Birtane M, Yavuz S, Taştekin N. Laboratory evaluation in rheumatic diseases. World J Methodol 2017; 7(1): 1-8 [PMID: 28396844 DOI: 10.5662/wjm.v7.i1.1]
Corresponding Author of This Article
Selçuk Yavuz, MD, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Trakya University, Balkan Campus, Edirne 22040, Turkey. selcukyavuz@trakya.edu.tr
Research Domain of This Article
Rheumatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Methodol. Mar 26, 2017; 7(1): 1-8 Published online Mar 26, 2017. doi: 10.5662/wjm.v7.i1.1
Laboratory evaluation in rheumatic diseases
Murat Birtane, Selçuk Yavuz, Nurettin Taştekin
Murat Birtane, Selçuk Yavuz, Nurettin Taştekin, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Trakya University, Edirne 22040, Turkey
Author contributions: All authors equally contributed to this paper with literature review, drafting, critical revision, editing, and final approval of the final version.
Conflict-of-interest statement: All authors declare no potential conflicts of interests for this paper and no financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Selçuk Yavuz, MD, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Trakya University, Balkan Campus, Edirne 22040, Turkey. selcukyavuz@trakya.edu.tr
Telephone: +90-505-4876184 Fax: +90-284-2357641
Received: August 26, 2016 Peer-review started: August 26, 2016 First decision: November 29, 2016 Revised: January 6, 2017 Accepted: January 16, 2017 Article in press: January 18, 2017 Published online: March 26, 2017 Processing time: 210 Days and 8.1 Hours
Core Tip
Core tip: Serological and proteomic biomarkers are useful in confirming clinically suspected preliminary diagnosis, monitoring the treatment response and prognosis of autoimmune diseases. Tests for acute phase proteins, rheumatoid factor, anti-citrullinated peptide antibodies and antinuclear antibodies, may support the diagnoses of rheumatic diseases. But these biomarkers should be used beside a careful anamnesis and detailed physical examination. Improper using of these tests may cause false-positive results and unnecessary harmful treatments. The sensitivity, specificity and likelihood ratios of the test must be known. If the test is highly specific, the diagnosis can be confirmed in case of positivity and if it is highly sensitive, the possible diagnosis can be excluded in case of negativity.
