-year-old Asian woman presented with a destructive lesion of the lumbar vertebral bone and a small nodule in the right lung. Five years later, both lesions slightly increased in size. To evaluate both the pulmonary and vertebral lesions, video-assisted thoracic surgery and curettage of the lytic lesion were performed. Both lesions showed similar histopathological findings corresponding to an intracranial meningioma of World Health Organization grade 1. The patient made good postoperative progress and remained free from disease at 41 months after the operation.

Our patient presented with almost synchronous pulmonary and lumbar vertebral intraosseous meningiomas. Regarding the relationship between the two lesions, there are two possibilities: Independent tumors occurred coincidentally or the primary pulmonary meningioma metastasized to the vertebral bone despite its bland morphology. It is important to keep in mind the exceptionally rare condition of extracranial meningioma.

• Extracranial meningioma
• Lung
• Vertebral bone

Meningiomas are slow growing neoplasms of the central nervous system (CNS). Most of the tumors are benign and distant metastasis from a benign meningioma is rare. Metastasis to the liver, although rare, usually presents with hypoglycemia or occurs in conjunction with a clinical history of an intracranial meningioma or following the resection of a prior CNS meningioma, thus making clinical diagnosis relatively easy. Here we present an unusual case of metastatic meningioma to the liver in a 54-year-old female who presented with an incidental liver mass by ultrasound. Her clinical history and physical examination were unremarkable. A partial hepatectomy revealed a meningioma on histology. Further investigation by imaging studies showed a frontal parasagittal dural mass which was confirmed to be a World Health Organization (WHO) grade 1 meningioma. To our knowledge, this is the first report of a clinically silent metastatic meningioma to the liver without either a concurrent or a previous history of meningioma. Precise diagnosis of this challenging case requires high clinical suspicion, histopathology, and immunohistochemistry.

• computed tomography
• lung
• primary pulmonary meningioma

• Diagnosis, Differential
• Humans
• Lung/diagnostic imaging
• Lung/pathology
• Lung/surgery
• Lung Neoplasms/diagnostic imaging
• Lung Neoplasms/pathology
• Lung Neoplasms/surgery
• Male
• Meningeal Neoplasms/diagnostic imaging
• Meningeal Neoplasms/pathology
• Meningeal Neoplasms/surgery
• Meningioma/diagnostic imaging
• Meningioma/pathology
• Meningioma/surgery
• Middle Aged
• Tomography, X-Ray Computed

• Choristoma/pathology
• Female
• Humans
• Lung Diseases/pathology
• Lung Neoplasms/diagnosis
• Lung Neoplasms/pathology
• Meninges
• Meningioma/diagnosis
• Meningioma/pathology
• Middle Aged
• Organ Specificity
• Solitary Pulmonary Nodule/pathology

• Benign
• Case report
• Multiple
• Primary pulmonary meningioma

Primary pulmonary meningiomas represent a rare tumor entity. Few cases have been reported in the English medical literature, and they have almost all been solitary and benign in nature, with the exception of several extremely rare cases. We report herein a case of PPM that raised suspicion of a pulmonary metastatic tumor initially, as it was depicted as a single, round, small, ground-glass opacity pulmonary nodule on a chest computed tomography scan, in a 55-year-old man with a history of buccal cancer. Increased awareness of the clinical and radiologic characteristics of this rare category can assist a multidisciplinary team to perform adequate management.

• Computed tomography
• Lung
• Meningioma
• Solitary pulmonary nodule