Rath MM, Anirvan P, Varghese J, Tripathy TP, Patel RK, Panigrahi MK, Giri S. Comparison of standard vs auxiliary (contrast or elastography) endoscopic ultrasound-guided fine needle aspiration/biopsy in solid pancreatic lesions: A meta-analysis. World J Methodol 2025; 15(3): 97415 [DOI: 10.5662/wjm.v15.i3.97415]
Corresponding Author of This Article
Suprabhat Giri, DM, Assistant Professor, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Kushabhadra Campus, 5 KIIT Rd, Patia, Bhubaneswar 751024, Odisha, India. supg19167@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Methodol. Sep 20, 2025; 15(3): 97415 Published online Sep 20, 2025. doi: 10.5662/wjm.v15.i3.97415
Comparison of standard vs auxiliary (contrast or elastography) endoscopic ultrasound-guided fine needle aspiration/biopsy in solid pancreatic lesions: A meta-analysis
Mitali Madhumita Rath, Department of Pathology, IMS and SUM Hospital Campus-2, Bhubaneshwar 754001, Odisha, India
Prajna Anirvan, Department of Gastroenterology, Kalinga Gastroenterology Foundation, Cuttack 753001, Odisha, India
Jijo Varghese, Department of Gastroenterology, NS Memorial Institute of Medical Sciences, Kollam 691020, Kerala, India
Tara Prasad Tripathy, Ranjan K Patel, Department of Radiodiagnosis, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India
Manas Kumar Panigrahi, Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India
Suprabhat Giri, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar 751024, Odisha, India
Co-first authors: Mitali Madhumita Rath and Prajna Anirvan.
Author contributions: Panigrahi MK and Giri S contributed to the conception and design of the manuscript; Rath MM, Anirvan P, Varghese J, Tripathy TP, Patel RK, and Giri S contributed to the literature review, analysis, data collection, and interpretation; Rath MM, Anirvan P, and Giri S drafted the initial manuscript; Rath MM, Panigrahi MK and Giri S contributed to the critical revision of the initial manuscript; All the authors approved the final version of the manuscript.
Conflict-of-interest statement: All the authors declare no conflict of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2021 Checklist, and the manuscript was prepared and revised according to the PRISMA 2021 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Suprabhat Giri, DM, Assistant Professor, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Kushabhadra Campus, 5 KIIT Rd, Patia, Bhubaneswar 751024, Odisha, India. supg19167@gmail.com
Received: May 29, 2024 Revised: November 3, 2024 Accepted: December 2, 2024 Published online: September 20, 2025 Processing time: 280 Days and 17.6 Hours
Core Tip
Core Tip: Auxiliary techniques like elastography and contrast enhancement are being used during endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) to guide tissue acquisition from viable tumor tissue and improve diagnostic outcomes. However, the present meta-analysis reported comparable sensitivity, specificity, and diagnostic accuracy between EUS-FNA/B with and without auxiliary techniques. Subgroup analysis of studies exclusively using contrast-enhanced harmonic-EUS-FNA/B, randomized studies, and studies reporting diagnostic outcomes after the first pass reported no difference between both modalities. Thus, using EUS-FNA/B with auxiliary techniques for pancreatic solid lesions does not provide any additional advantage over standard EUS-FNA/B.
