Comparison of standard vs auxiliary (contrast or elastography) endoscopic ultrasound-guided fine needle aspiration/biopsy in solid pancreatic lesions: A meta-analysis

Figure 1 PRISMA flowchart for study identification, selection, and inclusion process.

Figure 2 Risk of bias assessment using QUADAS-2 tool. A: Methodological quality for individual studies; B: Methodological quality summary graph.

Figure 3 Sensitivity and specificity for diagnosis of malignancy from pancreatic solid lesion with endoscopic ultrasound-guided fine needle aspiration/biopsy using. A and C: Standard; B: Auxiliary technique. The summary receiver operating characteristic curves for sensitivity and specificity of endoscopic ultrasound-guided fine needle aspiration/biopsy using; D: Auxiliary technique with their 95%CI and 95% prediction interval.

Figure 4 Fagan plot for endoscopic ultrasound-guided fine needle aspiration/biopsy using. A and B: Standard; C: Auxiliary technique. Deeks’ plot for endoscopic ultrasound-guided fine needle aspiration/biopsy using; D: Auxiliary technique.

Figure 5 Relative sensitivity and specificity of endoscopic ultrasound-guided fine needle aspiration/biopsy using auxiliary technique, compared to standard technique.

Figure 6 Forest plot for comparison of diagnostic accuracy between endoscopic ultrasound-guided fine needle aspiration/biopsy using auxiliary technique and standard technique. A: All studies; B: Studies reporting data after the first pass.